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Micronization: A method of improving the bioavailability of poorly soluble drugs
Abstract
For poorly soluble drugs, the digestive absorption depends on their rate of dissolution. Decreasing the particle size of these drugs improves their rate of dissolution. Fine grinding mills are use to micronize powders: either jar mills or fluid energy mills. Theses processes were applied to griseofulvin, progesterone, spironolactone and diosmin. For each drug, micronization improved their digestive absorption, and consequently their bioavailability and clinical efficacy.
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Citations
Cited by
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
Blagden, N., de Matas, M., Gavan, P. T., & York, P. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.011 · Cited by 1,448
Xu, W., Ling, P., & Zhang, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/340315 · Cited by 595
Polymeric micelles for oral drug delivery
Gaucher, G., Satturwar, P., Jones, M.-C., Furtos, A., & Leroux, J.-C. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.06.007 · Cited by 389
Aakeröy, C. B., Forbes, S., & Desper, J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja907674c · Cited by 297
Metadata
- Authors
- Chaumeil, J. C.
- Venue
- Methods and Findings in Experimental and Clinical Pharmacology
- Publisher
- Portico
- Published
- 1998
- Volume
- 20
- Issue
- 3
- Pages
- 211
- ISSN
- 0379-0355 (ISSN-L)
- 2013-0155
- OpenAlex
- W2417566118
- Cited by
- 242
- References
- 0
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Micronization: A method of improving the bioavailability of poorly soluble drugs. https://app.cochat.ai/papers/10.1358/mf.1998.20.3.485666
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- Chaumeil, J. C. (1998). Micronization: A method of improving the bioavailability of poorly soluble drugs. Methods and Findings in Experimental and Clinical Pharmacology. https://doi.org/10.1358/mf.1998.20.3.485666
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
