The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Integrated optics ring-resonator sensors for protein detection
Abstract
Using an integrated optics ring-resonator biosensor, we have demonstrated the detection of protein in low concentrations. We detected 0.3 nM of avidin in a buffered saline solution; the calculated detection limit is 0.1 nM (6.8 ng/ml) for avidin, which compares favorably with those of other optical protein detection techniques. Further improvement is possible. Our ring resonator utilizes Si(x)N(y)/SiO2 waveguides, which, owing to evanescent field interaction, change the effective refractive index when target molecules are immobilized on their surfaces. The selectivity of the sensor depends on the biotin surface coating, which causes the specific binding and immobilization of avidin.
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Citations
Cites
Protein detection by optical shift of a resonant microcavity
Vollmer, F., Braun, D., Libchaber, A., Khoshsima, M., Teraoka, I., & Arnold, S. (2002) · Applied Physics Letters · doi:10.1063/1.1482797 · Cited by 903
Polymer micro-ring filters and modulators
Rabiei, P., Steier, W. H., Zhang, C., & Dalton, L. R. (2002) · Journal of Lightwave Technology · doi:10.1109/jlt.2002.803058 · Cited by 562
Karlsson, R., & Stahlberg, R. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1350 · Cited by 280
Sensor based on an integrated optical microcavity
Krioukov, E., Klunder, D. J. W., Driessen, A., Greve, J., & Otto, C. (2002) · Optics Letters · doi:10.1364/ol.27.000512 · Cited by 231
Cited by
On the performance quantification of resonant refractive index sensors
White, I. M., & Fan, X. (2008) · Optics Express · doi:10.1364/oe.16.001020 · Cited by 1,105
Integrated optofluidics: A new river of light
Monat, C., Domachuk, P., & Eggleton, B. J. (2007) · Nature Photonics · doi:10.1038/nphoton.2006.96 · Cited by 955
Iqbal, M., Gleeson, M. A., Spaugh, B., Tybor, F., Gunn, W. G., Hochberg, M., Baehr-Jones, T., Bailey, R. C., & Gunn, L. C. (2010) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2009.2032510 · Cited by 551
Label-free biological and chemical sensors
Hunt, H. K., & Armani, A. M. (2010) · Nanoscale · doi:10.1039/c0nr00201a · Cited by 371
Jiang, X., Qavi, A. J., Huang, S. H., & Yang, L. (2020) · Matter · doi:10.1016/j.matt.2020.07.008 · Cited by 353
Metadata
- Authors
- Ksendzov, A., & Lin, Y.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2005-12-15
- Volume
- 30
- Issue
- 24
- Pages
- 3344
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2027253574
- Cited by
- 253
- References
- 4
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ksendzov, A., & Lin, Y. (2005). Integrated optics ring-resonator sensors for protein detection. Optics Letters. https://doi.org/10.1364/ol.30.003344
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
