Modulation of γ- and β-secretases as early prevention against Alzheimer's disease
Open accessAbstract
The genetic evidence implicating amyloid-β in the initial stage of Alzheimer's disease is unequivocal. However, the long biochemical and cellular prodromal phases of the disease suggest that dementia is the result of a series of molecular and cellular cascades whose nature and connections remain unknown. Therefore, it is unlikely that treatments directed at amyloid-β will have major clinical effects in the later stages of the disease. We discuss the two major candidate therapeutic targets to lower amyloid-β in a preventive mode, i.e., γ- and β-secretase; the rationale behind these two targets; and the current state of the field.
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Cholinesterase inhibitors have a useful, modest role in improving cognition and activities of daily living in patients with mild-to-moderate Alzheimer's disease, and memantine can be prescribed in combination or each drug used separately for moderate and severe Alzheimer's disease.
“Cholinesterase inhibitors have a useful, modest role in improving cognition and activities of daily living in patients with mild-to-moderate Alzheimer's disease and memantine can be prescribed in combination or each drug used separately for moderate and severe Alzheimer's disease.2, 199, 200”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [200]
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredThe level of TREM2 on the cell membrane is regulated by ADAMs, which cleave full-length TREM2 into sTREM2.
“The level of TREM2 on the surface of cell membrane is regulated by a disintegrin and metalloproteinases (ADAMs) which constantly cleave full-length TREM2 into sTREM2, regulating the speed of ADAMs mediated shedding is another way to intervene in TREM2 signaling.538”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [538]
The Introduction and “Substrate recruitment and cleavage” section discuss γ- and β-secretases, but do not address TREM2 shedding. A References entry mentions ADAM17 cleavage of neuregulin 1, not TREM2. Searches for TREM2, sTREM2, and ADAM-mediated shedding found no passage supporting the attributed claim; page numbers were unavailable. (LLM, conf=0.74)
Experimental — accuracy not yet measuredRegulating the speed of ADAMs mediated shedding is another way to intervene in TREM2 signaling.
“regulating the speed of ADAMs mediated shedding is another way to intervene in TREM2 signaling.538”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [538]
The BACE1 therapeutic-target and Conclusion sections discuss modulating β- and γ-secretases to affect amyloid-β, but do not address TREM2 signaling. A search for TREM2 and ADAM-mediated shedding found only a References entry about ADAM17 cleavage of neuregulin, not TREM2; page numbers were unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured4D9, a dual-function TREM2 antibody, reduces shedding of TREM2 by ADAMs and concomitantly activates pSYK signaling.
“A dual-function TREM2 antibody, 4D9, has been developed to reduce the shedding of TREM2 by ADAMs and concomitantly activate pSYK signaling.538”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [538]
The BACE1 therapy section discusses inhibitory antibodies against BACE1, not the TREM2 antibody 4D9. Searches of our full-text copy for 4D9, TREM2, ADAM-mediated shedding, and pSYK signaling found no passage addressing the attributed mechanism. (LLM, conf=0.77)
Experimental — accuracy not yet measured4D9 improved survival of macrophages and increased uptake of myelin debris and Aβ peptides by microglia.
“The 4D9 antibody improved the survival of macrophages and increased the uptake of myelin debris and Aβ peptides by microglia.”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [538]
The Introduction discusses antibodies against Aβ, and the BACE1 function and its substrates section discusses myelination, but neither addresses the claimed effects of 4D9. Searches for 4D9, macrophage survival, and microglial uptake of myelin debris or Aβ peptides found no supporting passage in our copy; page numbers were unavailable. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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- Authors
- Voytyuk, I., De Strooper, B., & Chávez-Gutiérrez, L.
- Affiliations
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 83
- Issue
- 4
- Pages
- 320-327
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2743054687
- Cited by
- 67
- References
- 113
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 17 · 2018: 11
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (submittedVersion)
- Funders
- Medical Research Council (MC_PC_17116)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, amyloid-beta, gamma-secretase, beta-secretase, prophylaxis, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Humans, Amyloid beta-Peptides, Amyloid Precursor Protein Secretases
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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