The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Low Vitamin D Levels Correlate With the Proinflammatory State in Type 1 Diabetic Subjects With and Without Microvascular Complications
Abstract
Epidemiologic studies link vitamin D deficiency to onset of type 1 diabetes mellitus (T1DM). T1DM exhibits increased inflammation, which is pronounced with microvascular complications (T1DM-MV). However, there are a paucity of data on vitamin D in T1DM-MV in relation to biomarkers of inflammation, and this formed the aim of the study. Healthy control subjects (n = 36), patients with T1DM (n = 24), and patients with T1DM-MV (n =26) were recruited. Serum vitamin D levels, monocyte toll-like receptor (TLR) 2 and TLR4 expression and nuclear factor-κB (NFκB) activity were assessed. Patients with T1DM and T1DM-MV were significantly vitamin D deficient compared with control subjects (P < .01). There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFκB activity, and TLR4 expression (P < .05). Preincubation with vitamin D significantly decreased lipopolysaccharide-activated TLR4 expression and cytokine levels in monocytes (P < .05). Low vitamin D levels may contribute to increased inflammation in T1DM. Future studies will elucidate the immunomodulatory effects of vitamin D in decreasing vascular risk in this population.
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“I n another study, isoflavone-rich soya (107 mg/d as aglycone; 50 % as genestein) for 6 weeks did not affect sVCAM-1, sICAM-1 or sE-selectin concentrations in healthy postmenopausal women compared with isoflavone-poor soya (815) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [815]
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Rivoira, M. A., Rodríguez, V. A., Picotto, G., Battaglino, R. A., & de Talamoni, N. T. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.12.001 · Cited by 41
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“Low level of vitamin D causes inflammatory process and increases microvascular complications [20].”
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Vitamin D and toll like receptors
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“Another possibility is that diabetes mellitus is a cause for vitamin D deficiency (6, 20) as a consequence of intestine microangiopathy with insufficient absorption or kidney inability to hydroxylate 25‐ohd into 1,25(oh)2d (29).”
BackgroundFaghfouri, A. H., Zarrin, R., Maleki, V., Payahoo, L., & Khajebishak, Y. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104619 · Cited by 23
The Role of Toll‐Like Receptors and Vitamin D in Diabetes Mellitus Type 1 – A Review
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“The deficiencies in 1,25-(OH)2D3 and VDR are reported to be associated with chronic inflammatory disorders, such as obesity, cardiovascular diseases, and diabetes mellitus as well as diabetic complications [10–14].”
BackgroundThe Role of N6‐Methyladenosine in Inflammatory Diseases
Xu, H., Lin, C., Yang, J., Chen, X., Chen, Y., Chen, J., Guo, A., & Hu, C. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9744771 · Cited by 19
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“Unlike a previous report [25], blood levels of CRP did not show any significant association with 25(OH)VD or even AAT levels in healthy subjects or diabetic patients.”
ResultToth, B. E., Takács, I., Szekeres, L., Szabó, B., Bakos, B., & Lakatos, P. L. (2017) · Journal of Pharmacovigilance · doi:10.4172/2329-6887.1000233 · Cited by 12
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“About the first mechanism, lower VD levels are associated with increased inflammatory markers in DM patients [C-reactive protein (CRP), expression of 2 and 4 toll-like receptors, interleukins, and κB nuclear factor (NF-kB)] 40 .”
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“관련 있다는 사실이 밝혀졌고, 비타민 D 결핍은 세계적으로 증 가되는 양상이다[12].”
Wu, E. L., & Cui, H. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15038553 · Cited by 5
“15038553 be induced, leading to impaired organ structure and function (Devaraj et al., 2011).”
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“Nowadays, there is much evidence of decreased vitamin D levels in people affected with inflammatory disorders such as systemic autoimmune disease (rheumatoid arthritis, systemic lupus erythematosus and Type I diabetes mellitus), inflammatory bowel disease (Crohn’s disease and ulcerative colitis) and even chronic obstr…”
BackgroundAssociation between Vitamin D Deficiency and Psoriasis: A Case-Control Study
Allayali, A. Z., Niaz, G., Hawsawi, K. A. A., Fatani, M. I. A., Siddiqui, I., Baghdadi, R., Sulimani, H. A., & Alhawsawi, W. (2018) · Journal of Clinical & Experimental Dermatology Research · doi:10.4172/2155-9554.1000442 · Cited by 4
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“Aortic sclerosis may be associated with increased thrombotic risk [34] and the proinflammatory profile seen with Vitamin D deficiency may contribute to this risk [35].”
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LE DIABETE DE TYPE 1 : de la prédisposition génétique à un contexte environnemental hypothétique
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“…IL-2, IL-6, IFN-c , and TNF-a (Amini Kadijani et al., 2021; Amirkhizi et al., 2022; Barker et al., 2013a; Bellia et al., 2013; De Vita et al., 2014; Devaraj et al., 2011; Fu et al., 2021; Inanir et al., 2004; Liu et al., 2025; Riazati et al., 2025; Srikanth et al., 2016; Vayrynen et al., 2016;…”
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“Despite its traditional function in mineral metabolism, vitamin D has been linked to the control of the renin–angiotensin–aldosterone pathway, inflammatory pathways, endothelial function, and autonomic cardiovascular control [9,13,14,46–49].”
Metadata
- Authors
- Devaraj, S., Yun, J.-M., Duncan-Staley, C. R., & Jialal, I.
- Affiliations
- University of California Davis Medical Center (US)
- Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA
- Sacramento VA Medical Center (US)
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-01
- Volume
- 135
- Issue
- 3
- Pages
- 429-433
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W2036701286
- Cited by
- 69
- References
- 16
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 13
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK69801)
- National Center for Complementary and Integrative Health (K-24AT00596, K24AT000596)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- vitamin D deficiency, type 1 diabetes, diabetic microvascular complications, inflammation, TLR4, TLR2, NF-κB activity, C-reactive protein, monocytes, lipopolysaccharide, cytokines, immunomodulation
- MeSH terms
- NF-kappaB-Inducing Kinase, Adult, C-Reactive Protein, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Female, Humans, Inflammation, Male, Monocytes, Vitamin D Deficiency, Protein Serine-Threonine Kinases, Toll-Like Receptor 2, Toll-Like Receptor 4, Microvessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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