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Gold nanoshell bioconjugates for molecular imaging in living cells
Abstract
Advances in scattering-based optical imaging technologies offer a new approach to noninvasive point-of-care detection, diagnosis, and monitoring of cancer. Emerging photonics technologies provide a cost-effective means to image tissue in vivo with high resolution in real time. Advancing the clinical potential of these imaging strategies requires the development of optical contrast agents targeted to specific molecular signatures of disease. We describe the use of a novel class of contrast agents based on nanoshell bioconjugates for molecular imaging in living cells. Nanoshells offer significant advantages over conventional imaging probes including continuous and broad wavelength tunability, far greater scattering and absorption coefficients, increased chemical stability, and improved biocompatibility. We show that nanoshell bioconjugates can be used to effectively target and image human epidermal growth factor receptor 2 (HER2), a clinically relevant biomarker, in live human breast carcinoma cells.
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Cites
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
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Jazayeri, M. H., Amani, H., Pourfatollah, A. A., Pazoki-Toroudi, H., & Sedighimoghaddam, B. (2016) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2016.04.002 · Cited by 528
Biomedical Applications of Plasmon Resonant Metal Nanoparticles
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Lee, S. E., Liu, G. L., Kim, F., & Lee, L. P. (2009) · Nano Letters · doi:10.1021/nl802689k · Cited by 224
Diagaradjane, P., Shetty, A., Wang, J. C., Elliott, A. M., Schwartz, J., Shentu, S., Park, H. C., Deorukhkar, A., Stafford, R. J., Cho, S. H., et al. (2008) · Nano Letters · doi:10.1021/nl080496z · Cited by 215
Metadata
- Authors
- Loo, C., Hirsch, L., Lee, M.-H., Chang, E., West, J., Halas, N., & Drezek, R.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2005-05-01
- Volume
- 30
- Issue
- 9
- Pages
- 1012
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2027507187
- Cited by
- 305
- References
- 1
- FWCI
- 17.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loo, C., Hirsch, L., Lee, M.-H., Chang, E., West, J., Halas, N., & Drezek, R. (2005). Gold nanoshell bioconjugates for molecular imaging in living cells. Optics Letters. https://doi.org/10.1364/ol.30.001012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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