The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Procalcitonin as a Marker for the Detection of Bacteremia and Sepsis in the Emergency Department
Open accessAbstract
Rapid diagnosis of bloodstream infections (BSIs) in the emergency department (ED) is challenging, with turnaround times exceeding the timeline for rapid diagnosis. We studied the usefulness of procalcitonin as a marker of BSI in 367 adults admitted to our ED with symptoms of systemic infection. Serum samples obtained at the same time as blood cultures were available from 295 patients. Procalcitonin levels were compared with blood culture results and other clinical data obtained during the ED visit. Procalcitonin levels of less than 0.1 ng/mL were considered negative; all other levels were considered positive. In 16 patients, there was evidence of BSI by blood culture, and 12 (75%) of 16 patients had a procalcitonin level of more than 0.1 ng/mL. In 186 (63.1%) of 295 samples, procalcitonin values were less than 0.1 ng/mL, and all were culture negative. With a calculated threshold of 0.1475 ng/mL for procalcitonin, sensitivity and specificity for the procalcitonin assay were 75% and 79%, respectively. The positive predictive value was 17% and the negative predictive value 98% compared with blood cultures. Procalcitonin is a useful marker to rule out sepsis and systemic inflammation in the ED.
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Cites
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., & Edmond, M. B. (2004) · Clinical Infectious Diseases · doi:10.1086/421946 · Cited by 4,496
Cited by
Faix, J. D. (2013) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2013.764490 · Cited by 663
Davies, J. (2015) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2014-202807 · Cited by 135
Metadata
- Authors
- Riedel, S., Melendez, J. H., An, A. T., Rosenbaum, J. E., & Zenilman, J. M.
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02-01
- Volume
- 135
- Issue
- 2
- Pages
- 182-189
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W1978020063
- Cited by
- 183
- References
- 3
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Riedel, S., Melendez, J. H., An, A. T., Rosenbaum, J. E., & Zenilman, J. M. (2011). Procalcitonin as a Marker for the Detection of Bacteremia and Sepsis in the Emergency Department. American Journal of Clinical Pathology. https://doi.org/10.1309/ajcp1mfyinqlecv2
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