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Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography
Open accessAbstract
We present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light. Two different segmentation algorithms are presented and discussed: a simpler algorithm based on retardation data, and a more sophisticated algorithm based on local variations of the polarization state calculated from averaged Stokes vector elements. By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes.
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Citations
Cited by
Optical coherence tomography (OCT): principle and technical realization
Aumann, S., Donner, S., Fischer, J., & Müller, F. (2019) · High Resolution Imaging in Microscopy and Ophthalmology · doi:10.1007/978-3-030-16638-0_3 · Cited by 449
Optical Coherence Tomography: History, Current Status, and Laboratory Work
Gabriele, M. L., Wollstein, G., Ishikawa, H., Kagemann, L., Xu, J., Folio, L. S., & Schuman, J. S. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6312 · Cited by 310
Polarization sensitive optical coherence tomography in the human eye
Pircher, M., Hitzenberger, C. K., & Schmidt-Erfurth, U. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.06.003 · Cited by 288
Self-citationOptical coherence tomography – development, principles, applications
Fercher, A. F. (2010) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2009.11.002 · Cited by 259
Baumann, B., Baumann, S. O., Konegger, T., Pircher, M., Götzinger, E., Schlanitz, F., Schütze, C., Sattmann, H., Litschauer, M., Schmidt-Erfurth, U., et al. (2012) · Biomedical Optics Express · doi:10.1364/boe.3.001670 · Cited by 163
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Metadata
- Authors
- Götzinger, E., Pircher, M., Geitzenauer, W., Ahlers, C., Baumann, B., Michels, S., Schmidt-Erfurth, U., & Hitzenberger, C. K.
- Venue
- Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2008-09-30
- Volume
- 16
- Issue
- 21
- Pages
- 16410
- ISSN
- 1094-4087 (ISSN-L)
- OpenAlex
- W2062176231
- Cited by
- 294
- References
- 0
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Götzinger, E., Pircher, M., Geitzenauer, W., Ahlers, C., Baumann, B., Michels, S., Schmidt-Erfurth, U., & Hitzenberger, C. K. (2008). Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. Optics Express. https://doi.org/10.1364/oe.16.016410
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