The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Program of Gene Transcription for a Single Differentiating Cell Type during Sporulation in Bacillus subtilis
Open accessAbstract
Asymmetric division during sporulation by Bacillus subtilis generates a mother cell that undergoes a 5-h program of differentiation. The program is governed by a hierarchical cascade consisting of the transcription factors: sigma(E), sigma(K), GerE, GerR, and SpoIIID. The program consists of the activation and repression of 383 genes. The sigma(E) factor turns on 262 genes, including those for GerR and SpoIIID. These DNA-binding proteins downregulate almost half of the genes in the sigma(E) regulon. In addition, SpoIIID turns on ten genes, including genes involved in the appearance of sigma(K). Next, sigma(K) activates 75 additional genes, including that for GerE. This DNA-binding protein, in turn, represses half of the genes that had been activated by sigma(K) while switching on a final set of 36 genes. Evidence is presented that repression and activation contribute to proper morphogenesis. The program of gene expression is driven forward by its hierarchical organization and by the repressive effects of the DNA-binding proteins. The logic of the program is that of a linked series of feed-forward loops, which generate successive pulses of gene transcription. Similar regulatory circuits could be a common feature of other systems of cellular differentiation.
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Citations
Cites
Network motifs: simple building blocks of complex networks.
Milo, R., Shen-Orr, S., Itzkovitz, S., Kashtan, N., Chklovskii, D., & Alon, U. (2002) · Science · doi:10.1126/science.298.5594.824 · Cited by 7,368
Cited by
Network motifs: theory and experimental approaches
Alon, U. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2102 · Cited by 3,279
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Nicolas, P., Mäder, U., Dervyn, E., Rochat, T., Leduc, A., Pigeonneau, N., Bidnenko, E., Marchadier, E., Hoebeke, M., Aymerich, S., et al. (2012) · Science · doi:10.1126/science.1206848 · Cited by 910
Structure, Assembly, and Function of the Spore Surface Layers
Henriques, A. O., & Moran, Jr. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093224 · Cited by 587
Kussell, E., Kishony, R., Balaban, N. Q., & Leibler, S. (2005) · Genetics · doi:10.1534/genetics.104.035352 · Cited by 584
A module of negative feedback regulators defines growth factor signaling
Amit, I., Citri, A., Shay, T., Lu, Y., Katz, M., Zhang, F., Tarcic, G., Siwak, D., Lahad, J., Jacob-Hirsch, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1987 · Cited by 488
Metadata
- Authors
- Eichenberger, P., Fujita, M., Jensen, S. T., Conlon, E. M., Rudner, D. Z., Wang, S. T., Ferguson, C., Haga, K., Sato, T., Liu, J. S., & Losick, R.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-09-21
- Volume
- 2
- Issue
- 10
- Pages
- e328
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2021606207
- Cited by
- 367
- References
- 1
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- gold
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