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Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective
Abstract
We present a miniature, flexible two-photon microscope consisting of a fused coherent optical fiber bundle with 30,000 cores and a gradient-index lens objective. The laser focus of a standard two-photon laser-scanning microscope was scanned over the entrance surface of the fiber bundle, resulting in sequential coupling into individual cores. Fluorescent light was detected through the fiber bundle. Micrometer-sized fluorescent beads and pollen grains were readily resolved. In addition, fluorescently labeled blood vessels were imaged through the fiber bundle in rat brain in vivo.
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Cited by
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Flusberg, B. A., Cocker, E. D., Piyawattanametha, W., Jung, J. C., Cheung, E. L. M., & Schnitzer, M. J. (2005) · Nature Methods · doi:10.1038/nmeth820 · Cited by 732
In vivo imaging of neural activity
Yang, W., & Yuste, R. (2017) · Nature Methods · doi:10.1038/nmeth.4230 · Cited by 406
In vivo brain imaging using a portable 39?gram two-photon fluorescence microendoscope
Flusberg, B. A., Jung, J. C., Cocker, E. D., Anderson, E. P., & Schnitzer, M. J. (2005) · Optics Letters · doi:10.1364/ol.30.002272 · Cited by 260
Tools for Resolving Functional Activity and Connectivity within Intact Neural Circuits
Jennings, J. H., & Stuber, G. D. (2014) · Current Biology · doi:10.1016/j.cub.2013.11.042 · Cited by 54
Metadata
- Authors
- Göbel, W., Kerr, J. N. D., Nimmerjahn, A., & Helmchen, F.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2004-11-01
- Volume
- 29
- Issue
- 21
- Pages
- 2521
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2079393071
- Cited by
- 259
- References
- 0
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Göbel, W., Kerr, J. N. D., Nimmerjahn, A., & Helmchen, F. (2004). Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective. Optics Letters. https://doi.org/10.1364/ol.29.002521
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