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Magnetomotive contrast for in vivo optical coherence tomography
Open accessAbstract
Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 microg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology.
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Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971
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Interferometric synthetic aperture microscopy
Ralston, T. S., Marks, D. L., Scott Carney, P., & Boppart, S. A. (2007) · Nature Physics · doi:10.1038/nphys514 · Cited by 408
Self-citationNanoparticles: A New Approach to Upgrade Cancer Diagnosis and Treatment
Yu, Z., Gao, L., Chen, K., Zhang, W., Zhang, Q., Li, Q., & Hu, K. (2021) · Nanoscale Research Letters · doi:10.1186/s11671-021-03489-z · Cited by 138
Metadata
- Authors
- Oldenburg, A. L., Toublan, F. J.-J., Suslick, K. S., Wei, A., & Boppart, S. A.
- Venue
- Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2005
- Volume
- 13
- Issue
- 17
- Pages
- 6597
- ISSN
- 1094-4087 (ISSN-L)
- OpenAlex
- W2079786622
- Cited by
- 166
- References
- 1
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Oldenburg, A. L., Toublan, F. J.-J., Suslick, K. S., Wei, A., & Boppart, S. A. (2005). Magnetomotive contrast for in vivo optical coherence tomography. Optics Express. https://doi.org/10.1364/opex.13.006597
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