Cited by 333Proteoglycans and glycosaminoglycans researchTGF-β signaling in diseasesImmune Response and Inflammation

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

Open access
Merline, Rosetta, Moreth, Kristin, Beckmann, Janet, Nastase, Madalina V., Zeng-Brouwers, Jinyang, Tralhão, José Guilherme, Lemarchand, Patricia, Pfeilschifter, Josef +3 more·2011·Science Signaling

Abstract

A component of the extracellular matrix promotes inflammatory responses in sepsis and in tumors.

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Crossref · 10.1126/scisignal.2001868

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Authors
Merline, R., Moreth, K., Beckmann, J., Nastase, M. V., Zeng-Brouwers, J., Tralhão, J. G., Lemarchand, P., Pfeilschifter, J., Schaefer, R. M., Iozzo, R. V., & Schaefer, L.
Affiliations
  • Goethe University Frankfurt (DE)
  • Unidade Local de Saúde de Coimbra (PT)
  • Inserm (FR)
  • University Hospital Münster (DE)
  • Thomas Jefferson University (US)
Corresponding author
  • Iozzo, Renato V.
  • Schaefer, Liliana
Venue
Science Signaling
Published
2011-11-15
Volume
4
Issue
199
Pages
ra75-ra75
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2172216752
Cited by
333
References
72
Citations by year
2026: 10 · 2025: 22 · 2024: 13 · 2023: 23 · 2022: 27 · 2021: 27 · 2020: 34 · 2019: 21 · 2018: 23 · 2017: 17 · 2016: 16 · 2015: 32 · 2014: 22 · 2013: 27 · 2012: 18
FWCI
10.44
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
Funders
National Cancer Institute (R01 CA-39481, R01CA047282, R01-CA47282, R01CA120975, R01CA039481)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
decorin, extracellular matrix proteoglycans, PDCD4, miR-21, TLR2, TLR4, macrophages, IL-10, sepsis, sterile inflammation, tumor growth, TGF-β1, protein synthesis inhibition, inflammation and cancer, tumor microenvironment
MeSH terms
Animals, Humans, Inflammation, Mice, Inbred C3H, Mice, Nude, Neoplasm Transplantation, Neoplasms, Transplantation, Heterologous, Signal Transduction, RNA-Binding Proteins, Interleukin-10, Macrophages, Peritoneal, Mice, Knockout, Sepsis, MicroRNAs, Cell Line, Tumor, Apoptosis Regulatory Proteins, Toll-Like Receptor 2, Toll-Like Receptor 4, Mice, Transforming Growth Factor beta1, Decorin

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