Carotenoids in the human retina
Open accessAbstract
Conference International Symposium on Carotenoids, International Symposium on Carotenoids, CAROT, Carotenoids, 12th, Cairns, Australia, 1999-07-18–1999-07-23 Published Online: 2009-01-01 Published in Print: 1999-01-01 © 2013 Walter de Gruyter GmbH, Berlin/Boston
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Lutein and zeaxanthin act as blue light filters and are now known to quench triplet states and scavenge 1O2*.
“These act as blue light filters yet are now known to also quench triplet states and scavenge 1O2* (299).”
From Chemiexcitation: Mammalian Photochemistry in the Dark<sup>†</sup> (2023) · cites this paper as [299]
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Cites
The Biochemistry of Natural Pigments
Britton, G. (1983) · Cited by 247 · see citing works
Dreosti, I. E. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.3.452a · Cited by 116 · see citing works
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Research works printed but not linked: 26
- W. Schalch, P. Dayhaw-Barker, F. M. Barker, In Nutritional and Environmental In¯uences on the Eye (A. Taylor), ed.), pp. 215±250. CRC Press, Boca Raton (1999).
- G. Wald. Nature (London) 101, 653 (1945).
- J. J. Nussbaum, R. C. Pruett, F. C. Delori. Retina 1, 296 (1981).
- P. K. Brown, G. Wald. Nature (London) 200, 37 (1963).
- G. J. Handelman, D. M. Snodderly, N. I. Krinsky, M. D. Russett, A. J. Adler. Invest. Ophthalmol. Vis. Sci. 32, 257 (1991).
- D. M. Snodderly, G. J. Handelman, A. J. Adler. Invest. Ophthalmol. Vis. Sci. 32, 268 (1991).
- D. M. Snodderly, J. D. Auran, F. C. Delori. Invest. Ophthalmol. Vis. Sci. 25, 674 (1984).
- H. H. Schmitz, C. L. Poor, E. T. Gugger, J. W. Erdman, Jr. In Methods in Enzymology (L. Packer, ed.), vol. 214, pp. 102±116. Academic Press, San Diego (1993).
- R. A. Bone, J. T. Landrum, S. L. Tarsis. Vision Res. 25, 1531 (1985).
- R. A. Bone, J. T. Landrum, G. W. Hime, A. Cains, J. Zamor. Invest. Ophthalmol. Vis. Sci. 34, 2033 (1993).
- R. A. Bone, J. T. Landrum, L. Fernandez, S. L. Tarsis. Invest. Ophthalmol. Vis. Sci. 29, 843 (1988). Fig. 5 Macular pigment optical density versus serum concentration of lutein for 20 human subjects. Carotenoids in the human retina 2243 q1999 IUPAC, Pure Appl. Chem. 71, 2237±2244
- R. A. Bone, J. T. Landrum. In Methods in Enzymology (L. Packer, ed.), vol. 213, pp. 360±366. Academic Press, San Diego (1992).
- D. M. Snodderly, M. D. Russett, R. I. Land, N. I. Krinsky. J. Nutr. 120, 1663 (1990).
- J. T. Landrum, R. A. Bone, L. L. Moore, C. M. Gomez. In Methods in Enzymology (L. Packer, ed.), vol. 299, pp. 457±467. Academic Press, San Diego (1999).
- R. A. Bone, J. T. Landrum, L. M. Friedes, C. M. Gomez, M. D. Kilburn, E. Menendez, I. Vidal, W. Wang. Exp. Eye Res. 64, 211 (1997).
- F. Khachik, P. S. Bernstein, D. L. Garland. Invest. Ophthalmol. Vis. Sci. 38, 1802 (1997).
- R. Goralczyk, S. Buser, J. Bausch, W. Bee, U. Zu Èhlke, F. M. Barker. Invest. Ophthalmol. Vis. Sci. 38, 741 (1997).
- B. Daicker, K. Schiedt, J. J. Adnet, P. Bermond. Graefe's Arch. Clin. Exp. Ophthalmol. 225, 189 (1987).
- P. Palozza, N. I. Krinsky. In Methods in Enzymology (L. Packer, ed.), vol. 213, pp. 403±420. Academic Press, San Diego (1992).
- J. M. Seddon, U. A. Ajani, R. D. Sperduto, R. Hiller, N. Blair, T. C. Burton, M. D. Farber, E. S. Gragoudas, J. Haller, D. T. Miller, L. A. Yannuzzi, W. Willett. J. Am. Med. Assoc. 272, 1413 (1994).
- Eye Disease Case-Control Study Group (1993). Arch. Ophthalmol. 111, 104 (1993).
- B. R. Hammond, J. Curran-Celentano, S. Judd, K. Fuld, N. Krinsky, B. R. Wooten, D. M. Snodderly. Vision Res. 36, 2001 (1996).
- B. R. Hammond, K. Fuld, D. M. Snodderly. Exp. Eye Res. 62, 715 (1996).
- B. R. Hammond, B. R. Wooten, D. M. Snodderly. Vision Res. 36, 3003 (1996).
- J. T. Landrum, R. A. Bone, H. Joa, M. D. Kilburn, L. L. Moore, K. E. Sprague. Exp. Eye Res. 65, 57 (1997).
- B. R. Hammond, Jr., E. J. Johnson, R. M. Russell, N. I. Krinsky, K. Yeum, R. B. Edwards, D. M. Snodderly. Invest. Ophthalmol. Vis. Sci. 38, 1795 (1997).
Cited by
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Bioactivity and protective effects of natural carotenoids
Stahl, W., & Sies, H. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.12.006 · Cited by 898 · see citing works
“Lutein and zeaxanthin are also dominating the carotenoid pattern of the entire retina, but the concentration in the macula lutea is considerably higher than in the rest of the retina [57].”
BackgroundLutein, Zeaxanthin, and the Macular Pigment
Landrum, J. T., & Bone, R. A. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2171 · Cited by 819 · see citing works
Self-citationLutein: More than just a filter for blue light
Kijlstra, A., Tian, Y., Kelly, E. R., & Berendschot, T. T. J. M. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.03.002 · Cited by 349 · see citing works
Delcourt, C., Carrière, I., Delage, M., Barberger‐Gateau, P., & Schalch, W. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1235 · Cited by 255 · see citing works
“Macular pigment is thought to protect against retinal damage by filtering out phototoxic short-wavelength visible light and by defending rod outer segment membranes from oxidative stress.(5) In three case–control studies, subjects with high macular pigment density had a reduced risk of age-related macular degeneration.”
Fruit and Vegetable Phytochemicals
(2009) · Wiley eBooks · doi:10.1002/9780813809397 · Cited by 137 · see citing works
Green extraction methods and environmental applications of carotenoids-a review
Singh, A., Ahmad, S., & Ahmad, A. (2015) · RSC Advances · doi:10.1039/c5ra10243j · Cited by 105 · see citing works
Phytochemicals in Nutrition and Health
(2002) · CRC Press eBooks · doi:10.1201/9781420031690 · Cited by 98 · see citing works
Chemistry, Stability, and Biological Actions of Carotenoids
Yahia, E. M., & Ornelas‐Paz, J. D. J. (2009) · doi:10.1002/9780813809397.ch7 · Cited by 91 · see citing works
Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells
Frede, K., Ebert, F., Kipp, A. P., Schwerdtle, T., & Baldermann, S. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01929 · Cited by 79 · see citing works
Possible role for dietary lutein and zeaxanthin in visual development
Hammond, B. R. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00121.x · Cited by 63 · see citing works
Chemistry, Stability, and Biological Actions of Carotenoids
Yahia, E. M., Ornelas‐Paz, J. D. J., Emanuelli, T., Lopes, E. J., Zepka, L. Q., & Cervantes‐Paz, B. (2017) · doi:10.1002/9781119158042.ch15 · Cited by 54 · see citing works
Wenzel, M., Seuß‐Baum, I., & Schlich, E. H. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903488b · Cited by 47 · see citing works
Macular Carotenoids: Lutein and Zeaxanthin
Stahl, W. (2004) · KARGER eBooks · doi:10.1159/000082768 · Cited by 45 · see citing works
Use of carotenoids in feed mixtures for poultry: a review
Marounek, M., & Pebriansyah, A. (2018) · Agricultura tropica et subtropica · doi:10.1515/ats-2018-0011 · Cited by 41 · see citing works
Chemiexcitation and Its Implications for Disease
Brash, D. E., Gonçalves, L. C. P., & Bechara, E. J. H. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.004 · Cited by 36 · see citing works
Effect of dietary lutein and flax on performance, egg composition and liver status of laying hens
Leeson, S., Caston, L. J., & Namkung, H. (2007) · Canadian Journal of Animal Science · doi:10.4141/a06-043 · Cited by 35 · see citing works
Skřivan, M., Marounek, M., Englmaierová, M., & Skřivanová, E. (2016) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/65588/2016 · Cited by 32 · see citing works
“Lutein and zeaxanthin are deposited in the macular region of the retina and reduce the risk of age-related macular degeneration (Landrum et al., 1999).”
Transference of lutein during cheese making, color stability, and sensory acceptance of prato cheese
Kubo, M. T. K., Maus, D., Xavier, A. A. O., Mercadante, A. Z., & Viotto, W. H. (2013) · Food Science and Technology · doi:10.1590/s0101-20612013000500013 · Cited by 27 · see citing works
Intracellular Uptake Mechanism of Lutein in Retinal Pigment Epithelial Cells
Sato, Y., Kondo, Y., Sumi, M., Takekuma, Y., & Sugawara, M. (2013) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j33k61 · Cited by 24 · see citing works
Oxidative stability of yogurt with added lutein dye
Domingos, L. D., Xavier, A. A. O., Mercadante, A. Z., Petenate, A. J., Jorge, R. A., & Viotto, W. H. (2013) · Journal of Dairy Science · doi:10.3168/jds.2013-6971 · Cited by 24 · see citing works
Kinetics of 14C distribution after tracer dose of 14C‐lutein in an adult woman
de Moura, F. F., Ho, C. C., Getachew, G., Hickenbottom, S. J., & Clifford, A. J. (2005) · Lipids · doi:10.1007/s11745-005-1471-4 · Cited by 22 · see citing works
Chemiexcitation: Mammalian Photochemistry in the Dark<sup>†</sup>
Brash, D. E., & Goncalves, L. C. P. (2023) · Photochemistry and Photobiology · doi:10.1111/php.13781 · Cited by 16 · see citing works
Plant Stanol and Sterol Esters and Macular Pigment Optical Density
Berendschot, T. T. J. M., & Plat, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401717-7.00044-7 · Cited by 12 · see citing works
Berendschot, T. T. J. M. (2010) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-3-540-85540-8_6 · Cited by 6 · see citing works
Jensen, S. L., & Lutnæs, B. F. (2005) · Studies in natural products chemistry · doi:10.1016/s1572-5995(05)80041-9 · Cited by 5 · see citing works
Schalch, W. (2000) · Hong Kong Journal of Ophthalmology · doi:10.12809/hkjo-v4n1-136 · Cited by 4 · see citing works
“have recently refined their analyses and investigated the retinas of a total of 56 patients with AMD and 45 control patients.(63) The eyes of the control subjects were divided into quintiles of carotenoid concentration in the outer annulus, which is normally unaffected by AMD, and the number of cases of AMD in each qu…”
BackgroundIssues of Supplemental Support in Pediatric Ophthalmology
Gndoyan, I. A. (2020) · Ophthalmology in Russia · doi:10.18008/1816-5095-2020-3-309-320 · Cited by 3 · see citing works
Britton, G., Jensen, S. L., & Pfander, H. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7836-4_2 · Cited by 2 · see citing works
Berendschot, T. T. J. M. (2013) · CRC Press eBooks · doi:10.1201/b15556-3 · Cited by 1 · see citing works
Astaxanthin, ß-Cryptoxanthin, Lutein, and Zeaxanthin
Landrum, J. T., Bone, R. A., & Herrero, C. (2002) · CRC Press eBooks · doi:10.1201/9781420031690.ch12 · Cited by 1 · see citing works
Self-citationMendez, V. (2011) · doi:10.25148/etd.fi11120808
“The concentration of the macular pigment in the central retina approaches 1 mM, more than 1000 times that in human serum and liver[19].”
BackgroundMacular pigment — its role in health and disease
Boulton, M. E. (2004) · Springer eBooks · doi:10.1007/978-3-7091-7985-7_2
Risk factors for age-related macula degeneration and their relationship with macular carotenoids.
Berendschot, T. T. J. M. (2013) · Research Publications (Maastricht University)
Wu, A. R., Anderson‐Berry, A., & Hanson, C. (2017) · HAL
- Authors
- Landrum, J. T., Bone, R. A., Chen, Y., Herrero, C., Llerena, C. M., & Twarowska, E.
- Affiliations
- Florida International University (US)
- Corresponding author
- Landrum, J. T.
- Venue
- Pure and Applied Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 1999-01-01
- Volume
- 71
- Issue
- 12
- Pages
- 2237-2244
- ISSN
- 0033-4545 (ISSN-L)
- 1365-3075
- OpenAlex
- W2104163495
- Cited by
- 38
- References
- 2
- Citations by year
- 2023: 1 · 2020: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pure and Applied Chemistry (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- carotenoids, human retina, retinal carotenoids, lutein, zeaxanthin, macular pigment
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