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Addendum to the International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies: Quality Control Guidelines, Comments, and Recommendations for Testing in Other Autoimmune Diseases
Open accessAbstract
Antineutrophil cytoplasmic antibody (ANCA) tests are used to diagnose and monitor inflammatory activity in Wegener granulomatosis, microscopic polyangiitis and its renal-limited variant (pauci-immune crescentic glomerulonephritis), and Churg-Strauss syndrome. The International Consensus Statement on testing and reporting of ANCA states that ANCA are demonstrated most readily in these conditions by using a combination of indirect immunofluorescence (IIF) of normal peripheral blood neutrophils and enzyme-linked immunosorbent assays (ELISAs) that detect ANCA specific for proteinase 3 or myeloperoxidase. The group that produced the International Consensus Statement has developed guidelines for the corresponding quality control activities, examples of comments for various IIF patterns and ELISA results, and recommendations for ANCA testing when inflammatory bowel disease and other nonvasculitic ANCA-associated autoimmune diseases are suspected.
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Cited by
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Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
Kain, R., Exner, M., Brandes, R., Ziebermayr, R., Cunningham, D., Alderson, C. A., Davidovits, A., Raab, I., Jahn, R., Ashour, O., et al. (2008) · Nature Medicine · doi:10.1038/nm.1874 · Cited by 455
Autoantibodies in primary sclerosing cholangitis
Hov, J. R., Boberg, K. M., & Karlsen, T. H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3781 · Cited by 187
Balavoine, A.-S., Glinoer, D., Dubucquoi, S., & Wémeau, J.-L. (2015) · Thyroid® · doi:10.1089/thy.2014.0603 · Cited by 65
Metadata
- Authors
- Savige, F., Dimech, F., Fritzler, M., Goeken, M., Hagen, M., Jennette, M., McEvoy, P., Pusey, M., Pollock, W., Trevisin, M., Wiik, M., & Wong, R.
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-01
- Volume
- 120
- Issue
- 3
- Pages
- 312-318
- ISSN
- 0002-9173 (ISSN-L)
- OpenAlex
- W2087747538
- Cited by
- 160
- References
- 0
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Addendum to the International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies: Quality Control Guidelines, Comments, and Recommendations for Testing in Other Autoimmune Diseases. https://app.cochat.ai/papers/10.1309/waep-adw0-k4lp-uhfn
- The paper
- Savige, F., Dimech, F., Fritzler, M., Goeken, M., Hagen, M., Jennette, M., McEvoy, P., Pusey, M., Pollock, W., Trevisin, M., Wiik, M., & Wong, R. (2003). Addendum to the International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies: Quality Control Guidelines, Comments, and Recommendations for Testing in Other Autoimmune Diseases. American Journal of Clinical Pathology. https://doi.org/10.1309/waep-adw0-k4lp-uhfn
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
