The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
The Circadian Clock Regulates Auxin Signaling and Responses in Arabidopsis
Open accessAbstract
The circadian clock plays a pervasive role in the temporal regulation of plant physiology, environmental responsiveness, and development. In contrast, the phytohormone auxin plays a similarly far-reaching role in the spatial regulation of plant growth and development. Went and Thimann noted 70 years ago that plant sensitivity to auxin varied according to the time of day, an observation that they could not explain. Here we present work that explains this puzzle, demonstrating that the circadian clock regulates auxin signal transduction. Using genome-wide transcriptional profiling, we found many auxin-induced genes are under clock regulation. We verified that endogenous auxin signaling is clock regulated with a luciferase-based assay. Exogenous auxin has only modest effects on the plant clock, but the clock controls plant sensitivity to applied auxin. Notably, we found both transcriptional and growth responses to exogenous auxin are gated by the clock. Thus the circadian clock regulates some, and perhaps all, auxin responses. Consequently, many aspects of plant physiology not previously thought to be under circadian control may show time-of-day-specific sensitivity, with likely important consequences for plant growth and environmental responses.
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Cites
Auxin: Regulation, Action, and Interaction
WOODWARD, A. W. (2005) · Annals of Botany · doi:10.1093/aob/mci083 · Cited by 2,340
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. B., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,290
Mechanism of auxin perception by the TIR1 ubiquitin ligase
Tan, X., Calderon-Villalobos, L. I. A., Sharon, M., Zheng, C., Robinson, C. V., Estelle, M., & Zheng, N. (2007) · Nature · doi:10.1038/nature05731 · Cited by 1,688
Orchestrated Transcription of Key Pathways in Arabidopsis by the Circadian Clock
Harmer, S. L., Hogenesch, J. B., Straume, M., Chang, H.-S., Han, B., Zhu, T., Wang, X., Kreps, J. A., & Kay, S. A. (2000) · Science · doi:10.1126/science.290.5499.2110 · Cited by 1,640
Self-citationPlant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage
Dodd, A. N., Salathia, N., Hall, A., Kévei, E., Tóth, R., Nagy, F., Hibberd, J. M., Millar, A. J., & Webb, A. A. R. (2005) · Science · doi:10.1126/science.1115581 · Cited by 1,487
Auxin in action: signalling, transport and the control of plant growth and development
Teale, W. D., Paponov, I. A., & Palme, K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2020 · Cited by 1,317
Reciprocal Regulation Between TOC1 and LHY / CCA1 Within the Arabidopsis Circadian Clock
Alabadı́, D., Oyama, T., Yanovsky, M. J., Harmon, F. G., Más, P., & Kay, S. A. (2001) · Science · doi:10.1126/science.1061320 · Cited by 1,161
Time zones: a comparative genetics of circadian clocks
Young, M. W., & Kay, S. A. (2001) · Nature Reviews Genetics · doi:10.1038/35088576 · Cited by 1,157
Characterization of an Arabidopsis Enzyme Family That Conjugates Amino Acids to Indole-3-Acetic Acid
Staswick, P. E., Serban, B., Rowe, M., Tiryaki, I., Maldonado, M. T., Maldonado, M. C., & Suza, W. (2005) · The Plant Cell · doi:10.1105/tpc.104.026690 · Cited by 1,132
The Roles of Auxin Response Factor Domains in Auxin-Responsive Transcription
Tiwari, S. B., Hagen, G., & Guilfoyle, T. (2003) · The Plant Cell · doi:10.1105/tpc.008417 · Cited by 1,007
Cited by
Covington, M. F., Maloof, J. N., Straume, M., Kay, S. A., & Harmer, S. L. (2008) · Genome Biology · doi:10.1186/gb-2008-9-8-r130 · Cited by 747
Self-citationThe Circadian System in Higher Plants
Harmer, S. L. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.043008.092054 · Cited by 719
Self-citationStrigolactone Acts Downstream of Auxin to Regulate Bud Outgrowth in Pea and Arabidopsis
Brewer, P. B., Dun, E. A., Ferguson, B. J., Rameau, C., & Beveridge, C. A. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.134783 · Cited by 418
“Arabidopsis and pea have the ability to transport excess IAA, which, for example, may act as a buffer during circadian fluctuations in auxin levels (Covington and Harmer, 2007) or when new primordia or flower buds produce and transport new auxin into the polar auxin transport stream (Benková et…”
BackgroundTemperature perception and signal transduction in plants
Penfield, S. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02478.x · Cited by 419
Wheels within wheels: the plant circadian system
Hsu, P. Y., & Harmer, S. L. (2014) · Trends in Plant Science · doi:10.1016/j.tplants.2013.11.007 · Cited by 379
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Metadata
- Authors
- Covington, M. F., & Harmer, S. L.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-08-07
- Volume
- 5
- Issue
- 8
- Pages
- e222
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2016076879
- Cited by
- 364
- References
- 73
- FWCI
- 28.49
- Type
- journal article
- Language
- en
- Open access
- gold
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