The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Kittappa, Raja, Chang, Wendy W, Awatramani, Rajeshwar B, McKay, Ronald D. G·2007·PLoS Biology

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  3. Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation
    Chia‐Chou Wu, Che Lin, Bor‐Sen Chen · 2015 · Stem Cells International
  4. Regulation of the Serotonin Neuron Fate in Stem Cells by foxa2 and shh
    Raja Kittappa · 2017 · Journal of Stem Cell Research & Therapeutics
  5. Brainstem organoids from human pluripotent stem cells contain neural crest population
    Nobuyuki Eura, Takeshi K. Matsui, Joachim Luginbühl, Masaya Matsubayashi, Hitoki Nanaura, Tomo Shiota, Kaoru Kinugawa, Naohiko Iguchi, Takao Kiriyama, Canbin Zheng et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Familial Parkinson’s Disease Mutations Converge on Alternative Splicing Programs Linked to Lysosomal, Autophagic and Vesicle Trafficking Pathways
    Yeon J. Lee, Khaja Mohieddin Syed, Oriol Busquets, Hanqin Li, Jesse Dunnack, Helen S. Bateup, Frank Soldner, Dirk F. Hockemeyer, Donald C. Rio · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  7. Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson’s disease
    Jessica Jiaxin Xie, Matas Vitkauskas, Quyen Do, Tzuen Yih Saw, Alfred Xuyang Sun, Lin Yang, Tuck Wah Soong, Lim Kah‐Leong, Eng‐King Tan, Huck‐Hui Ng et al. · 2026 · iScience
  8. Nurr1: A New Insight to Protects Dopaminergic Neurodegeneration in Parkinson’s disease
    2015 · Therapeutic Targets for Neurological Diseases
  9. 4.1 Genetic Control of Meso-diencephalic Dopaminergic Neuron Development in Rodents
    Wolfgang Wurst, Nilima Prakash · 2009
  10. Big Regeneration Mechanisms via Systems Biology and Big Database Mining Methods
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  11. Compositions and methods for treatment of Parkinson's disease: a patent evaluation of WO2011/102847A1
    Valerio Chiurchiù, Mauro Maccarrone, Antonio Orlacchio · 2012 · Expert Opinion on Therapeutic Patents
  12. Progress in generating iPSC-derived dopaminergic neurons as accurate models of neurodegenerative disease
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  13. A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology
    Aditi Chandra, Sora Yoon, Michaël F. Michieletto, Naomi Goldman, Emily K. Ferrari, Maria Fasolino, Leonel D. Joannas, Barbara L. Kee, Jorge Henao‐Mejia, Golnaz Vahedi · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  14. LRP10 as a novel α-synuclein regulator in Lewy body diseases
    Ana Carreras Mascaro, Martyna M. Grochowska, Valerie Boumeester, Natasja F. J. Dits, Ece Naz Bilgiҫ, Guido J. Breedveld, Leonie J.M. Vergouw, Frank Jan de Jong, Martin E. van Royen, Vincenzo Bonifati et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  15. GBA1 mutations alter neuronal firing and structure, regulating VGLUT2 and CRYAB in dopamine neurons
    Eva Rodríguez‐Traver, Luz M. Suárez, Carlos Crespo, Irene González-Burgos, Rebeca Vecino, Juan Camilo Jurado-Coronel, María Galán, Marta González-González, Rosario Moratalla, Carlos Vicario‐Abejón · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Embryonic stem cell-based models of parkinson's disease
    Mark J. Tomishima, Lorenz Studer · 2008 · Elsevier eBooks
  17. Parkinson disease: identifying different players sharing a common principle
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  18. When new neurons become functional
    Kirill Tokarev · 2010 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
  19. A Survey of the Molecular Basis for the Generation of Functional Dopaminergic Neurons from Pluripotent Stem Cells: Insights from Regenerative Biology and Regenerative Medicine
    Kaneyasu Nishimura, Yoshihisa Kitamura, Kiyokazu Agata, Jun Takahashi · 2013 · InTech eBooks
  20. Funktionelle Analyse des Transkriptionsfaktors Uncx4.1 im murinen Mittelhirn
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  21. DERIVATION, ENRICHMENT AND CHARACTERIZATION OF DOPAMINERGIC NEURONS FROM PLURIPOTENT STEM CELLS
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  22. Transcription factor control in neuronal maintenance and survival
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  23. Influence of culture conditions on the molecular signature of mesenchymal stem cells
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  24. Generation of dopamine neurons in vivo and from embryonic stem cells in vitro
    Stina Friling · 2009 · Figshare
  25. Funktionelle Analyse des Transkriptionsfaktors Pitx3 während der Entwicklung dopaminerger Neuronen im murinen Mittelhirn
    Christian Krug · 2013
  26. Regional control of cell fate determination and neurogenesis in the developing CNS
    Ulrika Marklund · 2008 · Figshare
  27. Mechanisms of Wnt signaling: from embryonic stem cells to dopaminergic neurons
    Lukáš Čajánek · 2011 · Figshare
  28. Foxa2, une nouvelle piste neuro-développementale pour le Parkinson
    Jacques Epelbaum · 2008 · médecine/sciences
  29. Stem Cell Transplantation for Neurodegenerative Disease: A Distant Dream?
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  30. Genetics as a tool for the dissociation of mental operations over the course of development
    John Fossella, Kevin G. Guise, Jin Fan · 2010 · Annals of the New York Academy of Sciences
  31. THE ROLE OF LMX1A AND LMX1B IN REGULATING MESENCEPHALON DEVELOPMENT AND DOPAMINE NEURON SPECIFICATION
    Qiaolin Deng · 2010 · Figshare
  32. CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery
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  33. Regenerating the brain : lessons from the Red Spotted Newt
    Daniel A. Berg · 2012 · Figshare
  34. Determining the Role of Sonic Hedgehog in Establishing Midbrain Dopaminergic Neuron Subclasses
    Anna Kabanova · 2013 · bonndoc (University of Bonn)
  35. The role of the foxa2 gene in the birth and death of dopamine neurons
    Raja Kittappa, Wendy Chang, Ronald D.G. McKay · 2008 · Elsevier eBooks
  36. Temporal Control of Organogenesis by PHA-4/FOXA
    Hui-Ting Hsu · 2014 · J. Willard Marriott Library
  37. Midbrain dopaminergic neuron fate specification of pluripotent stem cells
    Ines Stephanie Jaeger · 2012 · Spiral (Imperial College London)
  38. Transcriptional Regulation of Drosophila Neural Development
    Stephanie B. Stagg · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  39. Molecular mechanisms involved in midbrain dopaminergic neuron migration during murine development
    Gabriela Oana Bodea · 2014 · bonndoc (University of Bonn)
  40. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor
    Federico Miozzo, Luca Stickley, Eva P. Valencia-Alarcón, Michaëla Majcin Dorcikova, Francesco Petrelli, Damla Tas, Nicolas Loncle, Irina Nikonenko, Peter Bou Dib, Emi Nagoshi · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  41. iPSCs and cell therapy for Parkinson’s disease
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  43. Discovery of functional non-coding conserved regions in the α-synuclein gene locus
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  44. GBA1 mutations alter neuronal excitability and ultrastructure in Parkinson´s disease, regulating VGLUT2 and CRYAB in dopaminergic neurons
    Eva Rodríguez‐Traver, Luz M. Suárez, Carlos Crespo, Irene González-Burgos, Rebeca Vecino, Juan Camilo Jurado-Coronel, María Galán, Marta González-González, Eva Díaz‐Guerra, Rosario Moratalla et al. · 2024 · Research Square
  45. Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons
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  46. NATO3 protects dopaminergic neurons in mouse in vivo and human in vitro Parkinson’s disease models
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  47. Current Research on Stem Cells in Parkinson’s Disease: Progress and Challenges
    Ria Thomas, Jan Pruszak · 2013 · Stem cell biology and regenerative medicine
  48. Potentiel thérapeutique de neurones dopaminergiques dérivés de cellules souches embryonnaires de souris dans un modèle murin de la maladie de Parkinson
    Sandie Brisson · 2017
  49. Aberrant CD4 + T cell refeeding response impairs neuro-immune crosstalk in Parkinson’s disease
    Karl Austin‐Muttitt, Bethan R David, Martina Sassi, Ravi Agarwal, Thaís S. Sabedot, Jeffrey R. Jones, Michael S. Cuoco, Benjamin J. Jenkins, Luke D. Roberts, Leo Harris et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Combinatorial mechanisms specify cellular location and neurotransmitter identity during planarian neurogenesis
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