Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

Bertolini, D. R., Nedwin, G. E., Bringman, T. S., Smith, D. D., & Mundy, G. R. (1986) · Nature · doi:10.1038/319516a0 · Cited by 1,425 · see citing works

Dickkopf-1 is a master regulator of joint remodeling

Diarra, D., Stolina, M., Polzer, K., Zwerina, J., Ominsky, M. S., Dwyer, D., Korb, A., Smolen, J. S., Hoffmann, M. H., Scheinecker, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1538 · Cited by 1,296 · see citing works

Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis

AI-Aql, Z. S., Alagl, A. S., Graves, D. T., Gerstenfeld, L. C., & Einhorn, T. A. (2008) · Journal of Dental Research · doi:10.1177/154405910808700215 · Cited by 689 · see citing works

A Twist Code Determines the Onset of Osteoblast Differentiation

Bialek, P., Kern, B., Yang, X., Schrock, M., Šošić, D., Hong, N. A., Wu, H., Yu, K., Ornitz, D. M., Olson, E. N., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00058-9 · Cited by 674 · see citing works

Tumor necrosis factor-α: molecular and cellular mechanisms in skeletal pathology

Nanes, M. S. (2003) · Gene · doi:10.1016/s0378-1119(03)00841-2 · Cited by 440 · see citing works

Tumor Necrosis Factor-α Mediates Orthopedic Implant Osteolysis

Merkel, K. D., Erdmann, J. M., McHugh, K. P., Abu‐Amer, Y., Ross, F. P., & Teitelbaum, S. L. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65266-2 · Cited by 370 · see citing works

Angiotensin II Induces Premature Senescence of Vascular Smooth Muscle Cells and Accelerates the Development of Atherosclerosis via a p21-Dependent Pathway

Kunieda, T., Minamino, T., Nishi, J.-I., Tateno, K., Oyama, T., Katsuno, T., Miyauchi, H., Orimo, M., Okada, S., Takamura, M., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.626606 · Cited by 302 · see citing works

Fracture healing in the elderly patient

Gruber, R., Koch, H., Doll, B. A., Tegtmeier, F. T., Einhorn, T. A., & Hollinger, J. O. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.008 · Cited by 284 · see citing works

The Wnt Signaling Inhibitor Dickkopf-1 Is Required for Reentry into the Cell Cycle of Human Adult Stem Cells from Bone Marrow

Gregory, C. A., Singh, H., Perry, A. S., & Prockop, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300373200 · Cited by 283 · see citing works

Estrogen Deficiency Increases the Ability of Stromal Cells to Support Murine Osteoclastogenesis via an Interleukin-1and Tumor Necrosis Factor-mediated Stimulation of Macrophage Colony-stimulating Factor Production

Kimble, R. B., Srivastava, S., Ross, F. P., Matayoshi, A., & Pacifici, R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.28890 · Cited by 272 · see citing works

Inflammatory bone destruction and osteoimmunology

Takayanagi, H. (2005) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2005.00814.x · Cited by 267 · see citing works

Inflammatory Markers and Incident Fracture Risk in Older Men and Women: The Health Aging and Body Composition Study

Cauley, J. A., Danielson, M. E., Boudreau, R. M., Forrest, K. Y. Z., Zmuda, J. M., Pahor, M., Tylavsky, F. A., Cummings, S. R., Harris, T. B., & Newman, A. B. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070409 · Cited by 262 · see citing works

Effect of Blockade of TNF‐α and Interleukin‐1 Action on Bone Resorption in Early Postmenopausal Women

Charatcharoenwitthaya, N., Khosla, S., Atkinson, E. J., McCready, L., & Riggs, B. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070207 · Cited by 239 · see citing works

Impaired Intramembranous Bone Formation during Bone Repair in the Absence of Tumor Necrosis Factor-Alpha Signaling

Gerstenfeld, L. C., Cho, T.-J., Kon, T., Aizawa, T., Cruceta, J., Graves, B., & Einhorn, T. A. (2001) · Cells Tissues Organs · doi:10.1159/000047893 · Cited by 236 · see citing works

Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-κB

Aggarwal, B. B. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.suppl_1.i6 · Cited by 234 · see citing works

p21^WAF1/Cip1 is a negative transcriptional regulator of <i>Wnt4</i> expression downstream of Notch1 activation

Devgan, V., Mammucari, C., Millar, S. E., Brisken, C., & Dotto, G. P. (2005) · Genes &amp; Development · doi:10.1101/gad.341405 · Cited by 209 · see citing works

The human cost of fracture

Pasco, J. A., Sanders, K. M., Hoekstra, F. M., Henry, M. J., Nicholson, G. C., & Kotowicz, M. A. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1997-y · Cited by 184 · see citing works

Endogenous TNFα Lowers Maximum Peak Bone Mass and Inhibits Osteoblastic Smad Activation Through NF-κB

Li, Y., Li, A., Strait, K. R., Zhang, H., Nanes, M. S., & Weitzmann, M. N. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070121 · Cited by 181 · see citing works

Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

Fujita, K.-I., & Janz, S. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-71 · Cited by 178 · see citing works

Bone Formation Is Impaired in a Model of Type 1 Diabetes

Thrailkill, K. M., Liu, L., Wahl, E. C., Bunn, R. C., Perrien, D. S., Cockrell, G. E., Skinner, R. A., Hogue, W. R., Carver, A. A., Fowlkes, J. L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2875 · Cited by 172 · see citing works

Bone mass is inversely proportional to Dkk1 levels in mice

MacDonald, B. T., Joiner, D. M., Oyserman, S. M., Sharma, P., Goldstein, S. A., He, X., & Hauschka, P. V. (2007) · Bone · doi:10.1016/j.bone.2007.05.009 · Cited by 169 · see citing works

Infected Nonunion of the Long Bones

Jain, A., & Sinha, S. (2005) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000152868.29134.92 · Cited by 165 · see citing works

Osteogenic Differentiation of Mouse Embryonic Stem Cells and Mouse Embryonic Fibroblasts in a Three-Dimensional Self-Assembling Peptide Scaffold

Garreta, E., Genové, E., Borrós, S., & Semino, C. E. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.2215 · Cited by 158 · see citing works

The role of angiogenesis in a murine tibial model of distraction osteogenesis

Carvalho, R. S., Einhorn, T. A., Lehmann, W., Edgar, C. M., Alyamani, A., Apazidis, A., Pacicca, D. M., Clemens, T. L., & Gerstenfeld, L. C. (2004) · Bone · doi:10.1016/j.bone.2003.12.027 · Cited by 153 · see citing works

GENE EXPRESSION IN OLDER RATS WITH DELAYED UNION OF FEMORAL FRACTURES

Meyer, R. A., Meyer, M. H., Tenholder, M., WONDRACEK, S., WASSERMAN, R., & Garges, P. L. (2003) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200307000-00010 · Cited by 139 · see citing works

Transcriptional Regulation of the Osterix (Osx, Sp7) Promoter by Tumor Necrosis Factor Identifies Disparate Effects of Mitogen-activated Protein Kinase and NFκB Pathways

Lu, X., Gilbert, L. C., He, X., Rubin, J. E., & Nanes, M. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m507804200 · Cited by 135 · see citing works

The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis

Gilbert, L. C., Rubin, J. E., & Nanes, M. S. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00534.2004 · Cited by 124 · see citing works

Circulating Levels of Insulin-Like Growth Factor (IGF) Binding Protein-1 and -3 in Aging Men: Relationships to Insulin, Glucose, IGF, and Dehydroepiandrosterone Sulfate Levels and Anthropometric Measures

Benbassat, C. A., Maki, K. C., & Unterman, T. G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3930 · Cited by 115 · see citing works

Cell Cycle-dependent Phosphorylation of the RUNX2 Transcription Factor by cdc2 Regulates Endothelial Cell Proliferation

Qiao, M., Shapiro, P. S., Fosbrink, M. D., Rus, H., Kumar, R., & Passaniti, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508162200 · Cited by 114 · see citing works

Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study

Sasaki, M., Ikeda, H., Sato, Y., & Nakanuma, Y. (2008) · Free Radical Research · doi:10.1080/10715760802244768 · Cited by 90 · see citing works

A review of 240 patients undergoing distraction osteogenesis for congenital post-traumatic or postinfective lower limb length discrepancy.

Maffulli, N., Lombari, C., Matarazzo, L., Nele, U., Pagnotta, G., & Fixsen, J. A. (1996) · PubMed · Cited by 87 · see citing works

Rat model of distraction osteogenesis

Aronson, J., Shen, X. C., Skinner, R. A., Hogue, W. R., Badger, T. M., & Lumpkin, C. K. (1997) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100150210 · Cited by 84 · see citing works

Skeletal Effects of Developmental Lead Exposure in Rats

Ronis, M. J. J. (2001) · Toxicological Sciences · doi:10.1093/toxsci/62.2.321 · Cited by 84 · see citing works

Integration of the NfκB p65 subunit into the vitamin D receptor transcriptional complex: Identification of p65 domains that inhibit 1,25‐dihydroxyvitamin D3‐stimulated transcription

Lu, X., FARMER, P. K., Rubin, J. E., & Nanes, M. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20143 · Cited by 80 · see citing works

Inflammatory cytokines regulate proliferation of cultured human osteoblasts

Frost, A., Jonsson, K. B., Nilsson, O., & Ljunggren, Ö. (1997) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679709003987 · Cited by 78 · see citing works

Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts

Chen, J., Lazarenko, O. P., Haley, R. L., Blackburn, M. L., Badger, T. M., & Ronis, M. J. J. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081011 · Cited by 78 · see citing works

Histochemical and molecular analyses of distraction osteogenesis in a mouse model

Tay, B. K.-B., Le, A. X., Gould, S. E., & Helms, J. A. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160518 · Cited by 76 · see citing works

The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-α–induced transcriptional repression of cyclin A

Kishore, R., Qin, G., Luedemann, C., Bord, E., Hanley, A., Silver, M., Gavin, M., Goukassain, D., & Losordo, D. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22849 · Cited by 76 · see citing works

Effects of Systemic and Local Administration of Recombinant Human IGF-I (rhIGF-I) on De Novo Bone Formation in an Aged Mouse Model

Fowlkes, J. L., Thrailkill, K. M., Liu, L., Wahl, E. C., Bunn, R. C., Cockrell, G. E., Perrien, D. S., Aronson, J., & Lumpkin, C. K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060618 · Cited by 73 · see citing works

High Serum IGFBP-2 Is Predictive of Increased Bone Turnover in Aging Men and Women

Amin, S., Riggs, B. L., Melton, L. J., Achenbach, S. J., Atkinson, E. J., & Khosla, S. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070306 · Cited by 69 · see citing works

Stress fracture healing: Fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair

Wohl, G. R., Towler, D. A., & Silva, M. J. (2008) · Bone · doi:10.1016/j.bone.2008.09.010 · Cited by 68 · see citing works

Sustained proliferation accompanies distraction osteogenesis in the rat

Aronson, J., Shen, X. C., Gao, G. G., Miller, F., Quattlebaum, T., Skinner, R. A., Badger, T. M., & Lumpkin, C. K. (1997) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100150412 · Cited by 67 · see citing works

Osteoneogenesis and Its Influencing Factors During Treatment With the Ilizarov Method

Fink, B., Krieger, M., Strauss, J. M., Opheys, C., Menkhaus, S., Fischer, J., & R??ther, W. (1996) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199602000-00036 · Cited by 63 · see citing works

Inhibitory effects of tumor necrosis factor alpha on fracture healing in rats

Hashi­moto, J., Yoshikawa, H., Takaoka, K., Shimizu, N., Masuhara, K., Tsuda, T., Miyamoto, S., & Ono, K. (1989) · Bone · doi:10.1016/8756-3282(89)90078-1 · Cited by 62 · see citing works

The osteogenic-angiogenic interface: Novel insights into the biology of bone formation and fracture repair

Towler, D. A. (2008) · Current Osteoporosis Reports · doi:10.1007/s11914-008-0012-x · Cited by 58 · see citing works

Management of nonunion with distraction osteogenesis

Kanellopoulos, A. D., & Soucacos, P. N. (2006) · Injury · doi:10.1016/j.injury.2006.02.041 · Cited by 57 · see citing works

p21WAF1/CIP1 Acts as a Brake in Osteoblast Differentiation

Bellosta, P., Masramon, L., Mansukhani, A., & Basilico, C. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.5.818 · Cited by 56 · see citing works

The effect of aging on distraction osteogenesis in the rat

Aronson, J., Gao, G. G., Shen, X. C., McLaren, S. G., Skinner, R. A., Badger, T. M., & Lumpkin, C. K. (2001) · Journal of Orthopaedic Research® · doi:10.1016/s0736-0266(00)90025-1 · Cited by 54 · see citing works

Immunohistochemical Study of Osteopontin Expression During Distraction Osteogenesis in the Rat

Perrien, D. S., Brown, E. C., Aronson, J., Skinner, R. A., Montague, D. C., Badger, T. M., & Lumpkin, C. K. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000414 · Cited by 51 · see citing works

The Retinoblastoma Protein Is an Essential Mediator of Osteogenesis That Links the p204 Protein to the Cbfa1 Transcription Factor Thereby Increasing Its Activity

Luan, Y., Yu, X., Xu, K., Ding, B., Yu, J. H., Huang, Y., Yang, N., Lengyel, P., Cesare, P. E. D., & Liu, C.-J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610943200 · Cited by 48 · see citing works

A murine model of distraction osteogenesis

Isefuku, S., Joyner, C. J., & Simpson, H. (2000) · Bone · doi:10.1016/s8756-3282(00)00385-9 · Cited by 43 · see citing works

IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats

Perrien, D. S. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfi002 · Cited by 40 · see citing works

Bone formation after damaging in vivo fatigue loading results in recovery of whole‐bone monotonic strength and increased fatigue life

Silva, M. J., & Touhey, D. C. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20320 · Cited by 35 · see citing works

Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: Role of the TNF signaling axis

Wahl, E. C., Aronson, J., Liu, L., Liu, Z., Perrien, D. S., Skinner, R. A., Badger, T. M., Ronis, M. J. J., & Lumpkin, C. K. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.02.011 · Cited by 34 · see citing works

Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system

Kim, T. W., Kim, H. J., Lee, C., Kim, H. Y., Baek, S., Kim, J. H., Kwon, K., & Kim, J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.010 · Cited by 29 · see citing works

Ethanol Modulation of TNF-alpha Biosynthesis and Signaling in Endothelial Cells: Synergistic Augmentation of TNF-alpha Mediated Endothelial Cell Dysfunctions by Chronic Ethanol

Luedemann, C., Bord, E., Qin, G., Zhu, Y., Goukassian, D. A., Losordo, D. W., & Kishore, R. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000171037.90100.6b · Cited by 24 · see citing works

Genes with greater up‐regulation in the fracture callus of older rats with delayed healing

Meyer, M. H., & Meyer, R. A. (2007) · Journal of Orthopaedic Research® · doi:10.1002/jor.20334 · Cited by 21 · see citing works

TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells.

Suffys, P. N., Beyaert, R., Roy, F. M. V., & Fiers, W. (1989) · PubMed · Cited by 21 · see citing works

p21WAF1/CIP1 Inhibits Cell Cycle Progression but Not G2/M-Phase Transition Following Methylmercury Exposure

Mendoza, M. A. C., Ponce, R. A., Ou, Y. C., & Faustman, E. M. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9267 · Cited by 19 · see citing works

Decreased Endosteal Intramembranous Bone Formation Accompanies Aging in a Mouse Model of Distraction Osteogenesis

Aronson, J., Liu, L., Liu, Z., Gao, G. G., Perrien, D. S., Brown, E. C., Skinner, R. A., Thomas, J. R., Morris, K. D., Suva, L. J., et al. (2002) · e-biomed The Journal of Regenerative Medicine · doi:10.1089/152489002760269667 · Cited by 17 · see citing works

Ethanol-Induced Inhibition of Bone Formation in a Rat Model of Distraction Osteogenesis: A Role for the Tumor Necrosis Factor Signaling Axis

Wahl, E. C., Perrien, D. S., Aronson, J., Liu, Z., Fletcher, T. W., Skinner, R. A., Feige, U., Suva, L. J., Badger, T. M., & Lumpkin, C. K. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000174695.09579.11 · Cited by 17 · see citing works

Osteoporosis in men: pathophysiology, evaluation, and therapy

Burgess, E., & Nanes, M. S. (2002) · Current Opinion in Rheumatology · doi:10.1097/00002281-200207000-00016 · Cited by 11 · see citing works

Responsiveness of Single Afferents in the Infraorbital Nerve to Oral Air Pressures Generated by Consonants

Furusawa, K., Yamaoka, M., & Ichikawa, N. (1994) · The Cleft Palate-Craniofacial Journal · doi:10.1597/1545-1569(1994)031 · Cited by 3 · see citing works

TNF in combination with interferon-γ is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells

Suffys, P. N., Beyaert, R., van Roy, F., & Fiers, W. (1989) · Ghent University Academic Bibliography (Ghent University) · Cited by 3 · see citing works

Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis

Locatelli, V., & Bianchi, V. E. (2014) · International Journal of Endocrinology · doi:10.1155/2014/235060 · Cited by 318 · see citing works

Mesenchymal stem cells: Amazing remedies for bone and cartilage defects

Kangari, P., Talaei-Khozani, T., Razeghian-Jahromi, I., & Razmkhah, M. (2020) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-020-02001-1 · Cited by 286 · see citing works

The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis

Weitzmann, M. (2013) · Scientifica · doi:10.1155/2013/125705 · Cited by 270 · see citing works

Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency–induced osteoporosis

Yang, N., Wang, G., Hu, C., Shi, Y., Liao, L., Shi, S., Cai, Y., Cheng, S.-L., Wang, X., Liu, Y., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1798 · Cited by 258 · see citing works

Osteoblasts in osteoporosis: Past, emerging, and future anabolic targets

Marie, P. J., & Kassem, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0132 · Cited by 234 · see citing works

Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation

Yamaguchi, M., & Weitzmann, M. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0852-z · Cited by 212 · see citing works

Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence

Saul, D., & Khosla, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac008 · Cited by 185 · see citing works

A tissue engineering approach based on the use of bioceramics for bone repair

Salinas, A. J., Esbrit, P., & Vallet‐Regí, M. (2012) · Biomaterials Science · doi:10.1039/c2bm00071g · Cited by 157 · see citing works

Inflammaging: The driving force in osteoporosis?

Lencel, P., & Magne, D. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.09.023 · Cited by 141 · see citing works

The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease

Hadjiargyrou, M., & O’Keefe, R. J. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2373 · Cited by 126 · see citing works

Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation

Yamaguchi, M. (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2010.562 · Cited by 115 · see citing works

Multiple roles of tumor necrosis factor-alpha in fracture healing.

Karnes, J. M., Daffner, S., & Watkins, C. (2015) · Bone · doi:10.1016/j.bone.2015.05.001 · Cited by 82 · see citing works

Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment

Yukata, K., Xie, C. L., Li, T.-F., Takahata, M., Hoak, D., Kondabolu, S., Zhang, X., Awad, H. A., Schwarz, E. M., Beck, C. A., et al. (2014) · Bone · doi:10.1016/j.bone.2014.02.002 · Cited by 82 · see citing works

Biology of Tendon Stem Cells and Tendon in Aging

Lui, P. P. Y., & Wong, C. M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2019.01338 · Cited by 76 · see citing works

The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation

Yamaguchi, M., & Weitzmann, M. N. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1034-8 · Cited by 76 · see citing works

Effects of Anti-Tumor Necrosis Factor α (anti-TNF) agents on Bone

Kawai, V., Stein, C. M., Perrien, D., & Griffin, M. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328356d212 · Cited by 63 · see citing works

Pulp Revascularization on Permanent Teeth with Open Apices in a Middle-aged Patient

Wang, Y., Zhu, X., & Zhang, C. (2015) · Journal of Endodontics · doi:10.1016/j.joen.2015.04.022 · Cited by 62 · see citing works

B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice

Weitzmann, M. N., Li, Y., Terauchi, M., Vikulina, T., & Roser‐Page, S. (2015) · The Open Bone Journal · doi:10.2174/1876525401406010008 · Cited by 55 · see citing works

H 2 O 2 Accumulation Mediates Differentiation Capacity Alteration, But Not Proliferative Decline, in Senescent Human Fetal Mesenchymal Stem Cells

Ho, P.-J., Yen, M., Tang, B.-C., Chen, C., & Yen, B. L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4692 · Cited by 54 · see citing works

Effect of TNFα on osteoblastogenesis from mesenchymal stem cells

Kotake, S., & Nanke, Y. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.12.013 · Cited by 53 · see citing works

Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts

Weitzmann, M. N. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.749 · Cited by 52 · see citing works

Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone

Thrailkill, K. M., Bunn, R. C., Lumpkin, C. K., Wahl, E. C., Cockrell, G. E., Morris, L. M., Kahn, C. R., Fowlkes, J. L., & Nyman, J. S. (2014) · Journal of Diabetes Research · doi:10.1155/2014/703589 · Cited by 48 · see citing works

Deregulation of Bone Forming Cells in Bone Diseases and Anabolic Effects of Strontium-Containing Agents and Biomaterials

Tan, S., Zhang, B.-B., Zhu, X., Ao, P., Guo, H., Yi, W., & Zhou, G. (2014) · BioMed Research International · doi:10.1155/2014/814057 · Cited by 46 · see citing works

Chronic low dose tumor necrosis factor-α (TNF) suppresses early bone accrual in young mice by inhibiting osteoblasts without affecting osteoclasts

Gilbert, L. C., Chen, H., Lu, X., & Nanes, M. S. (2013) · Bone · doi:10.1016/j.bone.2013.06.002 · Cited by 43 · see citing works

High dose 1,25(OH)2D3 inhibits osteoblast mineralization in vitro

Weitzmann, M. N. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.900 · Cited by 42 · see citing works

Implants for the aged patient: biological, clinical and sociological considerations

Bartold, P. M., Ivanovski, S., & Darby, I. B. (2016) · Periodontology 2000 · doi:10.1111/prd.12133 · Cited by 42 · see citing works

Assessing the Effects of Teriparatide Treatment on Bone Mineral Density, Bone Microarchitecture, and Bone Strength

Kleerekoper, M., Greenspan, S. L., Lewiecki, E. M., Miller, P. D., Kendler, D. L., Maricic, M. J., Keaveny, T. M., Kopperdahl, D. L., Ruff, V. A., Wan, X., et al. (2014) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.l.01757 · Cited by 36 · see citing works

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

Zhao, S., Qiao, Z., Pfeifer, R., Pape, H.-C., Mao, K., Tang, H., Meng, B., Chen, S., & Liu, H. (2024) · European Journal of Medical Research · doi:10.1186/s40001-023-01604-7 · Cited by 35 · see citing works

The bone anabolic carotenoid p-hydroxycinnamic acid promotes osteoblast mineralization and suppresses osteoclast differentiation by antagonizing NF-κB activation.

Yamaguchi, M., & Weitzmann, M. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1043 · Cited by 34 · see citing works

Surface contaminants inhibit osseointegration in a novel murine model

Bonsignore, L. A., Colbrunn, R., Tatro, J. M., Messerschmitt, P. J., Hernandez, C. J., Goldberg, V. M., Stewart, M. C., & Greenfield, E. M. (2011) · Bone · doi:10.1016/j.bone.2011.07.013 · Cited by 31 · see citing works

Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing

Oranger, A., Zerlotin, R., Buccoliero, C., Sanesi, L., Storlino, G., Schipani, E., Kozloff, K. M., Mori, G., Colaianni, G., Colucci, S. C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031809 · Cited by 28 · see citing works

Rodent Models of Aging Bone: An Update

Syed, F. A., & Melim, T. L. (2011) · Current Osteoporosis Reports · doi:10.1007/s11914-011-0074-z · Cited by 27 · see citing works

The role of PGRN in musculoskeletal development and disease

Konopka, J. (2014) · Frontiers in bioscience · doi:10.2741/4234 · Cited by 25 · see citing works

Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation

Yamaguchi, M. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.786 · Cited by 24 · see citing works

The role of the microenvironment on the fate of adult stem cells

Dong, L., Hao, H., Han, W., & Fu, X. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4865-9 · Cited by 21 · see citing works

Inflammatory Profile and Osteogenic Potential of Fracture Haematoma in Humans

Pountos, I., Walters, G. E., Panteli, M., Einhorn, T. A., & Giannoudis, P. V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010047 · Cited by 21 · see citing works

Proinflammatory Cytokines Regulate Cementogenic Differentiation of Periodontal Ligament Cells by Wnt/Ca 2+ Signaling Pathway

Han, P., Lloyd, T., Chen, Z., & Xiao, Y. (2016) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0111 · Cited by 18 · see citing works

Direct bone formation during distraction osteogenesis does not require TNFα receptors and elevated serum TNFα fails to inhibit bone formation in TNFR1 deficient mice

Wahl, E. C., Aronson, J., Liu, L., Skinner, R. A., Miller, M. J., Cockrell, G. E., Fowlkes, J. L., Thrailkill, K. M., Bunn, R. C., Ronis, M. J. J., et al. (2009) · Bone · doi:10.1016/j.bone.2009.09.011 · Cited by 16 · see citing works

TNF-α modulation via Etanercept restores bone regeneration of atrophic non-unions

Wagner, J. M., Schmidt, S. V., Dadras, M., Wallner, C., Huber, J., Sogorski, A., Sacher, M., Reinkemeier, F., Dittfeld, S., Becerikli, M., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115569 · Cited by 13 · see citing works

Paracrine effects of haematopoietic cells on human mesenchymal stem cells

Zhou, S. (2015) · Scientific Reports · doi:10.1038/srep10573 · Cited by 13 · see citing works

Redundant let‐7a suppresses the immunomodulatory properties of BMSCs by inhibiting the Fas/FasL system in osteoporosis

Liao, L., Yu, Y., Shao, B.-Y., Su, X.-X., Wang, H., Kuang, H., Jing, H., Situai, Y., Yang, D.-Q., & Jin, Y. (2017) · The FASEB Journal · doi:10.1096/fj.201700885r · Cited by 14 · see citing works

Osteoimmunology and the Osteoblast

Nanes, M. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00005-0 · Cited by 10 · see citing works

Nutlin‐3 treatment spares cisplatin‐induced inhibition of bone healing while maintaining osteosarcoma toxicity

Stine, K. C., Wahl, E. C., Liu, L., Skinner, R. A., VanderSchilden, J., Bunn, R. C., Montgomery, C. O., Aronson, J., Becton, D. L., Nicholas, R. W., et al. (2016) · Journal of Orthopaedic Research® · doi:10.1002/jor.23192 · Cited by 9 · see citing works

Distraction osteogenesis in TNF receptor 1 deficient mice is protected from chronic ethanol exposure

Wahl, E. C., Aronson, J., Liu, L., Skinner, R. A., Ronis, M. J. J., & Lumpkin, C. K. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.08.007 · Cited by 8 · see citing works

The role and mechanism of tumor necrosis factor-alpha in alcohol-induced bone loss

Wang, X., Lu, L., Chen, X., Liang, Y., Xie, Y., & Yu, X. (2023) · Alcohol and Alcoholism · doi:10.1093/alcalc/agad026 · Cited by 7 · see citing works

Osteoporosis and Mechanisms of Skeletal Aging

Glowacki, J., & Vokes, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_10 · Cited by 6 · see citing works

Animal Models of Bone Disease-B

McGee‐Lawrence, M. E., Secreto, F. J., & Syed, F. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415894-8.00017-8 · Cited by 6 · see citing works

Murine Supraspinatus Tendons Demonstrate Aging‐Related Changes in Multiscale Mechanics, Structure, and Gene Expression

DiStefano, M. S., Eekhoff, J. D., Weiss, S. N., Nuss, C. A., Betts, R. L., Kuntz, A. F., & Soslowsky, L. J. (2025) · Journal of Orthopaedic Research® · doi:10.1002/jor.70013 · Cited by 5 · see citing works

Nouveaux acteurs du remodelage osseux, rôle du système immunitaire

Thomas, T. (2010) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)32179-x · Cited by 5 · see citing works

Spontaneous Healing Capacity of Calvarial Bone Defects inmdxMice

Nakagaki, W. R., & Camilli, J. Â. (2012) · The Anatomical Record · doi:10.1002/ar.22412 · Cited by 4 · see citing works

Hydroxylated fullerene promotes fracture healing in ovariectomized combined type 2 diabetic mice

Hu, Y., Feng, L., Li, J., Cao, F., Hou, X. S., Chen, W., Zhang, Y., Xing, L., Gao, J., Zhang, L., et al. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05997-5 · Cited by 2 · see citing works

Metabolic Endotoxemia and Inhibition of Direct Bone Regeneration: A Pilot Study

Wahl, E. (2012) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2012/1547 · Cited by 1 · see citing works

Counts of MSC in the Bone Marrow of Young and Old CBA Mice after a Single Exposure to Osteogenic Stimuli (Curettage, BMP-2 Injection) or Antigens (S. typhimurium Antigenic Complex) and in Heterotopic Bone Marrow Transplants

Gorskaya, Y. F., Dzharullaeva, A. S., Onsina, D. S., & Нестеренко, В. Г. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3805-z · Cited by 1 · see citing works

Molecular Mechanisms Underlying the Actions of Dietary Factors on the Skeleton

Ronis, M. J. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397155-5.00006-4

Involvement of Bone Marrow Multipotent Stromal Cells in the Processes Presumably Provoking Vascular Calcification

Gorskaya, Y. F., Semenova, É. N., NAGURSKAYA, E. V., & Нестеренко, В. Г. (2020) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-020-04735-7

Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing

Huang, M., Balu, A. R., Molitoris, K. H., Bareja, A., & Baht, G. S. (2026) · Bone Research · doi:10.1038/s41413-025-00489-y

ORIGINAL ARTICLE JBMR Restoration of Regenerative Osteoblastogenesis in Aged Mice: Modulation of TNF

Wahl, E. C., Aronson, J., Liu, L., Fowlkes, J. L., Thrailkill, K. M., Bunn, R. C., Skinner, R. A., Miller, M. J., Cockrell, G. E., Clark, L. M., et al. (2013)

Chronic low dose tumor necrosis factor-α (TNF) suppresses early bone accrual in young mice by inhibiting osteoblasts without affecting osteoclasts

Gilbert, L. C., Chen, H., Lu, X., & Nanes, M. S. (2013) · Bone · doi:10.1016/j.bone.2013.06.002 · Cited by 43 · see citing works

Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation

Lu, Z., Wang, G., Dunstan, C. R., & Zreiqat, H. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0589 · Cited by 79 · see citing works

Decreased osteogenesis in mesenchymal stem cells derived from the aged mouse is associated with enhanced NF‐κB activity

Lin, T., Gibon, E., Loi, F., Pajarinen, J., Córdova, L. A., Nabeshima, A., Lu, L. Y., Yao, Z., & Goodman, S. B. (2016) · Journal of Orthopaedic Research® · doi:10.1002/jor.23270 · Cited by 69 · see citing works

TNF-α Mediates p38 MAP Kinase Activation and Negatively Regulates Bone Formation at the Injured Growth Plate in Rats

Zhou, F. H., Foster, B. K., Zhou, X., Cowin, A. J., & Xian, C. J. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060410 · Cited by 134 · see citing works