The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
The Placebo Effect: Illness and Interpersonal Healing
Open accessAbstract
The placebo effect has been a source of fascination, irritation, and confusion within biomedicine over the past 60 years. Although scientific investigation has accelerated in the past decade, with particular attention to neurobiological mechanisms, there has been a dearth of attention to developing a general theory of the placebo effect. In this article, we attempt to address this gap. To set the stage, we review evidence relating to the reality and clinical significance of the placebo effect. Next we investigate the scope and limits of the placebo effect by examining the hypothesis that the placebo effect operates predominantly by modifying the experience and perceptions of illness symptoms, such as pain, anxiety, and fatigue, rather than by modifying the pathophysiology of disease. Based on this background, we characterize the placebo effect as a form of interpersonal healing, as distinct from spontaneous natural healing and from technological healing dependent on physiologically active pharmaceuticals or procedures. Finally, we argue that research on the placebo effect has the potential to revitalize the art of medicine.
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Citations
Cites
The Structure of Scientific Revolutions
Kuhn, T. S., & Schlegel, R. (1963) · Physics Today · doi:10.1063/1.3050879 · Cited by 35,538
The illness narratives: suffering, healing, and the human condition
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Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
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Is the Placebo Powerless?: An Analysis of Clinical Trials Comparing Placebo with No Treatment
Hróbjartsson, A., & Gøtzsche, P. C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105243442106 · Cited by 1,503
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
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Persuasion and Healing: A Comparative Study of Psychotherapy
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A meta-analysis of the association between adherence to drug therapy and mortality
Simpson, S. H., Eurich, D. T., Majumdar, S. R., Padwal, R. S., Tsuyuki, R. T., Varney, J., & Johnson, J. A. (2006) · BMJ · doi:10.1136/bmj.38875.675486.55 · Cited by 1,353 · cited 2×
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Some randomized trials have detected an association between compliance with placebo interventions in randomized trials and outcomes such as mortality (Simpson et al. 2006).”
BackgroundMaterson, B. J., Reda, D. J., Cushman, W. C., Massie, B. M., Freis, E. D., Kochar, M. S., Hamburger, R. J., Fye, C., Lakshman, R., Gottdiener, J., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304013281303 · Cited by 1,199
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., et al. (2008) · BMJ · doi:10.1136/bmj.39524.439618.25 · Cited by 1,196 · cited 1×
“A recent clinical experiment is noteworthy in attempting to identify components of the placebo effect and their impact on therapeutic outcomes (Kaptchuk et al. 2008).”
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Cited by
Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome
Kaptchuk, T. J., Friedlander, E., Kelley, J. M., Sanchez, M. N., Kokkotou, E., Singer, J. P., Kowalczykowski, M., Miller, F. G., Kirsch, I., & Lembo, A. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015591 · Cited by 900
“[1] Furthermore, recent studies have shown measurable”
Self-citationHow placebo responses are formed: a learning perspective
Colloca, L., & Miller, F. G. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0398 · Cited by 323
Self-citationEnhance placebo, avoid nocebo: How contextual factors affect physiotherapy outcomes
Testa, M., & Rossettini, G. (2016) · Manual Therapy · doi:10.1016/j.math.2016.04.006 · Cited by 256
Role of expectations in health
Colloca, L., & Miller, F. G. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328343803b · Cited by 161
Self-citationPlacebo effect studies are susceptible to response bias and to other types of biases
Hróbjartsson, A., Kaptchuk, T. J., & Miller, F. G. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.008 · Cited by 150
“[13] Miller FG, Colloca L, Kaptchuk TJ.”
BackgroundSelf-citation
Metadata
- Authors
- Miller, F. G., Colloca, L., & Kaptchuk, T. J.
- Venue
- Perspectives in Biology and Medicine
- Publisher
- Project MUSE
- Published
- 2009-09
- Volume
- 52
- Issue
- 4
- Pages
- 518-539
- ISSN
- 0031-5982 (ISSN-L)
- 1529-8795
- OpenAlex
- W2072633755
- Cited by
- 254
- References
- 110
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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