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Anemia and Neutropenia Caused by Copper Deficiency
Abstract
Two patients with copper deficiency had extensive bowel surgery and received long-term parenteral hyperalimentation. One was neutropenic and anemic, with dimorphous erythrocytes. Marrow examination showed a predominance of early granulocytes and cytoplasmic vacuolization of erythroid and myeloid elements. Erythroid development was megaloblastoid and diminished, with increased sideroblasts. These abnormalities disappeared after oral copper therapy, reappeared when therapy was withdrawn, and again disappeared with intravenous copper therapy. The other patient, not as severely hypocupremic, was neutropenic but not anemic. Her marrow showed normoblastic erythropoiesis with cytoplasmic vacuolization of erythroid and myeloid precursors and a predominance of early granulocytes. The neutropenia was corrected with oral copper. Possible mechanisms causing the anemia and neutropenia are discussed. The duodenum seems to be a site of copper absorption. Copper supplementation is needed for patients receiving long-term parenteral hyperalimentation.
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Citations
Cites
The role of ceruloplasmin in iron metabolism.
Roeser, H. P., Lee, G. R., Nacht, S., & Cartwright, G. E. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106460 · Cited by 365
Cited by
The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens
Djoko, K. Y., Ong, C.-L. Y., Walker, M. J., & McEwan, A. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.647099 · Cited by 417
Hypocupremia induced by zinc therapy in adults
Prasad, A. S. (1978) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1978.03290200044019 · Cited by 373
Percival, S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.5.1064s · Cited by 364
Oral Zinc in Macular Degeneration
Newsome, D. A., Swartz, M., Leone, N. C., Elston, R. C., & Miller, E. (1988) · Archives of Ophthalmology · doi:10.1001/archopht.1988.01060130202026 · Cited by 349
Copper Deficiency Myelopathy (Human Swayback)
Kumar, N. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.10.1371 · Cited by 304
Metadata
- Authors
- DUNLAP, W. M., JAMES, G. W., & HUME, D. M.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1974-04-01
- Volume
- 80
- Issue
- 4
- Pages
- 470-476
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1495939708
- Cited by
- 234
- References
- 1
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- DUNLAP, W. M., JAMES, G. W., & HUME, D. M. (1974). Anemia and Neutropenia Caused by Copper Deficiency. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-80-4-470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
