The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Biglycan: A Multivalent Proteoglycan Providing Structure and Signals
Open accessAbstract
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule. Proteolytically released from the ECM, biglycan acts as a danger signal signifying tissue stress or injury. As a ligand of innate immunity receptors and activator of the inflammasome, biglycan stimulates multifunctional proinflammatory signaling linking the innate to the adaptive immune response. By clustering several types of receptors on the cell surface and orchestrating their downstream signaling events, biglycan is capable to autonomously trigger sterile inflammation and to potentiate the inflammatory response to microbial invasion. Besides operating in a broad biological context, biglycan also displays tissue-specific affinities to certain receptors and structural components, thereby playing a crucial role in bone formation, muscle integrity, and synapse stability at the neuromuscular junction. This review attempts to provide a concise summary of recent data regarding the involvement of biglycan in the regulation of inflammation and the musculoskeletal system, pointing out both a signaling and a structural role for this proteoglycan. The potential of biglycan as a novel therapeutic target or agent for the treatment of inflammatory diseases and skeletal muscular dystrophies is also addressed.
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Cites
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
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Self-citationMerline, R., Moreth, K., Beckmann, J., Nastase, M. V., Zeng-Brouwers, J., Tralhão, J. G., Lemarchand, P., Pfeilschifter, J., Schaefer, R. M., Iozzo, R. V., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001868 · Cited by 333
Self-citationMoreth, K., Brodbeck, R., Babelova, A., Gretz, N., Spieker, T., Zeng-Brouwers, J., Pfeilschifter, J., Young, M. F., Schaefer, R. M., & Schaefer, L. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42213 · Cited by 207
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Metadata
- Authors
- Nastase, M. V., Young, M. F., & Schaefer, L.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2012-07-20
- Volume
- 60
- Issue
- 12
- Pages
- 963-975
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2083163701
- Cited by
- 238
- References
- 7
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nastase, M. V., Young, M. F., & Schaefer, L. (2012). Biglycan: A Multivalent Proteoglycan Providing Structure and Signals. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1369/0022155412456380
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
