Bone Mineral and Body Composition Measurements: Cross-Calibration of Pencil-Beam and Fan-Beam Dual-Energy X-Ray Absorptiometers
Abstract
Pencil-beam dual-energy X-ray absorptiometers (DXA) are being replaced with instruments that rely solely on fan-beam technology. However, information has been lacking regarding the translation of bone mineral and body composition data between the two devices. We have compared total body scans using pencil-beam (Hologic QDR-2000W) and fan-beam (Hologic QDR-4500A) instruments for 33 children (ages 3–18 years) and 14 adults. Bone mineral content (BMC), bone mineral density (BMD), fat, lean, and body fatness (%fat) values were highly correlated (r2 = 0.984–0.998) between the two DXA instruments. The mean differences between the paired measurements were: ΔBMC = 7.5 ± 73.6 g, ΔBMD = 0.0074 ± 0.0252 g/cm2, Δlean = 1.05 ± 1.8 kg, Δfat = −0.77 ± 1.7 kg, and Δ%fat = −0.94% ± 2.5%. The BMC and BMD values were not statistically different, whereas the differences for the body composition values were significant (p < 0.02–0.005). Regression equations are provided for conversion of bone and body composition data between pencil-beam and fan-beam values for the whole body. To test the performance of these equations for a second group (23 subjects), predicted values were compared with the measured data obtained using the fan-beam instrument. The mean differences were −1.0% to 1.4%, except for body fat mass, where the difference was 6.4%. For cross-sectional studies, the two DXA technologies can be considered equivalent after using the translational equations provided. For longitudinal studies in which small changes in body composition for the individual are to be detected, we recommend that the same DXA instrument be used whenever possible. For example, transition from a pencil-beam to a fan-beam instrument could, in extreme cases, result in differences as large as 19% for the estimate of body fat mass.
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Differences in intra- and inter-manufacturer DXA estimates are small.
“Studies have shown that the differences in intraand inter-manufacturer estimates are small (11,14 -16).”
From Comparison of Body Composition Methods in Obese African‐American Women (2006) · cites this paper as [11]
DXA estimates of %BF are accurate, but values can differ by DXA instrumentation.
“Estimates of %BF are also accurate (11)(12)(13), but values can differ based on the DXA instrumentation utilized (e.g., Lunar, Hologic, Norland).”
From Comparison of Body Composition Methods in Obese African‐American Women (2006) · cites this paper as [11]
DXA provides accurate estimates of bone mineral content and bone mineral density.
“The DXA method has been shown to provide accurate estimates of bone mineral content and bone mineral density (11).”
From Comparison of Body Composition Methods in Obese African‐American Women (2006) · cites this paper as [11]
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Comparison of Body Composition Methods in Obese African‐American Women
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- Authors
- Ellis, K. J., & Shypailo, R. J.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Ellis, Kenneth J.
- ORCID
- Shypailo, Roman J.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-10-01
- Volume
- 13
- Issue
- 10
- Pages
- 1613-1618
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2070650287
- Cited by
- 108
- References
- 22
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 6
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Agricultural Research Service
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Social Sciences › Arts and Humanities › Archeology › Forensic Anthropology and Bioarchaeology Studies
- Keywords
- dual-energy X-ray absorptiometry, cross-calibration, bone mineral content, bone mineral density, body composition, fat mass, lean body mass, children, adults, conversion equations
- MeSH terms
- Adult, Body Composition, Bone and Bones, Calibration, Child, Child, Preschool, Humans, Middle Aged, Minerals, Absorptiometry, Photon
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