Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21
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A component of the extracellular matrix promotes inflammatory responses in sepsis and in tumors.
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Decorin controls inflammation and tumor growth through the PDCD4-miR21 axis.
“Merline et al. reported that decorin controls inflammation and tumor growth through PDCD4-miR21 axis [85].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [85]
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Decorin Antagonizes the Angiogenic Network
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EphA2 is a functional receptor for the growth factor progranulin
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miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis
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Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments
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Capillary leak and endothelial permeability in critically ill patients: a current overview
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The Role of Decorin and Biglycan Signaling in Tumorigenesis
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Bacterial Pathogens Activate a Common Inflammatory Pathway through IFNλ Regulation of PDCD4
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Endothelial glycocalyx degradation during sepsis: Causes and consequences
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Decorin deficiency promotes hepatic carcinogenesis
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Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy
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Oncosuppressive functions of decorin
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Small Leucine-Rich Proteoglycans in Skin Wound Healing
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MicroRNA and nephropathy: emerging concepts
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Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology
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Human testicular peritubular cells, mast cells and testicular inflammation
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Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation
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- Authors
- Merline, R., Moreth, K., Beckmann, J., Nastase, M. V., Zeng-Brouwers, J., Tralhão, J. G., Lemarchand, P., Pfeilschifter, J., Schaefer, R. M., Iozzo, R. V., & Schaefer, L.
- Affiliations
- Goethe University Frankfurt (DE)
- Unidade Local de Saúde de Coimbra (PT)
- Inserm (FR)
- University Hospital Münster (DE)
- Thomas Jefferson University (US)
- Corresponding author
- Iozzo, Renato V.
- Schaefer, Liliana
- ORCID
- Venue
- Science Signaling
- Published
- 2011-11-15
- Volume
- 4
- Issue
- 199
- Pages
- ra75-ra75
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5029092
- OpenAlex
- W2172216752
- Cited by
- 333
- References
- 72
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 13 · 2023: 23 · 2022: 27 · 2021: 27 · 2020: 34 · 2019: 21 · 2018: 23 · 2017: 17 · 2016: 16 · 2015: 32 · 2014: 22 · 2013: 27 · 2012: 18
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Cancer Institute (R01 CA-39481, R01CA047282, R01-CA47282, R01CA120975, R01CA039481)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- decorin, extracellular matrix proteoglycans, PDCD4, miR-21, TLR2, TLR4, macrophages, IL-10, sepsis, sterile inflammation, tumor growth, TGF-β1, protein synthesis inhibition, inflammation and cancer, tumor microenvironment
- MeSH terms
- Animals, Humans, Inflammation, Mice, Inbred C3H, Mice, Nude, Neoplasm Transplantation, Neoplasms, Transplantation, Heterologous, Signal Transduction, RNA-Binding Proteins, Interleukin-10, Macrophages, Peritoneal, Mice, Knockout, Sepsis, MicroRNAs, Cell Line, Tumor, Apoptosis Regulatory Proteins, Toll-Like Receptor 2, Toll-Like Receptor 4, Mice, Transforming Growth Factor beta1, Decorin
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