The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Growth factors improve muscle healing in vivo
Open accessAbstract
Injury to muscles is very common. We have previously observed that basic fibroblast growth factor (b-FGF), insulin growth factor type 1 (IGF-1) and nerve growth factor (NGF) are potent stimulators of the proliferation and fusion of myoblasts in vitro. We therefore injected these growth factors into mice with lacerations of the gastrocnemius muscle. The muscle regeneration was evaluated at one week by histological staining and quantitative histology. Muscle healing was assessed histologically and the contractile properties were measured one month after injury. Our findings showed that b-FGF, IGF and to a less extent NGF enhanced muscle regeneration in vivo compared with control muscle. At one month, muscles treated with IGF-1 and b-FGF showed improved healing and significantly increased fast-twitch and tetanus strengths. Our results suggest that b-FGF and IGF-1 stimulated muscle healing and may have a considerable effect on the treatment of muscle injuries.
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Woolf, C. J. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0040 · Cited by 218
Cited by
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Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Muscle Injuries: Biology and Treatment
Järvinen, T. A. H., Järvinen, T. L. N., Kääriäinen, M., Kalimo, H., & Järvinen, M. (2005) · The American Journal of Sports Medicine · doi:10.1177/0363546505274714 · Cited by 1,072
MUSCLE INJURIES AND REPAIR: CURRENT TRENDS IN RESEARCH
HUARD, J., LI, Y., & FU, F. H. (2002) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200205000-00022 · Cited by 522
Self-citationCastillo, T. N., Pouliot, M. A., Kim, H. J., & Dragoo, J. L. (2011) · The American Journal of Sports Medicine · doi:10.1177/0363546510387517 · Cited by 498
Ljungqvist, A., Jenoure, P., Engebretsen, L., Alonso, J. M., Bahr, R., Clough, A., De Bondt, G., Dvorak, J., Maloley, R., Matheson, G., et al. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.064394 · Cited by 431
Metadata
- Authors
- Menetrey, J., Kasemkijwattana, C., Day, C. S., Bosch, P., Vogt, M., Fu, F. H., Moreland, M. S., & Huard, J.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 2000-01
- Volume
- 82-B
- Issue
- 1
- Pages
- 131-137
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2158354352
- Cited by
- 390
- References
- 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Menetrey, J., Kasemkijwattana, C., Day, C. S., Bosch, P., Vogt, M., Fu, F. H., Moreland, M. S., & Huard, J. (2000). Growth factors improve muscle healing in vivo. The Journal of Bone and Joint Surgery. British volume. https://doi.org/10.1302/0301-620x.82b1.0820131
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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