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Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries
Open accessAbstract
Capillaries, the smallest blood vessels, are the distal end of the vasculature where oxygen and nutrients are exchanged between blood and tissue. Hence, noninvasive imaging of capillaries and function in vivo has long been desired as a window to studying fundamental physiology, such as neurovascular coupling. Existing imaging modalities cannot provide the required sensitivity and spatial resolution. We present in vivo imaging of the microvasculature including single capillaries in mice using optical-resolution photoacoustic microscopy (OR-PAM) developed in our laboratory. OR-PAM provides a lateral resolution of 5 microm and an imaging depth >0.7 mm.
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Citations
Cited by
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Self-citationGoing deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
Yao, J., & Wang, L. V. (2013) · Laser & Photonics Reviews · doi:10.1002/lpor.201200060 · Cited by 616
Self-citationProspects of photoacoustic tomography
Wang, L. V. (2008) · Medical Physics · doi:10.1118/1.3013698 · Cited by 561
Self-citationIn Vivo Molecular Photoacoustic Tomography of Melanomas Targeted by Bioconjugated Gold Nanocages
Kim, C., Cho, E. C., Chen, J., Song, K. H., Au, L., Favazza, C., Zhang, Q., Cobley, C. M., Gao, F., Xia, Y., et al. (2010) · ACS Nano · doi:10.1021/nn100736c · Cited by 462
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Metadata
- Authors
- Maslov, K., Zhang, H. F., Hu, S., & Wang, L. V.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 2008-04-23
- Volume
- 33
- Issue
- 9
- Pages
- 929
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W2024849456
- Cited by
- 763
- References
- 0
- FWCI
- 29.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Maslov, K., Zhang, H. F., Hu, S., & Wang, L. V. (2008). Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries. Optics Letters. https://doi.org/10.1364/ol.33.000929
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