Bupropion Hydrochloride versus Placebo, in Combination with Cognitive Behavioral Therapy, for the Treatment of Cocaine Abuse/Dependence
Abstract
Bupropion hydrochloride is a dopamine and norepinephrine reuptake inhibitor which may be an effective treatment for cocaine dependence due to its ability to reverse deficits in dopaminergic functioning that occur in chronic cocaine users. We performed a randomized, double-blind, placebo controlled trial comparing outpatient treatment with bupropion (N = 37) and placebo (N = 33) in combination with standard cognitive behavioral therapy. There were no statistically significant differences between bupropion and placebo in treatment outcomes, including aggregate measures of urine drug screen results (Joint Probability Index at 16 weeks: 0.43 for bupropion and 0.38 for placebo), treatment retention, cocaine craving ratings, and assessments of depressive symptoms. The failure to find an effect for bupropion relative to placebo, when combined with standard cognitive behavioral therapy, dampens enthusiasm for future development of bupropion as a cocaine pharmacotherapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Research has demonstrated that patients with StUD who have not achieved initial treatment goals may benefit from extended treatment with EBIs to facilitate long-term recovery.
“Research has demonstrated that patients with StUD who have not achieved their treatment goals during the initial phase of treatment may benefit from extended treatment with EBIs to facilitate long-term recovery.95,99,103,104”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [103]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 39 · Cited by 54
- Authors
- Shoptaw, S., Heinzerling, K. G., Rotheram-Fuller, E., Kao, U. H., Wang, P.-C., Bholat, M. A., & Ling, W.
- Affiliations
- a UCLA, Department of Family Medicine , Los Angeles, CA, USA
- University of California, Los Angeles (US)
- Venue
- Journal of Addictive Diseases
- Publisher
- Informa UK Limited
- Published
- 2008-02-27
- Volume
- 27
- Issue
- 1
- Pages
- 13-23
- ISSN
- 1055-0887 (ISSN-L)
- 1545-0848
- OpenAlex
- W2158252144
- Cited by
- 54
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Addictive Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (P50 DA-12755, P50DA012755)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- bupropion hydrochloride, cocaine dependence, cocaine abuse, cognitive behavioral therapy, pharmacotherapy, cocaine craving, depressive symptoms, treatment retention, urine drug testing, outpatient care
- MeSH terms
- Adult, Combined Modality Therapy, Counseling, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Cognitive Behavioral Therapy, Bupropion, Antidepressive Agents, Second-Generation, Cocaine-Related Disorders, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
