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Cited by 189Influenza Virus Research StudiesVirology and Viral DiseasesVagus Nerve Stimulation Research

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

The Vagus Nerve is One Route of Transneural Invasion for Intranasally Inoculated Influenza A Virus in Mice

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Matsuda, K., Park, C. H., Sunden, Y., Kimura, T., Ochiai, K., Kida, H., Umemura, T.·2004·Veterinary Pathology
DOI 10.1354/vp.41-2-101
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Abstract

Intranasally inoculated neurotropic influenza viruses in mice infect not only the respiratory tract but also the central nervous system (CNS), mainly the brain stem. 26 , 34 Previous studies suggested that the route of invasion of virus into the CNS was via the peripheral nervous system, especially the vagus nerve. To evaluate the transvagal transmission of the virus, we intranasally inoculated unilaterally vagectomized mice with a virulent influenza virus (strain 24a5b) and examined the distribution of the viral protein and genome by immunohistochemistry and in situ hybridization over time. An asymmetric distribution of viral antigens was observed between vagal (nodose) ganglia: viral antigen was detected in the vagal ganglion of the vagectomized side 2 days later than in the vagal ganglion of the intact side. The virus was apparently transported from the respiratory mucosa to the CNS directly and decussately via the vagus nerve and centrifugally to the vagal ganglion of the vagectomized side. The results of this study, thus, demonstrate that neurotropic influenza virus travels to the CNS mainly via the vagus nerve.

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Citations

Cites

Research works printed but not linked: 5

  1. Andries K, 1980, Am J Vet Res, 41, 1372
  2. Reinacher M, 1983, Lab Invest, 49, 686
  3. Renegar KB, 1992, Lab Anim Sci, 42, 222
  4. Tyler KL, 1997, Viral Pathogenesis, 837
  5. Von Economo C, 1917, Wien Klin Weshr, 30, 581

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Metadata

Authors
Matsuda, K., Park, C. H., Sunden, Y., Kimura, T., Ochiai, K., Kida, H., & Umemura, T.
Affiliations
Hokkaido University (JP)
Corresponding author
Umemura, T.
ORCID
Venue
Veterinary Pathology
Publisher
SAGE Publications
Published
2004-03
Volume
41
Issue
2
Pages
101-107
ISSN
  • 0300-9858 (ISSN-L)
  • 1544-2217
DOI
10.1354/vp.41-2-101
OpenAlex
W2105165121
Cited by
189
References
42
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 12 · 2022: 18 · 2021: 39 · 2020: 71 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 5
FWCI
2.14
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Veterinary Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
influenza A virus, vagus nerve, central nervous system infection, nodose ganglion, peripheral nervous system, viral dissemination, mouse model
MeSH terms
Animals, Brain Stem, Immunohistochemistry, Lung, Nodose Ganglion, Orthomyxoviridae Infections, Influenza A virus, Vagus Nerve, In Situ Hybridization, Respiratory Mucosa, Mice

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