Mood as a predictor of disability and survival in patients newly diagnosed with ALS/MND
Abstract
Objectives. To investigate whether poor psychological status predicts shorter survival, faster progress of disease and greater disability in patients with ALS/MND (amyotrophic lateral sclerosis/motor neurone disease). Design. A prospective study of mood as a predictor of 6‐month outcome in a consecutive cohort of patients with ALS/MND. Methods. A cohort of 38 consecutive patients completed mood, self‐esteem, wellbeing and disability measures at the time of diagnosis and 6 weeks later. Survival and disability were assessed at 6 months. Results. The 10 patients who died had poorer overall mood at the 6‐week interviews. Low mood early in disease also predicted greater disability at 6 months. The poor outcomes of patients with poor psychological well‐being were not due to confounding associations between mood and disease severity. Conclusions. The data confirm McDonald, Weidenfeld, Hillel, Carpenter & Walter's (1994) finding that poor psychological status predicts poor survival in ALS/MND. This study also extend their findings by (a) recruiting patients at the point of diagnosis and therefore controlling for effects due to the duration of disease, and (b) demonstrating that mood also predicts disease progression and disability. The findings are unlikely to be due to simple spurious association of the psychological status measures with recognized indices of disease or of expected survival. Explanations for the results can be considered in the context of other findings of mood predicting outcomes of life‐threatening disease and the possible value of psychological interventions may be considered.
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Poor quality of life and psychological distress are associated with negative outcomes, including shorter survival time and increased risk of suicide, in people with motor neuron disease.
“poor quality of life and psychological distress are associated with negative outcomes, including shorter survival time and increased risk of suicide. 4-6”
Shorter survival times, poorer quality of life and increased risks of suicide and mortality have been reported in those experiencing psychological distress.
“Although shorter survival times, poorer quality of life and increased risks of suicide and mortality have been reported in those experiencing psychological distress [8–12]”
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Society and the Adolescent Self-Image
Rosenberg, M. (1965) · doi:10.1515/9781400876136 · Cited by 30,126 · see citing works
The Structure of Psychological Well-Being.
Mechanic, D., & Bradburn, N. M. (1970) · American Sociological Review · doi:10.2307/2093340 · Cited by 4,925 · see citing works
EFFECT OF PSYCHOSOCIAL TREATMENT ON SURVIVAL OF PATIENTS WITH METASTATIC BREAST CANCER
Spiegel, D., Kraemer, H., Bloom, J., & Gottheil, E. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91551-1 · Cited by 2,353 · see citing works
Depression Following Myocardial Infarction
Frasure‐Smith, N. (1993) · JAMA · doi:10.1001/jama.1993.03510150053029 · Cited by 2,028 · see citing works
Measures in Health Psychology: A User's Portfolio
Johnston, M., Wright, S., & Weinman, J. A. (1995) · Cited by 1,300 · see citing works
The "disease-prone personality": A meta-analytic view of the construct.
Friedman, H. S., & Booth‐Kewley, S. (1987) · American Psychologist · doi:10.1037/0003-066x.42.6.539 · Cited by 647 · see citing works
Major Depression Before and After Myocardial Infarction
Lespérance, F., Frasure‐Smith, N., & Talajic, M. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199603000-00001 · Cited by 465 · see citing works
Moser, D. K., & Dracup, K. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199609000-00001 · Cited by 305 · see citing works
Williams, S. J. (1989) · Sociology of Health & Illness · doi:10.1111/1467-9566.ep10844491 · Cited by 229 · see citing works
Amyotrophic Lateral Sclerosis Severity Scale
Hıllel, A. D., Miller, R. M., Yorkston, K. M., McDonald, E., Norris, F. H., & Konikow, N. S. (1989) · Neuroepidemiology · doi:10.1159/000110176 · Cited by 211 · see citing works
Survival in Amyotrophic Lateral Sclerosis: The Role of Psychological Factors
McDonald, E. R. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540130027010 · Cited by 193 · see citing works
Perceived control of recovery from physical disability: Measurement and prediction
Partridge, C. J., & Johnston, M. (1989) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1989.tb00811.x · Cited by 184 · see citing works
Do psychological factors predict survival in breast cancer?
Dean, C., & Surtees, P. G. (1989) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(89)90063-9 · Cited by 144 · see citing works
Perceived control, coping and recovery from disability following stroke
Johnston, M., Morrison, V., Macwalter, R., & Partridge, C. (1999) · Psychology and Health · doi:10.1080/08870449908407322 · Cited by 117 · see citing works
Experimental manipulation of perceived control and its effect on disability
Fisher, K., & Johnstion, M. (1996) · Psychology and Health · doi:10.1080/08870449608404995 · Cited by 57 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Prognostic factors in ALS: A critical review
Chiò, A., Logroscino, G., Hardiman, O., Swingler, R., Mitchell, D., Beghi, E., Traynor, B. G., & On Behalf of the Eurals Consortium (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960802566824 · Cited by 1,172 · see citing works
Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis
D’Amico, E., Factor-Litvak, P. R., Santella, R. M., & Mitsumoto, H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.029 · Cited by 324 · see citing works
Gruzelier, J. H. (2002) · Stress · doi:10.1080/10253890290027877 · Cited by 160 · see citing works
Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions
Grollemund, V., Pradat, P., Querin, G., Delbot, F., Chat, G. L., Pradat‐Peyre, J., & Bede, P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00135 · Cited by 154 · see citing works
Epidemiology of amyotrophic lateral sclerosis: A review of literature
Couratier, P., Corcia, P., Lautrette, G., Nicol, M., Preux, P., & Marin, B. (2015) · Revue Neurologique · doi:10.1016/j.neurol.2015.11.002 · Cited by 133 · see citing works
Prevalence of depression in a 12‐month consecutive sample of patients with ALS
Wicks, P. J., Abrahams, S., Masi, D., Hejda-Forde, S., Leigh, P. N., & Goldstein, L. H. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01843.x · Cited by 117 · see citing works
Psychological health in patients with amyotrophic lateral sclerosis
Averill, A. J., Kasarskis, E. J., & Segerstrom, S. C. (2007) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701374643 · Cited by 110 · see citing works
Gruzelier, J. H., Smith, F., Nagy, A., & Henderson, D. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00136-2 · Cited by 87 · see citing works
Linse, K., Aust, E., Joos, M., & Hermann, A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00603 · Cited by 74 · see citing works
The Dynamics of Quality of Life in ALS Patients and Caregivers
Roach, A. R., Averill, A. J., Segerstrom, S. C., & Kasarskis, E. J. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9092-9 · Cited by 81 · see citing works
Longitudinal predictors of psychological distress and self-esteem in people with ALS
Goldstein, L. H., Atkins, L., Landau, S., Brown, R. G., & Leigh, P. N. (2006) · Neurology · doi:10.1212/01.wnl.0000242886.91786.47 · Cited by 75 · see citing works
Bentley, B., O’Connor, M., Kane, R. T., & Breen, L. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096888 · Cited by 64 · see citing works
Depression in ALS in a large self-reporting cohort
Thakore, N. J., & Pioro, E. P. (2016) · Neurology · doi:10.1212/wnl.0000000000002465 · Cited by 64 · see citing works
Johnston, M., Pollard, B., Morrison, V., & MacWalter, R. (2004) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm1104_1 · Cited by 58 · see citing works
Gould, R. L., Coulson, M. C., Brown, R. G., Goldstein, L. H., Al-Chalabi, A., & Howard, R. J. (2015) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2015.1062515 · Cited by 47 · see citing works
Psychological morbidity in ALS: The importance of psychological assessment beyond depression alone
Felgoise, S. H., Chakraborty, B. H., Bond, E., Rodriguez, J. L., Bremer, B. A., Walsh, S., Lai, E. C., McCluskey, L. F., & Simmons, Z. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482961003667630 · Cited by 46 · see citing works
Psychological health in patients with ALS is maintained as physical function declines
Cupp, J. A., Simmons, Z., Berg, A. S., Felgoise, S. H., Walsh, S., & Stephens, H. (2011) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2011.554555 · Cited by 43 · see citing works
Beswick, E., Park, E. Y., Wong, C., Mehta, A. R., Dakin, R. S., Chandran, S., Newton, J. L., Carson, A. J., Abrahams, S., & Pal, S. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10203-z · Cited by 43 · see citing works
van Groenestijn, A. C., van de Port, I. G. L., Schröder, C. D., Post, M. W. M., Grupstra, H. F., Kruitwagen, E. T., van der Linde, H., van Vliet, R. O., van de Weerd, M. G., van den Berg, L. H., et al. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-70 · Cited by 40 · see citing works
Pagnini, F., Manzoni, G. M., Tagliaferri, A., & Sidey-Gibbons, C. J. (2014) · Journal of Health Psychology · doi:10.1177/1359105314530453 · Cited by 39 · see citing works
Gould, R. L., McDermott, C. J., Thompson, B. J., Rawlinson, C. V., Bursnall, M., Bradburn, M., Kumar, P., Turton, E. J., White, D. A., Serfaty, M. A., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00533-6 · Cited by 38 · see citing works
Hypnosis-based psychodynamic treatment in ALS: a longitudinal study on patients and their caregivers
Kleinbub, J. R., Palmieri, A., Broggio, A., Pagnini, F., Benelli, E., Sambin, M., & Sorarú, G. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00822 · Cited by 34 · see citing works
Cipolletta, S., Gammino, G. R., & Palmieri, A. (2017) · Journal of Clinical Nursing · doi:10.1111/jocn.14003 · Cited by 31 · see citing works
Bond, L., Bowen, G., Mertens, B., Denson, K., Jordan, K., Vidakovic, B., & Mitchell, C. S. (2020) · Behavioral Sciences · doi:10.3390/bs10010033 · Cited by 27 · see citing works
Mood in chronic disease: Questioning the answers
Johnston, M. (1999) · Current Psychology · doi:10.1007/s12144-999-1017-z · Cited by 24 · see citing works
Hope and self-efficacy are associated with better satisfaction with life in people with ALS
Galin, S., Heruti, I., Barak, N., & Gotkine, M. (2018) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2018.1476546 · Cited by 22 · see citing works
Gruzelier, J. H. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)52017-1 · Cited by 22 · see citing works
Gould, R. L., Thompson, B. J., Rawlinson, C., Kumar, P., White, D., Serfaty, M. A., Graham, C. D., McCracken, L. M., Bursnall, M., Bradburn, M., et al. (2022) · BMC Neurology · doi:10.1186/s12883-022-02950-5 · Cited by 16 · see citing works
Empathy-based supportive treatment in amyotrophic lateral sclerosis: A pragmatic study
Palmieri, A., Kleinbub, J. R., Pagnini, F., Sorarù, G., & Cipolletta, S. (2021) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2020.1797623 · Cited by 18 · see citing works
The impact of active coping strategies on survival in ALS: The first pilot study
Montel, S., Albertini, L., Desnuelle, C., & Spitz, É. (2012) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2012.711835 · Cited by 18 · see citing works
Épidémiologie, spectre clinique de la SLA et diagnostics différentiels
Couratier, P., Marin, B., Lautrette, G., Nicol, M., & Preux, P. (2014) · La Presse Médicale · doi:10.1016/j.lpm.2014.02.013 · Cited by 17 · see citing works
Gruzelier, J. H., Champion, A., Fox, P., Rollin, M., McCormack, S., Catalan, P., Barton, S. E., & Henderson, D. (2002) · Contemporary Hypnosis · doi:10.1002/ch.253 · Cited by 16 · see citing works
Suicide among veterans with amyotrophic lateral sclerosis
Lund, E. M., Hostetter, T. A., Forster, J. E., Hoffmire, C. A., Stearns‐Yoder, K. A., Brenner, L. A., & Sohi, M. T. (2021) · Muscle & Nerve · doi:10.1002/mus.27181 · Cited by 14 · see citing works
Barć, K., Szacka, K., Nieporęcki, K., de Carvalho, M. A., Gromicho, M., Großkreutz, J., Petri, S., Rödiger, A., Steinbach, R., Uysal, H., et al. (2020) · Aging and Disease · doi:10.14336/ad.2019.1120 · Cited by 13 · see citing works
Purpose in life in ALS patient–caregiver dyads: A multilevel longitudinal analysis.
Garcia-Willingham, N. E., Morey, J. N., Kasarskis, E. J., & Segerstrom, S. C. (2017) · Health Psychology · doi:10.1037/hea0000507 · Cited by 12 · see citing works
Compliance with recommendations made in a multidisciplinary ALS clinic
Fullam, T., Stephens, H., Felgoise, S. H., Blessinger, J. K., Walsh, S., & Simmons, Z. (2015) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2015.1074703 · Cited by 11 · see citing works
Predictors of distress in amyotrophic lateral sclerosis: A systematic review
Fisher, P., Dodd, R., Barrow, E., Makin, S. M., & Cherry, M. G. (2019) · Cogent Psychology · doi:10.1080/23311908.2019.1608031 · Cited by 11 · see citing works
Gould, R. L., Rawlinson, C., Thompson, B., Weeks, K., Gossage-Worrall, R., Cantrill, H., Serfaty, M. A., Graham, C. D., McCracken, L. M., White, D., et al. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01354-7 · Cited by 10 · see citing works
Campbell, M. (2007) · Psychology Health & Medicine · doi:10.1080/13548500600986526 · Cited by 9 · see citing works
Kidd, L. (2007) · Stirling Online Research Repository (University of Stirling) · Cited by 9 · see citing works
Peto, V., Jenkinson, C., Fitzpatrick, R. M., & Swash, M. (2001) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820152882205 · Cited by 7 · see citing works
Dodd, R., Fisher, P., Makin, S. M., Moore, P., & Cherry, M. G. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.609068 · Cited by 7 · see citing works
Illness Cognitions in ALS: New Insights Into Clinical Management of Behavioural Symptoms
Caga, J., Devenney, E. M., Huynh, W., Zoing, M. C., Ahmed, R. M., & Kiernan, M. C. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.740693 · Cited by 3 · see citing works
Goldstein, L. H. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543579.202 · Cited by 2 · see citing works
Roach, A. R. (2010) · UKnowledge (University of Kentucky) · Cited by 1 · see citing works
Technology to support autonomy in patients with Amyotrophic Lateral Sclerosis
Masiello, P. (2022) · Journal of Advanced Health Care · doi:10.36017/jahc2202-02 · Cited by 1 · see citing works
Chiò, A. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_204 · Cited by 1 · see citing works
Goldstein, L. H. (2019)
التوافق النفسي وعلاقته بدافعية الإنجاز لدى لاعبات الکرة الطائرة جلوس
عارف, د. س. س., & محمد, م. ز. م. (2022) · Maǧallaẗ Kulliyyaẗ Al-Adāb bi Al-Wadī Al-Ǧadīd/Maǧallaẗ Kulliyyaẗ Al-Adāb bi Al-Wadī Al-Ǧadīd · doi:10.21608/mkwn.2022.231067
Technology to support autonomy in patients with Amyotrophic Lateral Sclerosis
Masiello, P. (2022) · Journal of Advanced Health Care · doi:10.36017/jahc202241167
Loss and transcendence in couples living with MND: An Interpretative Phenomenological Analysis
Hanley, B. (2012) · Edge Hill University
Gould, R. L., Rawlinson, C. V., Thompson, B., Weeks, K., Gossage-Worrall, R., Cantrill, H., Serfaty, M. A., Graham, C. D., McCracken, L. M., White, D. A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23647495
Gould, R. L., Rawlinson, C. V., Thompson, B., Weeks, K., Gossage-Worrall, R., Cantrill, H., Serfaty, M. A., Graham, C. D., McCracken, L. M., White, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23647486
Gould, R. L., Rawlinson, C. V., Thompson, B., Weeks, K., Gossage-Worrall, R., Cantrill, H., Serfaty, M. A., Graham, C. D., McCracken, L. M., White, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23647492
Gould, R. L., Rawlinson, C. V., Thompson, B., Weeks, K., Gossage-Worrall, R., Cantrill, H., Serfaty, M. A., Graham, C. D., McCracken, L. M., White, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23647489
Unravelling the tangle of motor neuron diseases : insights from neuroimaging and neurophysiology
Querin, G. (2019) · theses.fr (ABES) · doi:10.70675/30ad3e2az5051z4364z9ec1z4b8d1f952b7b
- Authors
- Johnston, M., Earll, L., Giles, M., Mcclenahan, R., Stevens, D., & Morrison, V.
- Affiliations
- University of St Andrews (GB)
- Gloucestershire Royal Hospital (GB)
- The Royal Free Hospital (GB)
- Queen Margaret University (GB)
- Corresponding author
- Johnston, Marie
- ORCID
- Johnston, Marie
- Venue
- British Journal of Health Psychology
- Publisher
- Wiley
- Published
- 1999-05
- Volume
- 4
- Issue
- 2
- Pages
- 127-136
- ISSN
- 1359-107X (ISSN-L)
- 2044-8287
- OpenAlex
- W1964934303
- Cited by
- 57
- References
- 16
- Citations by year
- 2024: 1 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Health Psychology (publishedVersion)
- Funders
- Motor Neurone Disease Association
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- amyotrophic lateral sclerosis, motor neuron disease, mood, psychological well-being, self-esteem, survival, disability, disease progression, prognostic factors, psychological intervention
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