Cited by 1,180Fibromyalgia and Chronic Fatigue Syndrome ResearchLong-Term Effects of COVID-19Infectious Encephalopathies and Encephalitis

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols

Carruthers, Bruce M., Jain, Anil Kumar, De Meirleir, Kenny L., Peterson, Daniel L., Klimas, Nancy G., Lerner, A. Martin, Bested, Alison C., Flor-Henry, Pierre, Joshi, Pradip, Powles, A. C. Peter, Sherkey, Jeffrey A., van de Sande, Marjorie I.·2003·Journal of Chronic Fatigue Syndrome

DOI 10.1300/j092v11n01_02

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Abstract

Recent years have brought growing recognition of the need for clinical criteria for myalgic encephalomyelitis (ME), which is also called chronic fatigue syndrome (CFS). An Expert Subcommittee of Health Canada established the Terms of Reference, and selected an Expert Medical Consensus Panel representing treating physicians, teaching faculty and researchers. A Consensus Workshop was held on March 30 to April 1,2001 to culminate the review process and establish consensus for a clinical working case definition, diagnostic protocols and treatment protocols. We present a systematic clinical working case definition that encourages a diagnosis based on characteristic patterns of symptom clusters, which reflect specific areas of pathogenesis. Diagnostic and treatment protocols, and a short overview of research are given to facilitate a comprehensive and integrated approach to this illness. Throughout this paper, “myalgic encephalomyelitis” and “chronic fatigue syndrome” are used interchangeably and this illness is referred to as “ME/CFS.”

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The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., & and International Chronic Fatigue Syndrome Study Group. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00009 · Cited by 4,969
Being There: Putting Brain, Body, and World Together Again
Clark, A. (1996) · The MIT Press eBooks · doi:10.7551/mitpress/1552.001.0001 · Cited by 4,470
Untitled work
(2005) · Medical Entomology and Zoology · Cited by 3,197
Being There: Putting Brain, Body and World Together Again.
van Gelder, T., & Clark, A. (1998) · The Philosophical Review · doi:10.2307/2998391 · Cited by 3,134
Myofascial pain and dysfunction : the trigger point manual
Travell, J. G., & Simons, D. G. (1982) · Medical Entomology and Zoology · Cited by 2,735
The use of the nitrogen mustards in the palliative treatment of carcinoma.With particular reference to bronchogenic carcinoma
Karnofsky, D. A., Abelmann, W. H., Craver, L. F., & Burchenal, J. H. (1948) · Cancer · doi:10.1002/1097-0142(194811)1:4 · Cited by 2,238
Chronic Fatigue Syndrome: A Working Case Definition
Holmes, G. P., KAPLAN, J. E., GANTZ, N. M., KOMAROFF, A. L., SCHONBERGER, L. B., STRAUS, S. E., Jones, J. F., DUBOIS, R. E., CUNNINGHAM-RUNDLES, C., Pahwa, S. G., et al. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-387 · Cited by 1,713
Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis
Lindenbaum, J., Healton, E. B., Savage, D. G., Brust, J. C. M., Garrett, T. J., Podell, E. R., Margell, P. D., Stabler, S. P., & Allen, R. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806303182604 · Cited by 1,300
Functional somatic syndromes: one or many?
Wessely, S., Nimnuan, C., & Sharpe, M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)08320-2 · Cited by 1,211
A report—Chronic fatigue syndrome: Guidelines for research
Sharpe, M. C. (1991) · Journal of the Royal Society of Medicine · doi:10.1177/014107689108400224 · Cited by 1,026

Flagged first, then by citations

Show all 203 references

Research works printed but not linked: 24

Holmes GP, 1987, Is Epstein-Barr virus the cause? JAMA May, 257, 2297
Martin WJ, 1997, Pathobiol, 65, 15
Bell DS, 1995, Addison-Wesley Pub-lishing Co, Pg. 45
Dowsett EG, 1997, J CFS, 3, 29
Scott LV, 1999, Funct Neurol, 14, 3
Jason LA, 2001, Med & Psychia, 4, 29
Wessely S, 1997, The prevalence and mor-bidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care cen-ter. Am J of Pub Health, 87, 1449
Sue DY, 1999, Chest, 99, 931
Cooper RK, 1991, Houghton Mifflin Co. Boston, 59
Romano TJ, 1995, WV Med J, 91, 147
Cawthorne TE, 1945, Proceed Roy Soc of Med, 31, 270
Cooksey FS, 1945, Proceed Roy Soc of Med, 31, 273
Ridsdale L, 2001, Br J Gener Pract, Jan, 51, 19
Jacobson JI, 2001, Gazzeta Medica Italiana-Archivio Per Le Scienze Mediche, 160, 1
Cochran JW, 2001, J CFS, 8, 65
Pall ML, 2001, J CFS, 8, 39
Strayer DR, 1995, J CFS, 1, 35
Mena I, 1992, Chronic Fatigue Syndrome and the Brain, Bel Air CA, Apr, 25
Moldofsky H, 1993, Ciba Foundation Symp, 173, 262
Streeten DHP, 1998, J CFS, 4, 3
Simpson LO, 1989, N Z Med J, 102, 126
Brunet IL, 2001, Delayed-type hyper-sensitivity and chronic fatigue syndrome; the usefulness assessing T-cell activation by flow cytometry. Allerg Immunol (Paris), 33, 166
Nicolson GL, 1999, Med Sentinel, 4, 172
Nicolson GL, 1998, Biomed Ther, 16, 266

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Masquelier, É. (2008) · DIAL (Catholic University of Leuven) · Cited by 13
The importance of a research case definition
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Lange, G. (2010) · Springer eBooks · doi:10.1007/978-0-387-79948-3_544 · Cited by 13
Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS)
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Boesl, F., Goereci, Y., Schweitzer, F., Finke, C., Schild, A., Bittner, S., Steffen, F., Schröder, M., Quitschau, A., Heine, J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-55881-1 · Cited by 14
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Nam, D. (2020) · 대한한의학회지 · doi:10.13048/jkm.20007 · Cited by 12
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Abbot, N. C., & Spence, V. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68688-1 · Cited by 12
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Giménez-Orenga, K., Martín‐Martínez, E., Nathanson, L., & Oltra, E. (2025) · eLife · doi:10.7554/elife.104441.3 · Cited by 12
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Grue, J. (2013) · Critical Discourse Studies · doi:10.1080/17405904.2013.829114 · Cited by 11
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Pipper, C., Bliem, L., León, L. E., Mennickent, D., Bodner, C., Guzmán‐Gutiérrez, E., Stingl, M., Untersmayr, E., Wagner, B., Bertinat, R., et al. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02334-1 · Cited by 11
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Fehrer, A., Sotzny, F., Hoheisel, F., Stein, E., Kim, L., Kedor, C., Freitag, H., Heindrich, C., Bauer, S., Rust, R., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041086 · Cited by 11
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Asprusten, T. T., Sletner, L., & Wyller, V. B. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02713-9 · Cited by 11
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Weigel, B., Eaton-Fitch, N., Passmore, R., Cabanas, H., Staines, D., & Marshall‐Gradisnik, S. (2021) · Food & Nutrition Research · doi:10.29219/fnr.v65.5730 · Cited by 11
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Yang, M., Keller, S., & Lin, J.-M. S. (2022) · Quality of Life Research · doi:10.1007/s11136-022-03199-8 · Cited by 11

Authors: Carruthers, B. M., Jain, A. K., De Meirleir, K. L., Peterson, D. L., Klimas, N. G., Lerner, A. M., Bested, A. C., Flor-Henry, P., Joshi, P., Powles, A. C. P., Sherkey, J. A., & van de Sande, M. I.
Affiliations: Ottawa Hospital (CA)
University of Miami (US)
Wayne State University (US)
Sunnybrook Health Science Centre (CA)
University of Alberta (CA)
Memorial University of Newfoundland (CA)
McMaster University (CA)
University Health Network (CA)
Corresponding author: Carruthers, Bruce M.
ORCID: Jain, Anil Kumar
Klimas, Nancy G.
Venue: Journal of Chronic Fatigue Syndrome
Publisher: Informa UK Limited
Published: 2003-01
Volume: 11
Issue: 1
Pages: 7-115
ISSN: 1057-3321 (ISSN-L)
1547-0660
DOI: 10.1300/j092v11n01_02
OpenAlex: W2008087869
Cited by: 1,180
References: 203
Citations by year: 2026: 69 · 2025: 109 · 2024: 105 · 2023: 104 · 2022: 88 · 2021: 94 · 2020: 81 · 2019: 69 · 2018: 52 · 2017: 57 · 2016: 46 · 2015: 70 · 2014: 36 · 2013: 37 · 2012: 23
FWCI: 6.55
Type: journal article
Language: en
Open access: closed
Locations: Journal of Chronic Fatigue Syndrome (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords: chronic fatigue syndrome, clinical case definition, diagnostic criteria, symptom clusters, pathogenesis, treatment protocols, consensus panel, Health Canada

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols

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