The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography
Open accessAbstract
We report the first observations of the three-dimensional morphology of cone photoreceptors in the living human retina. Images were acquired with a high-speed adaptive optics (AO) spectral-domain optical coherence tomography (SD-OCT) camera. The AO system consisted of a Shack-Hartmann wavefront sensor and bimorph mirror (AOptix) that measured and corrected the ocular and system aberrations at a closed-loop rate of 12 Hz. The bimorph mirror was positioned between the XY mechanical scanners and the subject's eye. The SD-OCT system consisted of a superluminescent diode and a 512 pixel line scan charge-coupled device (CCD) that acquired 75,000 A-scans/s. This rate is more than two times faster than that previously reported. Retinal motion artifacts were minimized by quickly acquiring small volume images of the retina with and without AO compensation. Camera sensitivity was sufficient to detect reflections from all major retinal layers. The regular distribution of bright spots observed within C-scans at the inner segment / outer segment (IS/OS) junctions and at the posterior tips of the OS were found to be highly correlated with one another and with the expected cone spacing. No correlation was found between the posterior tips of the OS and the other retinal layers examined, including the retinal pigment epithelium.
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Cites
Pigment epithelial ensheathment and phagocytosis of extrafoveal cones in human retina
Steinberg, R. H., Wood, I., & Hogan, M. J. (1977) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1977.0028 · Cited by 131
Cited by
State-of-the-art retinal optical coherence tomography
DREXLER, W., & FUJIMOTO, J. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.07.005 · Cited by 906
Potsaid, B., Gorczynska, I., Srinivasan, V. J., Chen, Y., Jiang, J., Cable, A., & Fujimoto, J. G. (2008) · Optics Express · doi:10.1364/oe.16.015149 · Cited by 372
Optical Coherence Tomography: History, Current Status, and Laboratory Work
Gabriele, M. L., Wollstein, G., Ishikawa, H., Kagemann, L., Xu, J., Folio, L. S., & Schuman, J. S. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6312 · Cited by 310
Polarization sensitive optical coherence tomography in the human eye
Pircher, M., Hitzenberger, C. K., & Schmidt-Erfurth, U. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.06.003 · Cited by 288
Srinivasan, V. J., Monson, B. K., Wojtkowski, M., Bilonick, R. A., Gorczynska, I., Chen, R., Duker, J. S., Schuman, J. S., & Fujimoto, J. G. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0838 · Cited by 277
Metadata
- Authors
- Zhang, Y., Cense, B., Rha, J., Jonnal, R. S., Gao, W., Zawadzki, R. J., Werner, J. S., Jones, S., Olivier, S., & Miller, D. T.
- Venue
- Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2006-05-15
- Volume
- 14
- Issue
- 10
- Pages
- 4380
- ISSN
- 1094-4087 (ISSN-L)
- OpenAlex
- W2056096048
- Cited by
- 220
- References
- 1
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, Y., Cense, B., Rha, J., Jonnal, R. S., Gao, W., Zawadzki, R. J., Werner, J. S., Jones, S., Olivier, S., & Miller, D. T. (2006). High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography. Optics Express. https://doi.org/10.1364/oe.14.004380
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