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Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads
Abstract
Multipotential processed lipoaspirate (PLA) cells extracted from five human infrapatellar fat pads and embedded into fibrin glue nodules, were induced into the chondrogenic phenotype using chondrogenic media. The remaining cells were placed in osteogenic media and were transfected with an adenovirus carrying the cDNA for bone morphogenetic protein-2 (BMP-2). We evaluated the tissue-engineered cartilage and bone using in vitro techniques and by placing cells into the hind legs of five severe combined immunodeficient mice. After six weeks, radiological and histological analysis indicated that the PLA cells induced into the chondrogenic phenotype had the histological appearance of hyaline cartilage. Cells transfected with the BMP-2 gene media produced abundant bone, which was beginning to establish a marrow cavity. Tissue-engineered cartilage and bone from infrapatellar fat pads may prove to be useful for the treatment of osteochondral defects.
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Citations
Cited by
Fibrin: A versatile scaffold for tissue engineering applications
Ahmed, T. A. E., Dare, E. V., & Hincke, M. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2007.0435 · Cited by 994
Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis
Koh, Y.-G., & Choi, Y.-J. (2012) · The Knee · doi:10.1016/j.knee.2012.04.001 · Cited by 392
Thompson, E. M., Matsiko, A., Farrell, E., Kelly, D. J., & O'Brien, F. J. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1918 · Cited by 147
Metadata
- Authors
- Dragoo, J. L., Samimi, B., Zhu, M., Hame, S. L., Thomas, B. J., Lieberman, J. R., Hedrick, M. H., & Benhaim, P.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 2003-07
- Volume
- 85-B
- Issue
- 5
- Pages
- 740-747
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2101471690
- Cited by
- 303
- References
- 0
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dragoo, J. L., Samimi, B., Zhu, M., Hame, S. L., Thomas, B. J., Lieberman, J. R., Hedrick, M. H., & Benhaim, P. (2003). Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads. The Journal of Bone and Joint Surgery. British volume. https://doi.org/10.1302/0301-620x.85b5.13587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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