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Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators
Abstract
Herniated intervertebral disc tissue has been shown to produce a number of proinflammatory mediators and cytokines, but there have been no similar studies using discs from patients with discogenic low back pain. We have compared the levels of production of interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E 2 (PGE 2) in disc tissue from patients undergoing discectomy for sciatica (63) with that from patients undergoing fusion for discogenic low back pain (20) using an enzyme-linked immunoabsorbent assay. There was a statistically significant difference between levels of production of IL-6 and IL-8 in the sciatica and low back pain groups (p < 0.006 and p < 0.003, respectively). The high levels of proinflammatory mediator found in disc tissue from patients undergoing fusion suggest that production of proinflammatory mediators within the nucleus pulposus may be a major factor in the genesis of a painful lumbar disc.
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Citations
Cited by
Prabhu, R. M., & Patel, R. (2004) · Clinical Microbiology and Infection · doi:10.1111/j.1470-9465.2004.00843.x · Cited by 593
Lyu, F.-J., Cui, H., Pan, H., MC Cheung, K., Cao, X., Iatridis, J. C., & Zheng, Z. (2021) · Bone Research · doi:10.1038/s41413-020-00125-x · Cited by 474
A hypothesis of chronic back pain: ligament subfailure injuries lead to muscle control dysfunction
Panjabi, M. M. (2006) · European Spine Journal · doi:10.1007/s00586-005-0925-3 · Cited by 423
The pathophysiology of disc degeneration: A CRITICAL REVIEW
Hadjipavlou, A. G., Tzermiadianos, M. N., Bogduk, N., & Zindrick, M. R. (2008) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.90b10.20910 · Cited by 365
Watkins, L. R., Hutchinson, M. R., Milligan, E. D., & Maier, S. F. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.006 · Cited by 185
Metadata
- Authors
- Burke, J. G., Watson, R. W. G., McCormack, D., Dowling, F. E., Walsh, M. G., & Fitzpatrick, J. M.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 2002-03
- Volume
- 84-B
- Issue
- 2
- Pages
- 196-201
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2280235071
- Cited by
- 705
- References
- 0
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burke, J. G., Watson, R. W. G., McCormack, D., Dowling, F. E., Walsh, M. G., & Fitzpatrick, J. M. (2002). Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. The Journal of Bone and Joint Surgery. British volume. https://doi.org/10.1302/0301-620x.84b2.0840196
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