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Shift of whispering-gallery modes in microspheres by protein adsorption
Abstract
Biosensors based on the shift of whispering-gallery modes in microspheres accompanying protein adsorption are described by use of a perturbation theory. For random spatial adsorption, theory predicts that the shift should be inversely proportional to microsphere radius R and proportional to protein surface density and excess polarizability. Measurements are found to be consistent with the theory, and the correspondence enables the average surface area occupied by a single protein to be estimated. These results are consistent with crystallographic data for bovine serum albumin. The theoretical shift for adsorption of a single protein is found to be extremely sensitive to the target region, with adsorption in the most sensitive region varying as 1/R(5/2). Specific parameters for single protein or virus particle detection are predicted.
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Citations
Cited by
Zijlstra, P., Paulo, P. M. R., & Orrit, M. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.51 · Cited by 788
Iqbal, M., Gleeson, M. A., Spaugh, B., Tybor, F., Gunn, W. G., Hochberg, M., Baehr-Jones, T., Bailey, R. C., & Gunn, L. C. (2010) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2009.2032510 · Cited by 551
Sparse Regularization via Convex Analysis
Selesnick, I. (2017) · IEEE Transactions on Signal Processing · doi:10.1109/tsp.2017.2711501 · Cited by 429
Optical ring resonators for biochemical and chemical sensing
Sun, Y., & Fan, X. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4237-z · Cited by 355
Metadata
- Authors
- Arnold, S., Khoshsima, M., Teraoka, I., Holler, S., & Vollmer, F.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2003-02-15
- Volume
- 28
- Issue
- 4
- Pages
- 272
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2166250628
- Cited by
- 736
- References
- 0
- FWCI
- 22.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arnold, S., Khoshsima, M., Teraoka, I., Holler, S., & Vollmer, F. (2003). Shift of whispering-gallery modes in microspheres by protein adsorption. Optics Letters. https://doi.org/10.1364/ol.28.000272
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