The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Paraffin-Section Detection of CD10 in 505 Nonhematopoietic Neoplasms
Abstract
We tested 505 cases of nonhematopoietic neoplasms by immunohistochemistry using a newly characterized monoclonal antibody (clone 56C6) against the CD10 antigen. CD10 was expressed widely in neoplasms of the genitourinary tract, including 41 (89%) of 46 cases of renal cell carcinoma, 13 (54%) of 24 cases of transitional cell carcinoma, and 11 (61%) of 18 cases of prostatic adenocarcinoma. In addition, 5 (100%) of 5 endometrial stromal sarcomas, 3 (60%) of 5 rhabdomyosarcomas, 7 (50%) of 14 pancreatic adenocarcinomas, 5 (45%) of 11 cases of schwannoma, and 12 (40%) of 30 cases of malignant melanoma also were positive for CD10. Similar to normal tissue, CD10 positivity was restricted to the apical surface of malignant glandular cells of well-differentiated colonic, pancreatic, and prostatic adenocarcinoma, whereas in poorly differentiated adenocarcinoma and other tumors, such as melanoma, transitional cell carcinoma, renal cell carcinoma, and endometrial stromal sarcoma, the CD10 positivity showed diffuse cytoplasmic or membranous/Golgi patterns. The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval. CD10 expression in renal cell carcinoma and endometrial stromal sarcoma may be a useful marker in the differential diagnoses of these tumors because both tumors otherwise lack specific markers.
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Cites
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Cited by
Amin, M. B., Epstein, J. I., Ulbright, T. M., Humphrey, P. A., Egevad, L., Montironi, R., Grignon, D., Trpkov, K., Lopez-Beltran, A., Zhou, M., et al. (2014) · American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000254 · Cited by 314
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Chu, P. G., Arber, D. A., Weiss, L. M., & Chang, K. L. (2001) · Modern Pathology · doi:10.1038/modpathol.3880335 · Cited by 271
Self-citationJAZF1/JJAZ1 Gene Fusion in Endometrial Stromal Sarcomas
Hrzenjak, A., Moinfar, F., Tavassoli, F. A., Strohmeier, B., Kremser, M.-L., Zatloukal, K., & Denk, H. (2005) · The Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60568-5 · Cited by 99
Sun, H., Fukuda, S., Hirata, T., Arakawa, T., Ma, S., Neriishi, K., Wang, Y., Takeuchi, A., Saeki, A., Harada, M., et al. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00189-4 · Cited by 19
Metadata
- Authors
- Chu, P., & Arber, D. A.
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 113
- Issue
- 3
- Pages
- 374-382
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W2149350357
- Cited by
- 366
- References
- 13
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
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