Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease
Abstract
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.
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BDNF and GDNF are dopamine-active neurotrophic proteins that can promote the survival of dopaminergic neurons and play an important role in neurite growth.
“BDNF and GDNF are dopamine-active neurotrophic proteins that can promote the survival of dopaminergic neurons and play an important role in neurite growth [28].”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [28]
In the hippocampus, BDNF promotes the production and survival of new neurons from stem cells and the integration of new neurons into existing neuronal circuits.
“In the hippocampus, BDNF promotes the production and survival of new neurons from stem cells and the integration of new neurons into existing neuronal circuits [141], reviewed in [160].”
From The neuropathology of sport (2014) · cites this paper as [141]
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- Authors
- Murer, M. G., Yan, Q., & Raisman-Vozari, R.
- Affiliations
- Universidad de Buenos Aires (AR)
- Amgen (United States) (US)
- Corresponding author
- Murer, M.G
- ORCID
- Murer, M.G
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 63
- Issue
- 1
- Pages
- 71-124
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2063849763
- Cited by
- 874
- References
- 551
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 26 · 2023: 34 · 2022: 29 · 2021: 36 · 2020: 44 · 2019: 45 · 2018: 27 · 2017: 39 · 2016: 52 · 2015: 40 · 2014: 42 · 2013: 52 · 2012: 45
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- brain-derived neurotrophic factor, Alzheimer's disease, Parkinson's disease, neurotrophins, nerve growth factor, intracellular trafficking, neuronal survival, dopaminergic neurons, cholinergic neurons, hippocampal neurons, neurodegeneration
- MeSH terms
- Alzheimer Disease, Brain, Humans, Parkinson Disease, Reference Values, Tissue Distribution, Brain-Derived Neurotrophic Factor
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