The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Biomarkers of sepsis
Open accessAbstract
Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. A hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction is present and the patient is susceptible to nosocomial infection. Biomarkers to diagnose sepsis may allow early intervention which, although primarily supportive, can reduce the risk of death. Although lactate is currently the most commonly used biomarker to identify sepsis, other biomarkers may help to enhance lactate's effectiveness; these include markers of the hyper-inflammatory phase of sepsis, such as pro-inflammatory cytokines and chemokines; proteins such as C-reactive protein and procalcitonin which are synthesized in response to infection and inflammation; and markers of neutrophil and monocyte activation. Recently, markers of the immunosuppressive phase of sepsis, such as anti-inflammatory cytokines, and alterations of the cell surface markers of monocytes and lymphocytes have been examined. Combinations of pro- and anti-inflammatory biomarkers in a multi-marker panel may help identify patients who are developing severe sepsis before organ dysfunction has advanced too far. Combined with innovative approaches to treatment that target the immunosuppressive phase, these biomarkers may help to reduce the mortality rate associated with severe sepsis which, despite advances in supportive measures, remains high.
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Bernardi, M., Moreau, R., Angeli, P., Schnabl, B., & Arroyo, V. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.004 · Cited by 632
2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
de’Angelis, N., Catena, F., Memeo, R., Coccolini, F., Martínez-Pérez, A., Romeo, O. M., De Simone, B., Di Saverio, S., Brustia, R., Rhaiem, R., et al. (2021) · World Journal of Emergency Surgery · doi:10.1186/s13017-021-00369-w · Cited by 281
Point-of-care sensors for the management of sepsis
Reddy, B., Hassan, U., Seymour, C., Angus, D. C., Isbell, T. S., White, K., Weir, W., Yeh, L., Vincent, A., & Bashir, R. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0288-9 · Cited by 142
Tu, Y., Liu, J., Kong, D., Guo, X., Li, J., Long, Z., Peng, J., Wang, Z., Wu, H., Liu, P., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.014 · Cited by 89
Caicedo, A., Zambrano, K., Sanon, S., Luis Vélez, J., Montalvo, M., Jara, F., Moscoso, S. A., Vélez, P., Maldonado, A., & Velarde, G. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.02.014 · Cited by 48
Metadata
- Authors
- Faix, J. D.
- Venue
- Critical Reviews in Clinical Laboratory Sciences
- Publisher
- Informa UK Limited
- Published
- 2013-01
- Volume
- 50
- Issue
- 1
- Pages
- 23-36
- ISSN
- 1040-8363 (ISSN-L)
- 1549-781X
- OpenAlex
- W1973468590
- Cited by
- 663
- References
- 127
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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