The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
RIN4 Functions with Plasma Membrane H+-ATPases to Regulate Stomatal Apertures during Pathogen Attack
Open accessAbstract
Pathogen perception by the plant innate immune system is of central importance to plant survival and productivity. The Arabidopsis protein RIN4 is a negative regulator of plant immunity. In order to identify additional proteins involved in RIN4-mediated immune signal transduction, we purified components of the RIN4 protein complex. We identified six novel proteins that had not previously been implicated in RIN4 signaling, including the plasma membrane (PM) H(+)-ATPases AHA1 and/or AHA2. RIN4 interacts with AHA1 and AHA2 both in vitro and in vivo. RIN4 overexpression and knockout lines exhibit differential PM H(+)-ATPase activity. PM H(+)-ATPase activation induces stomatal opening, enabling bacteria to gain entry into the plant leaf; inactivation induces stomatal closure thus restricting bacterial invasion. The rin4 knockout line exhibited reduced PM H(+)-ATPase activity and, importantly, its stomata could not be re-opened by virulent Pseudomonas syringae. We also demonstrate that RIN4 is expressed in guard cells, highlighting the importance of this cell type in innate immunity. These results indicate that the Arabidopsis protein RIN4 functions with the PM H(+)-ATPase to regulate stomatal apertures, inhibiting the entry of bacterial pathogens into the plant leaf during infection.
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,366
Snedecor, G. W., & Cochran, W. G. (1967) · Cited by 6,573
Keller, A., Nesvizhskii, A. I., Kolker, E., & Aebersold, R. (2002) · Analytical Chemistry · doi:10.1021/ac025747h · Cited by 4,830
A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry
Nesvizhskii, A. I., Keller, A., Kolker, E., & Aebersold, R. (2003) · Analytical Chemistry · doi:10.1021/ac0341261 · Cited by 4,809
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
Chisholm, S. T., Coaker, G., Day, B., & Staskawicz, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.008 · Cited by 2,957
Self-citationThe role of stomata in sensing and driving environmental change
Hetherington, A. M., & Woodward, F. I. (2003) · Nature · doi:10.1038/nature01843 · Cited by 2,399
Plant Stomata Function in Innate Immunity against Bacterial Invasion
Melotto, M., Underwood, W., Koczan, J., Nomura, K., & He, S. Y. (2006) · Cell · doi:10.1016/j.cell.2006.06.054 · Cited by 1,981
Sparkes, I. A., Runions, J., Kearns, A., & Hawes, C. (2006) · Nature Protocols · doi:10.1038/nprot.2006.286 · Cited by 1,906
Genome-Wide Analysis of NBS-LRR–Encoding Genes in Arabidopsis[W]
Meyers, B. C., Kozik, A., Griego, A., Kuang, H., & Michelmore, R. W. (2003) · The Plant Cell · doi:10.1105/tpc.009308 · Cited by 1,605
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Plant immunity: towards an integrated view of plant–pathogen interactions
Dodds, P. N., & Rathjen, J. P. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2812 · Cited by 3,424
Lee, D., Lal, N. K., Lin, Z.-J. D., Ma, S., Liu, J., Castro, B., Toruño, T., Dinesh-Kumar, S. P., & Coaker, G. (2020) · Nature Communications · doi:10.1038/s41467-020-15601-5 · Cited by 319
Self-citationH + -ATPases in Plant Growth and Stress Responses
Li, Y., Zeng, H., Xu, F., Yan, F., & Xu, W. (2022) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-102820-114551 · Cited by 161
Plant proton pumps: regulatory circuits involving H+-ATPase and H+-PPase
Fuglsang, A. T., Paez-Valencia, J., & Gaxiola, R. A. (2011) · Signaling and Communication in Plants · doi:10.1007/978-3-642-14369-4_2 · Cited by 48
Self-citationDemethoxycurcumin Is A Potent Inhibitor of P-Type ATPases from Diverse Kingdoms of Life
Dao, T. T., Sehgal, P., Tung, T. T., Møller, J. V., Nielsen, J., Palmgren, M., Christensen, S. B., & Fuglsang, A. T. (2016) · PLOS ONE · doi:10.1371/journal.pone.0163260 · Cited by 25
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Metadata
- Authors
- Liu, J., Elmore, J. M., Fuglsang, A. T., Palmgren, M. G., Staskawicz, B. J., & Coaker, G.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-06-30
- Volume
- 7
- Issue
- 6
- Pages
- e1000139
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W1966703024
- Cited by
- 275
- References
- 65
- FWCI
- 27.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, J., Elmore, J. M., Fuglsang, A. T., Palmgren, M. G., Staskawicz, B. J., & Coaker, G. (2009). RIN4 Functions with Plasma Membrane H+-ATPases to Regulate Stomatal Apertures during Pathogen Attack. PLoS Biology. https://doi.org/10.1371/journal.pbio.1000139
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