The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Zinc-Induced Copper Deficiency
Abstract
Copper deficiency is a rare cause of sideroblastic anemia and neutropenia that often is not suspected clinically. The morphologic findings in bone marrow, while not pathognomonic, are sufficiently characteristic to suggest the diagnosis, leading to further testing to establish the correct diagnosis. Excess zinc ingestion is among the causes of copper deficiency. We present 3 cases of zinc-induced copper deficiency in which the diagnosis first was suggested on the basis of bone marrow examination. The first patient was a 47-year-old man with a debilitating peripheral neuropathy that had progressed during the previous 18 months, mild anemia, and severe neutropenia. The second was a 21-year-old man receiving zinc supplementation for acrodermatitis enteropathica in whom moderate normocytic anemia and neutropenia developed. The third patient was a 42-year-old man with anemia, severe neutropenia, and a peripheral neuropathy that had progressed during 8 months. The bone marrow findings in all cases suggested copper deficiency, which was confirmed by further laboratory testing and determined to be due to zinc excess. The morphologic features, clinical manifestations, differential diagnosis, and pathogenetic mechanisms are discussed.
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Cites
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Copper deficiency masquerading as myelodysplastic syndrome
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Cited by
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Copper and Zinc, Biological Role and Significance of Copper/Zinc Imbalance
Osredkar, J. (2011) · Journal of Clinical Toxicology · doi:10.4172/2161-0495.s3-001 · Cited by 620
Nutritional Aspects of Essential Trace Elements in Oral Health and Disease: An Extensive Review
Bhattacharya, P. T., Misra, S. R., & Hussain, M. (2016) · Scientifica · doi:10.1155/2016/5464373 · Cited by 438
Mechanick, J. I., Kushner, R. F., Sugerman, H. J., Gonzalez‐Campoy, J. M., Collazo‐Clavell, M. L., Spitz, A. F., Apovian, C. M., Livingston, E. H., Brolin, R., Sarwer, D. B., et al. (2009) · Obesity · doi:10.1038/oby.2009.28 · Cited by 345
Stimulation of bone growth following zinc incorporation into biomaterials
Qiao, Y., Zhang, W., Tian, P., Meng, F., Zhu, H., Jiang, X., Liu, X., & Chu, P. K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.101 · Cited by 318
Metadata
- Authors
- Willis, M. S., Monaghan, S. A., Miller, M. L., McKenna, R. W., Perkins, W. D., Levinson, B. S., Bhushan, V., & Kroft, S. H.
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01-01
- Volume
- 123
- Issue
- 1
- Pages
- 125-131
- ISSN
- 0002-9173 (ISSN-L)
- OpenAlex
- W1969631492
- Cited by
- 258
- References
- 33
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Willis, M. S., Monaghan, S. A., Miller, M. L., McKenna, R. W., Perkins, W. D., Levinson, B. S., Bhushan, V., & Kroft, S. H. (2005). Zinc-Induced Copper Deficiency. American Journal of Clinical Pathology. https://doi.org/10.1309/v6gv-yw2q-tyd5-c5pj
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