The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region
Open accessAbstract
Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear. Here we show that the physical distance between the termination codon and the poly(A)-binding protein PABPC1 is a crucial determinant for PTC recognition in human cells. "Normal" termination codons can trigger nonsense-mediated mRNA decay (NMD) when this distance is extended; and vice versa, NMD can be suppressed by folding the poly(A) tail into proximity of a PTC or by tethering of PABPC1 nearby a PTC, indicating an evolutionarily conserved function of PABPC1 in promoting correct translation termination and antagonizing activation of NMD. Most importantly, our results demonstrate that spatial rearrangements of the 3' untranslated region can modulate the NMD pathway and thereby provide a novel mechanism for posttranscriptional gene regulation.
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Cites
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PTC124 targets genetic disorders caused by nonsense mutations
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Cited by
Regulation of cytoplasmic mRNA decay
Schoenberg, D. R., & Maquat, L. E. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3160 · Cited by 656
NMD: a multifaceted response to premature translational termination
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High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation
Veyrieras, J.-B., Kudaravalli, S., Kim, S. Y., Dermitzakis, E. T., Gilad, Y., Stephens, M., & Pritchard, J. K. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000214 · Cited by 536
Mechanism and regulation of the nonsense-mediated decay pathway
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Kurosaki, T., & Maquat, L. E. (2016) · Journal of Cell Science · doi:10.1242/jcs.181008 · Cited by 396
Metadata
- Authors
- Eberle, A. B., Stalder, L., Mathys, H., Orozco, R. Z., & Mühlemann, O.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-04-29
- Volume
- 6
- Issue
- 4
- Pages
- e92
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2058490761
- Cited by
- 300
- References
- 51
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Eberle, A. B., Stalder, L., Mathys, H., Orozco, R. Z., & Mühlemann, O. (2008). Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region. PLoS Biology. https://doi.org/10.1371/journal.pbio.0060092
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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