The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System
Open accessAbstract
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration. GDNF has been tested in clinical trials for the treatment of Parkinson disease (PD), a common neurodegenerative disorder characterized by the loss of midbrain dopaminergic (DA) neurons. BDNF modulates nigrostriatal functions and rescues DA neurons in PD animal models. The physiological roles of GDNF and BDNF signaling in the adult nigrostriatal DA system are unknown. We generated mice with regionally selective ablations of the genes encoding the receptors for GDNF (Ret) and BDNF (TrkB). We find that Ret, but not TrkB, ablation causes progressive and adult-onset loss of DA neurons specifically in the substantia nigra pars compacta, degeneration of DA nerve terminals in striatum, and pronounced glial activation. These findings establish Ret as a critical regulator of long-term maintenance of the nigrostriatal DA system and suggest conditional Ret mutants as useful tools for gaining insights into the molecular mechanisms involved in the development of PD.
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Cites
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874
Expanding insights of mitochondrial dysfunction in Parkinson's disease
Abou-Sleiman, P. M., Muqit, M. M. K., & Wood, N. W. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1868 · Cited by 869
Day, M., Wang, Z., Ding, J., An, X., Ingham, C. A., Shering, A. F., Wokosin, D., Ilijic, E., Sun, Z., Sampson, A. R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1632 · Cited by 745 · cited 1×
“There is evidence that loss of DA neurons in the basal ganglia or dopamine depletion can lead to changes in the striatum, such as loss of spines and glutamatergic synapses [42] and may eventually lead to cell death [43].”
BackgroundLevivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274
Cited by
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
Lindholm, P., Voutilainen, M. H., Laurén, J., Peränen, J., Leppänen, V.-M., Andressoo, J.-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., et al. (2007) · Nature · doi:10.1038/nature05957 · Cited by 444
Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes
Drilon, A., Hu, Z. I., Lai, G. G. Y., & Tan, D. S. W. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.175 · Cited by 406
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
Kadkhodaei, B., Ito, T., Joodmardi, E., Mattsson, B., Rouillard, C., Carta, M., Muramatsu, S.-I., Sumi-Ichinose, C., Nomura, T., Metzger, D., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3910-09.2009 · Cited by 382
Absolute requirement of GDNF for adult catecholaminergic neuron survival
Pascual, A., Hidalgo-Figueroa, M., Piruat, J. I., Pintado, C. O., Gómez-Díaz, R., & López-Barneo, J. (2008) · Nature Neuroscience · doi:10.1038/nn.2136 · Cited by 334
BDNF is a negative modulator of morphine action
Koo, J. W., Mazei-Robison, M. S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D., et al. (2012) · Science · doi:10.1126/science.1222265 · Cited by 189
Metadata
- Authors
- Kramer, E. R., Aron, L., Ramakers, G. M. J., Seitz, S., Zhuang, X., Beyer, K., Smidt, M. P., & Klein, R.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-02-13
- Volume
- 5
- Issue
- 3
- Pages
- e39
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W1972515739
- Cited by
- 209
- References
- 6
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System. https://app.cochat.ai/papers/10.1371/journal.pbio.0050039
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- Kramer, E. R., Aron, L., Ramakers, G. M. J., Seitz, S., Zhuang, X., Beyer, K., Smidt, M. P., & Klein, R. (2007). Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System. PLoS Biology. https://doi.org/10.1371/journal.pbio.0050039
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
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