Tools for Resolving Functional Activity and Connectivity within Intact Neural Circuits

Ultrasensitive fluorescent proteins for imaging neuronal activity

Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works

Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176 · see citing works

Neurodegenerative Disorders: Parkinson's Disease and Huntington's Disease

Hague, S., Klaffke, S., & Bandmann, O. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860948961_0007 · Cited by 2,767 · see citing works

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606 · see citing works

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works

Structural and molecular interrogation of intact biological systems

Chung, K., Wallace, J., Kim, S.-Y., Kalyanasundaram, S., Andalman, A. S., Davidson, T. J., Mirzabekov, J. J., Zalocusky, K. A., Mattis, J., Denisin, A. K., et al. (2013) · Nature · doi:10.1038/nature12107 · Cited by 2,008 · see citing works

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Tian, L., Hires, S. A., Mao, T., Huber, D., Chiappe, M. E., Chalasani, S. H., Petreanu, L., Akerboom, J., McKinney, S. A., Schreiter, E. R., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1398 · Cited by 1,967 · see citing works

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885 · see citing works

Optogenetics in neural systems

Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881 · see citing works

Optogenetic stimulation of a hippocampal engram activates fear memory recall

Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K. A., & Tonegawa, S. (2012) · Nature · doi:10.1038/nature11028 · Cited by 1,669 · see citing works

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works

Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy

Keller, P., Schmidt, A. D., Wittbrodt, J., & Stelzer, E. H. K. (2008) · Science · doi:10.1126/science.1162493 · Cited by 1,569 · see citing works

Optical Deconstruction of Parkinsonian Neural Circuitry

Gradinaru, V., Mogri, M., Thompson, K. R., Henderson, J. M., & Deisseroth, K. A. (2009) · Science · doi:10.1126/science.1167093 · Cited by 1,527 · see citing works

Whole-brain functional imaging at cellular resolution using light-sheet microscopy

Ahrens, M. B., Orger, M. B., Robson, D. N., Li, J. M., & Keller, P. J. (2013) · Nature Methods · doi:10.1038/nmeth.2434 · Cited by 1,392 · see citing works

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318 · see citing works

Amygdala circuitry mediating reversible and bidirectional control of anxiety

Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289 · see citing works

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266 · see citing works

Concurrent activation of striatal direct and indirect pathways during action initiation

Cui, G., Jun, S. B., Jin, X., Pham, M. D., Vogel, S. S., Lovinger, D. M., & Costa, R. M. (2013) · Nature · doi:10.1038/nature11846 · Cited by 1,245 · see citing works

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Akerboom, J., Chen, T., Wardill, T. J., Tian, L., Marvin, J. S., Mutlu, S., Calderón, N. C., Esposti, F., Borghuis, B. G., Sun, X. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2601-12.2012 · Cited by 1,226 · see citing works

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

Watabe‐Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A., & Uchida, N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.017 · Cited by 1,221 · see citing works

High-performance genetically targetable optical neural silencing by light-driven proton pumps

Chow, B. Y., Han, X., Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., et al. (2010) · Nature · doi:10.1038/nature08652 · Cited by 1,188 · see citing works

Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Kim, T.-I., McCall, J. G., Jung, Y. H., Huang, X., Siuda, E. R., Li, Y., Song, J., Song, Y. M., Pao, H. A., Kim, R.-H., et al. (2013) · Science · doi:10.1126/science.1232437 · Cited by 1,174 · see citing works

Long-term dynamics of CA1 hippocampal place codes

Ziv, Y., Burns, L. D., Cocker, E. D., Hamel, E. O., Ghosh, K. K., Kitch, L. J., Gamal, A. E., & Schnitzer, M. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3329 · Cited by 1,155 · see citing works

Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain

Hama, H., Kurokawa, H., Kawano, H., Ando, R., Shimogori, T., Noda, H., Fukami, K., Sakaue-Sawano, A., & Miyawaki, A. (2011) · Nature Neuroscience · doi:10.1038/nn.2928 · Cited by 1,147 · see citing works

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

Gradinaru, V., Zhang, F., Ramakrishnan, C., Mattis, J., Prakash, R., Diester, I., Goshen, I., Thompson, K. R., & Deisseroth, K. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.037 · Cited by 999 · see citing works

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 996 · see citing works

Deconstruction of a neural circuit for hunger

Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969 · see citing works

Creating a False Memory in the Hippocampus

Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013) · Science · doi:10.1126/science.1239073 · Cited by 968 · see citing works

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

Ke, M., Fujimoto, S., & Imai, T. (2013) · Nature Neuroscience · doi:10.1038/nn.3447 · Cited by 895 · see citing works

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking

Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878 · see citing works

Functional imaging of hippocampal place cells at cellular resolution during virtual navigation

Dombeck, D. A., Harvey, C. D., Tian, L., Looger, L. L., & Tank, D. W. (2010) · Nature Neuroscience · doi:10.1038/nn.2648 · Cited by 873 · see citing works

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

Mattis, J., Tye, K. M., Ferenczi, E. A., Ramakrishnan, C., O'Shea, D. J., Prakash, R., Gunaydin, L. A., Hyun, M., Fenno, L. E., Gradinaru, V., et al. (2012) · Nature Methods · doi:10.1038/nmeth.1808 · Cited by 780 · see citing works

Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex

Gray, C. M., Maldonado, P., Wilson, M., & McNaughton, B. L. (1995) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00085-2 · Cited by 746 · see citing works

Optogenetic investigation of neural circuits underlying brain disease in animal models

Tye, K. M., & Deisseroth, K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3171 · Cited by 745 · see citing works

Depolarization and calcium entry in squid giant axons

Baker, P. F., Hodgkin, A. L., & Ridgway, E. B. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009641 · Cited by 729 · see citing works

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

Lee, J. H., Durand, R., Gradinaru, V., Zhang, F., Goshen, I., Kim, D., Fenno, L. E., Ramakrishnan, C., & Deisseroth, K. A. (2010) · Nature · doi:10.1038/nature09108 · Cited by 713 · see citing works

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

Akerboom, J., Calderón, N. C., Tian, L., Wabnig, S., Prigge, M., Tolö, J., Gordus, A. G., Orger, M. B., Severi, K. E., Macklin, J. J., et al. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00002 · Cited by 710 · see citing works

Distinct extended amygdala circuits for divergent motivational states

Jennings, J. H., Sparta, D. R., Stamatakis, A. M., Ung, R. L., Pleil, K. E., Kash, T. L., & Stuber, G. D. (2013) · Nature · doi:10.1038/nature12041 · Cited by 704 · cited 5× · see citing works

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

Zhang, F., Gradinaru, V., Adamantidis, A. R., Durand, R., Airan, R. D., de Lecea, L., & Deisseroth, K. (2010) · Nature Protocols · doi:10.1038/nprot.2009.226 · Cited by 692 · see citing works

Retrograde neuronal tracing with a deletion-mutant rabies virus

Wickersham, I. R., Finke, S., Conzelmann, K., & Callaway, E. M. (2006) · Nature Methods · doi:10.1038/nmeth999 · Cited by 686 · see citing works

Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement

Witten, I. B., Steinberg, E. E., Lee, S. Y., Davidson, T. J., Zalocusky, K. A., Brodsky, M., Yizhar, O., Cho, S. L., Gong, S., Ramakrishnan, C., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.028 · Cited by 680 · see citing works

Serial two-photon tomography for automated ex vivo mouse brain imaging

Ragan, T. M., Kadiri, L. R., Venkataraju, K. U., Bahlmann, K., Sutin, J. D. B., Taranda, J., Arganda‐Carreras, I., Kim, Y., Seung, H. S., & Osten, P. (2012) · Nature Methods · doi:10.1038/nmeth.1854 · Cited by 659 · see citing works

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

Atasoy, D., Aponte, Y., Su, H. H., & Sternson, S. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1954-08.2008 · Cited by 614 · see citing works

Cerebral Astrocyte Response to Micromachined Silicon Implants

Turner, J. N., Shain, W. G., Szarowski, D. H., Andersen, M., Martins, S., Isaacson, M. S., & Craighead, H. G. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.6983 · Cited by 593 · see citing works

Correlations of Neuronal and Microvascular Densities in Murine Cortex Revealed by Direct Counting and Colocalization of Nuclei and Vessels

Tsai, P. S., Kaufhold, J. P., Blinder, P., Friedman, B., Drew, P. J., Karten, H. J., Lyden, P. D., & Kleinfeld, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3287-09.2009 · Cited by 575 · see citing works

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2

Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K. A., Tsai, L., & Moore, C. I. (2010) · Nature Protocols · doi:10.1038/nprot.2009.228 · Cited by 542 · see citing works

Multiple dynamic representations in the motor cortex during sensorimotor learning

Huber, D., Gutnisky, D. A., Peron, S., O’Connor, D. H., Wiegert, J. S., Tian, L., Oertner, T. G., Looger, L. L., & Svoboda, K. (2012) · Nature · doi:10.1038/nature11039 · Cited by 540 · see citing works

Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice

Huber, D., Petreanu, L., Ghitani, N., Ranade, S., Hromádka, T., Mainen, Z., & Svoboda, K. (2008) · Nature · doi:10.1038/nature06445 · Cited by 539 · see citing works

Distinct behavioural and network correlates of two interneuron types in prefrontal cortex

Kvitsiani, D., Ranade, S., Hangya, B., Taniguchi, H., Huang, J. Z., & Kepecs, A. (2013) · Nature · doi:10.1038/nature12176 · Cited by 516 · see citing works

In vivo studies of polypyrrole/peptide coated neural probes

Cui, X. T. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00415-5 · Cited by 505 · see citing works

The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding

Jennings, J. H., Rizzi, G., Stamatakis, A. M., Ung, R. L., & Stuber, G. D. (2013) · Science · doi:10.1126/science.1241812 · Cited by 493 · see citing works

Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice

Stanley, S. A., Gagner, J. E., Damanpour, S., Yoshida, M., Dordick, J. S., & Friedman, J. M. (2012) · Science · doi:10.1126/science.1216753 · Cited by 490 · see citing works

Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons

Wall, N. R., De La Parra, M., Callaway, E. M., & Kreitzer, A. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.014 · Cited by 489 · see citing works

Factors influencing the biocompatibility of insertable silicon microshafts in cerebral cortex

Edell, D. J., Toi, V. V., McNeil, V. M., & Clark, L. D. (1992) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.141202 · Cited by 479 · see citing works

Neural Activity in Barrel Cortex Underlying Vibrissa-Based Object Localization in Mice

O’Connor, D. H., Peron, S., Huber, D., & Svoboda, K. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.026 · Cited by 453 · see citing works

Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice

Komiyama, T., Sato, T. R., O’Connor, D. H., Zhang, Y.-X., Huber, D., Hooks, B. M., Gabitto, M., & Svoboda, K. (2010) · Nature · doi:10.1038/nature08897 · Cited by 447 · see citing works

Thinned-skull cranial window technique for long-term imaging of the cortex in live mice

Yang, G., Pan, F., Parkhurst, C. N., Grutzendler, J., & Gan, W. (2010) · Nature Protocols · doi:10.1038/nprot.2009.222 · Cited by 438 · see citing works

Hypothalamic Control of Feeding and Self-Stimulation

Hoebel, B. G., & Teitelbaum, P. (1962) · Science · doi:10.1126/science.135.3501.375 · Cited by 389 · see citing works

Generation of a synthetic memory trace

Garner, A. R., Rowland, D. C., Hwang, S. Y., Baumgaertel, K., Roth, B. L., Kentros, C., & Mayford, M. (2012) · Science · doi:10.1126/science.1214985 · Cited by 387 · see citing works

In Vivo Mammalian Brain Imaging Using One- and Two-Photon Fluorescence Microendoscopy

Jung, J. C., Mehta, A. D., Aksay, E. R. F., Stepnoski, R. A., & Schnitzer, M. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00234.2004 · Cited by 382 · see citing works

Optetrode: a multichannel readout for optogenetic control in freely moving mice

Anikeeva, P., Andalman, A. S., Witten, I. B., Warden, M. R., Goshen, I., Grosenick, L., Gunaydin, L. A., Frank, L. M., & Deisseroth, K. A. (2011) · Nature Neuroscience · doi:10.1038/nn.2992 · Cited by 381 · see citing works

Long-term stability of the place-field activity of single units recorded from the dorsal hippocampus of freely behaving rats

Thompson, L. T., & Best, P. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90555-p · Cited by 370 · see citing works

A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward

Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364 · see citing works

Lateral competition for cortical space by layer-specific horizontal circuits

Adesnik, H., & Scanziani, M. (2010) · Nature · doi:10.1038/nature08935 · Cited by 356 · see citing works

PINP: A New Method of Tagging Neuronal Populations for Identification during In Vivo Electrophysiological Recording

Lima, S. Q., Hromádka, T., Znamenskiy, P., & Zador, A. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006099 · Cited by 356 · see citing works

Determination of antidromic excitation by the collision test: Problems of interpretation

Fuller, J. H., & Schlag, J. D. (1976) · Brain Research · doi:10.1016/0006-8993(76)90284-5 · Cited by 341 · see citing works

Remote Control of Neuronal Signaling

Rogan, S. C., & Roth, B. L. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003020 · Cited by 339 · see citing works

Identical "Feeding" and "Rewarding" Systems in the Lateral Hypothalamus of Rats

Margules, D. L., & Olds, J. (1962) · Science · doi:10.1126/science.135.3501.374 · Cited by 328 · see citing works

Rabies as a transneuronal tracer of circuits in the central nervous system

Kelly, R. M., & Strick, P. L. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00296-x · Cited by 319 · see citing works

New Rabies Virus Variants for Monitoring and Manipulating Activity and Gene Expression in Defined Neural Circuits

Osakada, F., Mori, T., Cetin, A. H., Marshel, J. H., Virgen, B., & Callaway, E. M. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.005 · Cited by 314 · see citing works

Piecing together the Puzzle of Basal Forebrain Anatomy

Heimer, L., & Alheid, G. F. (1991) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4757-0145-6_1 · Cited by 310 · cited 1× · see citing works

Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors

Nathanson, J. L., Yanagawa, Y., Obata, K., & Callaway, E. M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.032 · Cited by 305 · see citing works

Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design

Akerboom, J., Rivera, J. D. V., Rodríguez‐Guilbe, M. M., Malavé, E. C. A., Hernández, H. H., Tian, L., Hires, S. A., Marvin, J. S., Looger, L. L., & Schreiter, E. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807657200 · Cited by 286 · see citing works

Cortical calcium waves in resting newborn mice

Adelsberger, H., Garaschuk, O., & Konnerth, A. (2005) · Nature Neuroscience · doi:10.1038/nn1502 · Cited by 280 · see citing works

Imaging Calcium Concentration Dynamics in Small Neuronal Compartments

Yasuda, R., Nimchinsky, E. A., Scheuß, V., Pologruto, T. A., Oertner, T. G., Sabatini, B. L., & Svoboda, K. (2004) · Science s STKE · doi:10.1126/stke.2192004pl5 · Cited by 278 · see citing works

Controlling signaling with a specifically designed Gi-coupled receptor.

Coward, P., Wada, H., Falk, M., Chan, S. D., Meng, F., Akil, H., & Conklin, B. R. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.1.352 · Cited by 262 · see citing works

Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective

Göbel, W., Kerr, J. N. D., Nimmerjahn, A., & Helmchen, F. (2004) · Optics Letters · doi:10.1364/ol.29.002521 · Cited by 261 · see citing works

Using immediate-early genes to map hippocampal subregional functionsPreprint

Kubík, Š., Miyashita, T., & Guzowski, J. F. (2007) · Learning & Memory · doi:10.1101/lm.698107 · Cited by 257 · see citing works

Transneuronal circuit tracing with neurotropic viruses

Callaway, E. M. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.03.007 · Cited by 252 · see citing works

Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity

Zhang, S., Ye, J., Miao, C., Tsao, A., Cerniauskas, I., Ledergerber, D., Moser, M., & Moser, E. I. (2013) · Science · doi:10.1126/science.1232627 · Cited by 251 · see citing works

Pharmacogenetic Modulation of Orexin Neurons Alters Sleep/Wakefulness States in Mice

Sasaki, K., Suzuki, M., Mieda, M., Tsujino, N., Roth, B. L., & Sakurai, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020360 · Cited by 248 · see citing works

Adeno-associated virus vectors for gene therapy: more pros than cons?

Monahan, P. E., & Samulski, R. J. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01810-4 · Cited by 228 · see citing works

Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits

Zorzos, A. N., Scholvin, J., Boyden, E. S., & Fonstad, C. G. (2012) · Optics Letters · doi:10.1364/ol.37.004841 · Cited by 185 · see citing works

Retrograde Axon Transport of Herpes Simplex Virus and Pseudorabies Virus: a Live-Cell Comparative Analysis

Antinone, S. E., & Smith, G. A. (2009) · Journal of Virology · doi:10.1128/jvi.02029-09 · Cited by 182 · see citing works

Endocytic and exocytic pathways of the neuronal secretory process and trans synaptic transfer of wheat germ agglutinin‐horseradish peroxidase in vivo

Broadwell, R. D., & Balin, B. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902420410 · Cited by 180 · see citing works

Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons

Saunders, A. B., Johnson, C. A., & Sabatini, B. L. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00047 · Cited by 165 · see citing works

Septo-hippocampal GABAergic signaling across multiple modalities in awake mice

Kaifosh, P., Lovett-Barron, M., Turi, G. F., Reardon, T. R., & Losonczy, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3482 · Cited by 155 · see citing works

"Copulation-Reward Site" in the Posterior Hypothalamus

Caggiula, A. R., & Hoebel, B. G. (1966) · Science · doi:10.1126/science.153.3741.1284 · Cited by 114 · see citing works

Multiple Circuits Relaying Primate Parallel Visual Pathways to the Middle Temporal Area

Nassi, J. J., & Callaway, E. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4044-06.2006 · Cited by 100 · see citing works

Cellular Resolution Functional Imaging in Behaving Rats Using Voluntary Head Restraint

Scott, B. B., Brody, C. D., & Tank, D. W. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.002 · Cited by 95 · see citing works

The Functional Properties of Barrel Cortex Neurons Projecting to the Primary Motor Cortex

Sato, T. R., & Svoboda, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3774-09.2010 · Cited by 94 · see citing works

Transneuronal transport of lectins

Fabian, R. H., & Coulter, J. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)91187-4 · Cited by 76 · see citing works

A Role for Myosin VI in the Localization of Axonal Proteins

Lewis, T. L., Mao, T., & Arnold, D. B. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001021 · Cited by 71 · see citing works

Anterograde neuronal circuit tracing using a genetically modified herpes simplex virus expressing EGFP

McGovern, A. E., Davis-Poynter, N. J., Rakoczy, J., Phipps, S., Simmons, D. G., & Mazzone, S. B. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.05.035 · Cited by 67 · see citing works

Herpes simplex virus as a transneuronal tracer

Norgren, R. B., & Lehman, M. N. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00008-6 · Cited by 57 · see citing works

Dissecting local circuits in vivo: Integrated optogenetic and electrophysiology approaches for exploring inhibitory regulation of cortical activity

Cardin, J. A. (2011) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2011.09.005 · Cited by 55 · see citing works

Visualizing selective neural pathways with WGA transgene: combination of neuroanatomy with gene technology

Yoshihara, Y. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00130-x · Cited by 51 · see citing works

Genetic control of active neural circuits

Reijmers, L. G. J. E. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.027.2009 · Cited by 50 · see citing works

Transformation of odor selectivity from projection neurons to single mushroom body neurons mapped with dual-color calcium imaging

Li, H., Li, Y., Lei, Z., Wang, K., & Guo, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305857110 · Cited by 50 · see citing works

Optogenetic interrogation of neural circuits: technology for probing mammalian brain

Gradinaru, V., Adamantidis, A., Durand, R., Airan, R. D., de Lecea, L., & Deisseroth, K. A. (2010) · Cited by 39 · see citing works

Spread of vesicular stomatitis virus along the visual pathways after retinal infection in the mouse

Lundh, B. (1990) · Acta Neuropathologica · doi:10.1007/bf00308715 · Cited by 35 · see citing works

Timing of Impulses From the Central Amygdala and Bed Nucleus of the Stria Terminalis to the Brain Stem

Nagy, F. Z., & Paré, D. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90936.2008 · Cited by 27 · see citing works

Neuronal circuits for fear and anxiety

Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786 · see citing works

Glial responses to implanted electrodes in the brain

Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642 · see citing works

Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors

Jennings, J. H., Ung, R. L., Resendez, S. L., Stamatakis, A. M., Taylor, J. G., Huang, J. H., Veleta, K., Kantak, P. A., Aita, M., Shilling-Scrivo, K. V., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.026 · Cited by 550 · see citing works

Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic mammalian behavior with head-mounted microscopes and chronically implanted lenses

Resendez, S. L., Jennings, J. H., Ung, R. L., Namboodiri, V. M. K., Zhou, Z. C., Otis, J. M., Nomura, H., McHenry, J. A., Kosyk, O., & Stuber, G. D. (2016) · Nature Protocols · doi:10.1038/nprot.2016.021 · Cited by 331 · see citing works

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.

Deussing, J., & Chen, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2017 · Cited by 234 · see citing works

Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons

Tian, J., Huang, R., Cohen, J. Y., Osakada, F., Kobak, D., Machens, C. K., Callaway, E. M., Uchida, N., & Watabe-Uchida, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.018 · Cited by 224 · see citing works

The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains

Chang, E. H., Argyelan, M., Aggarwal, M., Chandon, T.-S. S., Karlsgodt, K. H., Mori, S., & Malhotra, A. K. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.068 · Cited by 186 · see citing works

Habenula Lesions Reveal that Multiple Mechanisms Underlie Dopamine Prediction Errors

Tian, J., & Uchida, N. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.028 · Cited by 165 · see citing works

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

Chen, X., Choo, H., Huang, X., Yang, X., Stone, O. J., Roth, B. L., & Jin, J. J. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500325v · Cited by 153 · see citing works

A soft, transparent, freely accessible cranial window for chronic imaging and electrophysiology

Heo, C., Park, H., Kim, Y., Baeg, E., Kim, Y. H., Kim, S., & Suh, M. (2016) · Scientific Reports · doi:10.1038/srep27818 · Cited by 143 · see citing works

DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics

Day, J. J., Kennedy, A. J., & Sweatt, J. D. (2015) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124527 · Cited by 78 · see citing works

Heterogeneity in the Paraventricular Thalamus: The Traffic Light of Motivated Behaviors

McGinty, J. F., & Otis, J. M. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.590528 · Cited by 76 · see citing works

Regenerative Electrode Interfaces for Neural Prostheses.

Thompson, C. H., Zoratti, M. J., Langhals, N. B., & Purcell, E. K. (2016) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2015.0279 · Cited by 67 · see citing works

Probing Deep Brain Circuitry: New Advances in in Vivo Calcium Measurement Strategies

Girven, K. S., & Sparta, D. R. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00307 · Cited by 61 · see citing works

In vivo Calcium Imaging to Illuminate Neurocircuit Activity Dynamics Underlying Naturalistic Behavior

Resendez, S. L., & Stuber, G. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.206 · Cited by 61 · see citing works

A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior

Tashima, R., Koga, K., Yoshikawa, Y., Sekine, M., Watanabe, M., Tozaki-Saitoh, H., Furue, H., Yasaka, T., & Tsuda, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021220118 · Cited by 54 · see citing works

Head-mounted microendoscopic calcium imaging in dorsal premotor cortex of behaving rhesus macaque

Bollimunta, A., Santacruz, S. R., Eaton, R. W., Xu, P. S., Morrison, J. H., Moxon, K. A., Carmena, J. M., & Nassi, J. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109239 · Cited by 47 · see citing works

Contributions of nucleus accumbens dopamine to cognitive flexibility

Radke, A. K., Kocharian, A., Covey, D. P., Lovinger, D. M., Cheer, J. F., Mateo, Y., & Holmes, A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14152 · Cited by 42 · see citing works

Organization of dopamine and serotonin system: Anatomical and functional mapping of monosynaptic inputs using rabies virus

Ogawa, S. K., & Watabe‐Uchida, M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.001 · Cited by 40 · see citing works

Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction

Saunders, B. T., Richard, J. M., & Janak, P. H. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0210 · Cited by 38 · see citing works

Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus

Aqrabawi, A. J., & Kim, J. C. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00012 · Cited by 32 · see citing works

Hippocampus and Prefrontal Cortex Predict Distinct Timescales of Activation in the Human Ventral Tegmental Area

Murty, V. P., Ballard, I. C., & Adcock, R. A. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw005 · Cited by 28 · see citing works

Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors

Nonaka, M., Kim, R., Sharry, S., Matsushima, A., Takemoto‐Kimura, S., & Bito, H. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.010 · Cited by 29 · see citing works

Stereotypical patterns of epileptiform calcium signal in hippocampal CA1, CA3, dentate gyrus and entorhinal cortex in freely moving mice

Zhang, X., Qiao, Z., Liu, N., Gao, L., Wei, L., Liu, A., Ma, Z., Wang, F., Hou, S., Li, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41241-x · Cited by 28 · see citing works

New approaches to manipulating the epigenome

Day, J. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/jday · Cited by 27 · see citing works

Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains

Ohta, Y., Guinto, M. C., Tokuda, T., Kawahara, M., Haruta, M., Takehara, H., Tashiro, H., Sasagawa, K., Onoe, H., Yamaguchi, R., et al. (2021) · IEEE Access · doi:10.1109/access.2021.3111666 · Cited by 27 · see citing works

Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence

Garcia‐Rivas, V., & Deroche‐Gamonet, V. (2018) · Addiction Biology · doi:10.1111/adb.12607 · Cited by 25 · see citing works

An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping

Hamada, S., Nagase, M., Yoshizawa, T., Hagiwara, A., Isomura, Y., Watabe, A. M., & Ohtsuka, T. (2021) · Communications Biology · doi:10.1038/s42003-021-01977-7 · Cited by 23 · see citing works

Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope

Wu, J., Chen, Y., Veeraraghavan, A., Seidemann, E., & Robinson, J. T. (2024) · Nature Communications · doi:10.1038/s41467-024-45417-6 · Cited by 22 · see citing works

Probing striatal microcircuitry to understand the functional role of cholinergic interneurons

Girasole, A. E., & Nelson, A. (2015) · Movement Disorders · doi:10.1002/mds.26340 · Cited by 23 · see citing works

Optical Approaches for Interrogating Neural Circuits Controlling Hormone Secretion

Han, S. Y., Clarkson, J., Piet, R., & Herbison, A. E. (2018) · Endocrinology · doi:10.1210/en.2018-00594 · Cited by 16 · see citing works

Levels of Cocaine- and Amphetamine-Regulated Transcript in Vagal Afferents in the Mouse Are Unaltered in Response to Metabolic Challenges

Yuan, X., Huang, Y., Shah, S., Wu, H., & Gautron, L. (2016) · eNeuro · doi:10.1523/eneuro.0174-16.2016 · Cited by 14 · see citing works

Genetic Modulation at the Neural Microelectrode Interface: Methods and Applications

Winter, B. M., Daniels, S. R., Salatino, J. W., & Purcell, E. K. (2018) · Micromachines · doi:10.3390/mi9100476 · Cited by 14 · see citing works

Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK

Bellocchio, L., Ruiz-Calvo, A., Chiarlone, A., Cabanas, M., Resel, E., Cazalets, J., Blázquez, C., Cho, Y. H., Galve‐Roperh, I., & Guzmán, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1192-16.2016 · Cited by 13 · see citing works

Systems genetics of behavior: a prelude

Mulligan, M. K., & Williams, R. W. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.01.014 · Cited by 10 · see citing works

Neural Circuits for Fear Relapse

Goode, T. D., Jin, J., & Maren, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813693-5.00010-1 · Cited by 9 · see citing works

Automated and parallelized spike collision tests to identify spike signal projections

Mitani, K., Kawabata, M., Isomura, Y., & Sakai, Y. (2022) · iScience · doi:10.1016/j.isci.2022.105071 · Cited by 7 · see citing works

Operationalizing Cognitive Science and Technologies' Research and Development; the "Brain and Cognition Study Group (BCSG)" Initiative from Shiraz, Iran.

Ashjazadeh, N., Boostani, R., Ekhtiari, H., Emamghoreishi, M., Farrokhi, M. R., Ghanizadeh, A. J., Hatam, G., Hadianfard, H., Lotfi, M., Mortazavi, S. M. J., et al. (2014) · Europe PMC (PubMed Central) · Cited by 5 · see citing works

New Pioneers of Optogenetics in Neuroscience

Somuncu, O., Berns, H. M., & Sanchez, J. G. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2019_473 · Cited by 5 · see citing works

Measuring G protein-coupled receptor signalling in the brain with resonance energy transfer based biosensors

Jones-Tabah, J., Clarke, P. B. S., & Hébert, T. E. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.10.008 · Cited by 3 · see citing works

“There’s plenty of room at the bottom”: deep brain imaging with holographic endo-microscopy

Uhlířová, H., Stibůrek, M., Pikálek, T., Gomes, A. D., Turtaev, S., Kolbábková, P., & Čižmár, T. (2024) · Neurophotonics · doi:10.1117/1.nph.11.s1.s11504 · Cited by 3 · see citing works

Transcriptional Regulation of Memory Formation

Chatterjee, S., & Abel, T. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21107-3 · Cited by 2 · see citing works

Multimodal Functional Analysis Platform: 1. Ultrathin Fluorescence Endoscope Imaging System Enables Flexible Functional Brain Imaging

Osanai, M., Miwa, H., Tamura, A., Kikuta, S., Iguchi, Y., Yanagawa, Y., Kobayashi, K., Katayama, N., Tanaka, T., & Mushiake, H. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-8763-4_31 · Cited by 2 · see citing works

Transcriptional and epigenetic regulation of memory storage

Abel, T. G., Basu, B., & Chatterjee, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00076-6 · Cited by 1 · see citing works

Automated Axon Segmentation from Highly Noisy Microscopic Videos

Bowler, J. C., Feris, R. S., Cao, L., Wang, J., & Zhou, M. (2015) · IEEE Winter Conference on Applications of Computer Vision · doi:10.1109/wacv.2015.126 · Cited by 1 · see citing works

Visualizing and Measuring Neural Dynamics

Carter, M. E., Essner, R. A., Goldstein, N., & Iyer, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818646-6.00005-1 · Cited by 1 · see citing works

OPERATIONALIZING COGNITIVE SCIENCE AND TECHNOLOGIES’ RESEARCH AND DEVELOPMENT; THE “BRAIN AND COGNITION STUDY GROUP (BCSG)” INITIATIVE FROM SHIRAZ, IRAN (LETTER TO EDITOR)

Ashjazadeh, N., Reza, B., Ekhtiari, H., Masoumeh, E. G., Majidreza, F., Ghanizadeh, A. J., Gholamreza, H., Hadianfard, H., Lotfi, M., Mortazavi, S. M. J., et al. (2014)

Neural Circuit Mechanisms Underlying Dopamine Reward Prediction Errors

Tian, J. (2016) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Neural Circuits Underlying the Pathophysiology of Major Depression

Amidfar, M., & Kim, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_3

References

(2016) · Elsevier eBooks · doi:10.1016/b978-0-12-407908-3.10000-7

Nodes and Edges

(2016) · Elsevier eBooks · doi:10.1016/b978-0-12-407908-3.00002-9 · Cited by 1 · see citing works

Interaction between dorsal horn neuron subsets operated by a neuropeptide Y and prodynorphin promoter and its contribution to Aβ fiber–induced allodynia–like behavior in rats

Sueto, D., Ishibashi, T., Eriko, I., Tashima, R., Yoshikawa, Y., Yamaura, K., & Tsuda, M. (2024) · PAIN RESEARCH · doi:10.11154/pain.39.40

Effect of Retinal on Dictyostelium Cells During Development

Akiyama, K., Tsuchihashi, S., & Morimoto, Y. V. (2025) · Genes to Cells · doi:10.1111/gtc.70037

Projection - specific connectivity mapping of serotonergic neurons in the dorsal raphe

Bergenstråhle, J. (2014)

NEURAL CIRCUIT DYNAMICS AND FUNCTION OF COMPLEX BEHAVIORAL STATES

Jennings, J. H. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/qe65-hy07

Form Meets Function in the Brain: Observing the Activity and Structure of Specific Neural Connections

Deisseroth, K. A. (2016) · Research and perspectives in neurosciences · doi:10.1007/978-3-319-27777-6_3 · Cited by 6 · see citing works

Molecular tools to capture active neural circuits

Onishi, T., Hirose, K., & Sakaba, T. (2024) · Frontiers in Neural Circuits · doi:10.3389/fncir.2024.1449459 · Cited by 5 · see citing works

The promise and perils of causal circuit manipulations

Wolff, S. B. E., & Ölveczky, B. P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.01.004 · Cited by 114 · see citing works

Correlating behavior and neural activity at high resolution

Vogt, N. (2018) · Nature Methods · doi:10.1038/s41592-018-0057-4 · Cited by 4 · see citing works