The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Specific Targeting of a Plasmodesmal Protein Affecting Cell-to-Cell Communication
Open accessAbstract
Plasmodesmata provide the cytoplasmic conduits for cell-to-cell communication throughout plant tissues and participate in a diverse set of non-cell-autonomous functions. Despite their central role in growth and development and defence, resolving their modus operandi remains a major challenge in plant biology. Features of protein sequences and/or structure that determine protein targeting to plasmodesmata were previously unknown. We identify here a novel family of plasmodesmata-located proteins (called PDLP1) whose members have the features of type I membrane receptor-like proteins. We focus our studies on the first identified type member (namely At5g43980, or PDLP1a) and show that, following its altered expression, it is effective in modulating cell-to-cell trafficking. PDLP1a is targeted to plasmodesmata via the secretory pathway in a Brefeldin A-sensitive and COPII-dependent manner, and resides at plasmodesmata with its C-terminus in the cytoplasmic domain and its N-terminus in the apoplast. Using a deletion analysis, we show that the single transmembrane domain (TMD) of PDLP1a contains all the information necessary for intracellular targeting of this type I membrane protein to plasmodesmata, such that the TMD can be used to target heterologous proteins to this location. These studies identify a new family of plasmodesmal proteins that affect cell-to-cell communication. They exhibit a mode of intracellular trafficking and targeting novel for plant biology and provide technological opportunities for targeting different proteins to plasmodesmata to aid in plasmodesmal characterisation.
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Metadata
- Authors
- Thomas, C. L., Bayer, E. M., Ritzenthaler, C., Fernandez-Calvino, L., & Maule, A. J.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-01-22
- Volume
- 6
- Issue
- 1
- Pages
- e7
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2023001306
- Cited by
- 358
- References
- 30
- FWCI
- 23.14
- Type
- journal article
- Language
- en
- Open access
- gold
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