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Cited by 153

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

Hemming, Matthew L, Elias, Joshua E, Gygi, Steven P, Selkoe, Dennis J·2008·PLoS Biology
DOI 10.1371/journal.pbio.0060257PMC PMC2570425
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Crossref · 10.1371/journal.pbio.0060257

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  • An unbiased proteomics screen identified but did not experimentally validate a potential candidate for the γ-secretase effect on hepatocyte TRL uptake, the LDL receptor (LDLR).

    “To this end, an unbiased proteomics screen (Hemming et al., 2008) identified but did not experimentally validate a potential candidate for the γ-secretase effect on hepatocyte TRL uptake, the LDL receptor (LDLR).”

    From γ-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor (2018) · cites this paper as Hemming et al., 2008

    The Results section on substrate identification describes an unbiased proteomics screen, but says it identified a protein with a closely related homologue—the LDL receptor (LDLR)—that had previously been identified as a γ-secretase substrate. It does not say the screen identified LDLR itself. The validation section lists the proteins experimentally tested and does not include LDLR; the paper does not examine hepatocyte TRL uptake. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The accumulation of C-terminal fragments upon pharmacological inhibition of γ-secretase with DAPT can be used to identify γ-secretase substrates.

    “The accumulation of C-terminal fragments upon pharmacological inhibition of γ-secretase with DAPT can be used to identify γ-secretase substrates [42].”

    From Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (2016) · cites this paper as [42]

  • Both LDLR and LRP1 have been reported as putative γ-secretase targets.

    “As both LDLR and LRP1 have been reported as putative γ-secretase targets (Hemming et al., 2008)”

    From γ-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor (2018) · cites this paper as Hemming et al., 2008

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Research works printed but not linked: 72

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Metadata

Authors
Hemming, M. L., Elias, J. E., Gygi, S. P., & Selkoe, D. J.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2008-10-21
Volume
6
Issue
10
Pages
e257
ISSN
1545-7885
DOI
10.1371/journal.pbio.0060257
PMC
PMC2570425
Cited by
153
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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