The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Immunoreactivity for A103, an Antibody to Melan-A (Mart-1), in Adrenocortical and Other Steroid Tumors
Abstract
The Melan-A (MART-1) gene encodes an antigen recognized by cytotoxic T cells. It has been said to be restricted in its expression to melanocytes. However, here we report the presence of immunoreactivity for A103, an antibody to Melan-A, in five adrenocortical adenomas, 16 primary and 13 metastatic adrenocortical carcinomas, four Leydig cell tumors of the testis, and three Sertoli-Leydig cell tumors of the ovary. To evaluate the potential diagnostic role of this antibody, we studied immunoreactivity for A103 in 111 carcinomas, 40 germ cell tumors, and 33 miscellaneous nonmelanocytic epithelioid tumors. All of them were negative for A103. Our findings suggest that once melanoma is excluded, A103 can aid in the recognition of steroid hormone-producing tumors and may be particularly useful in the diagnosis of adrenocortical carcinoma. The presence of immunoreactivity for A103 practically excludes any other carcinoma that may enter into the differential diagnosis of adrenocortical tumors.
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Citations
Cites
Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors
Weiss, L. M. (1984) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198403000-00001 · Cited by 920
Pathologic features of prognostic significance in adrenocortical carcinoma
Weiss, L. M., Medeiros, L. J., & Vickery, A. L. (1989) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198903000-00004 · Cited by 818
Cited by
Fassnacht, M., Dekkers, O. M., Else, T., Baudin, E., Berruti, A., de Krijger, R. R., Haak, H. R., Mihai, R., Assie, G., & Terzolo, M. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0608 · Cited by 961
Paraffin-Section Detection of CD10 in 505 Nonhematopoietic Neoplasms
Chu, P., & Arber, D. A. (2000) · American Journal of Clinical Pathology · doi:10.1309/8vav-j2fu-8cu9-ek18 · Cited by 366
Papotti, M., Duregon, E., Volante, M., & McNicol, A. M. (2014) · Endocrine Pathology · doi:10.1007/s12022-013-9291-6 · Cited by 33
Metadata
- Authors
- Busam, K. J., Iversen, K., Coplan, K. A., Old, L. J., Stockert, E., Chen, Y.-T., McGregor, D., & Jungbluth, A.
- Venue
- The American Journal of Surgical Pathology
- Published
- 1998-01
- Volume
- 22
- Issue
- 1
- Pages
- 57-63
- ISSN
- 0147-5185 (ISSN-L)
- OpenAlex
- W2044247453
- Cited by
- 238
- References
- 2
- FWCI
- 18.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunoreactivity for A103, an Antibody to Melan-A (Mart-1), in Adrenocortical and Other Steroid Tumors. https://app.cochat.ai/papers/10.1097/00000478-199801000-00007
- The paper
- Busam, K. J., Iversen, K., Coplan, K. A., Old, L. J., Stockert, E., Chen, Y.-T., McGregor, D., & Jungbluth, A. (1998). Immunoreactivity for A103, an Antibody to Melan-A (Mart-1), in Adrenocortical and Other Steroid Tumors. The American Journal of Surgical Pathology. https://doi.org/10.1097/00000478-199801000-00007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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