Publication bias in reports of animal stroke studies leads to major overstatement of efficacy

Sena, Emily S., van der Worp, H. Bart, Bath, Philip M. W., Howells, David W., Macleod, Malcolm R.·2010·PLoS Biology

Cited by (598)

Items 501–598 of 598

  1. Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning
    S., Tauskela Joseph, Nicolas Blondeau · 2019 · arXiv (Cornell University)
  2. Author response: Four erroneous beliefs thwarting more trustworthy research
    Mark A. Yarborough, Robert Nadon, David Karlin · 2019 · eLife
  3. Valid statistical approaches for clustered data: A Monte Carlo simulation study
    Kristen A. McLaurin, Amanda Jane Fairchild, Dexin Shi, Rosemarie M. Booze, Charles F. Mactutus · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Tools to enable animal to human translation
    Guilherme S. Ferreira · 2020
  5. Research Integrity: A primer on research involving animals
    UKRIO, Nikki Osborne · 2021
  6. News in brief
    2010 · Nature Medicine
  7. The laboratory mouse
    Kathleen R. Pritchett‐Corning, Joseph Paul Garner · 2024 · Wiley eBooks
  8. Translational neuroscience requires better design and analysis of preclinical studies
    Stanley E. Lazic · 2012 · Nature Precedings
  9. Large-Scale Assessment of Animal-to-Human Drug Translation Using Natural Language Processing
    Simona Emilova Doneva, Tilia Ellendorff, Gerold Schneider, Leonhard Held, Viktor von Wyl, T. Ian Simpson, Beate Sick, Benjamin Victor Ineichen · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Experimentelle Ansätze zur Therapie des ischämischen Schlaganfalls
    Christoph Kleinschnitz, Nikolaus Plesnila · 2012 · Der Nervenarzt
  11. Increasing value and reducing waste in animal models of rheumatological disease
    Gillian L. Currie, Malcolm Robert Macleod · 2015 · International Journal of Rheumatic Diseases
  12. Bias Detection: Study Identifies Instruments for Evaluating Animal Studies
    Kellyn S. Betts · 2013 · Environmental Health Perspectives
  13. Scientific Non-Publishing: The Addressed, the Unaddressed and the Unexplored
    Rayanta Joshi, Ashish Agrawal, Vatsal Shah · 2014 · Pharmacology
  14. Evaluating pain-related behavior in spinal cord injury
    Cathrine Baastrup · 2012 · Scandinavian Journal of Pain
  15. Standardized Reporting, Registration, and a Multicenter, Multispecies Approach to Preclinical (Animal) Trials
    Michael Charles Reade, Emrys Kirkman · 2013 · Annual update in intensive care and emergency medicine
  16. Research: increasing value, reducing waste 4 Increasing value and reducing waste: addressing inaccessible research
    An‐Wen Chan, Fujian Song, Andrew Julian Vickers, Tom Jeff Erson, Kay Dickersin, Peter Christian Gøtzsche, Harlan M Krumholz, Davina Ghersi, H Bart Van Der Worp · 2015
  17. Pre-clinical biomedical research
    Denia ia Morales Navarro · 2015 · DOAJ (DOAJ: Directory of Open Access Journals)
  18. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? Public acceptance of the use of animals in biomedical research is conditional on it producing benefits for humans. Pandora Pound and Michael Bracken argue that the benefits remain unproved and may divert funds from research that is more relevant to doctors and their patients
    Pandora Pound · 2014
  19. CardioPulse Articles
    Simon Capewell, Kristoffer Andersen · 2011 · European Heart Journal
  20. Implementation of systematic reviews in EFSA scientific outputs workflow (CFT/EFSA/AMU/2010/01) 1
    Annette M. Cormier O'Connor, Gábor L. Löveï, Jacqualyn F. Eales, Julie Glanville, Jan M. Sargeant · 2012
  21. Cannabinoids in experimental stroke: a systematic review and
    Timothy J. England, William H. Hind, Nadiah A Rasid · 2014
  22. Section summary and perspectives: Translational medicine in neurology
    James E. Barrett, Joseph T. Coyle · 2012 · Cambridge University Press eBooks
  23. “Therapeutic Imaging”: Image-Guided Therapies in Emergency Medicine
    Joshua Seth Broder · 2010 · Elsevier eBooks
  24. 77. Mouse models: some reflections from the lab
    Anne Blanchard · 2016 · Congress of the European Society for Agricultural and Food Ethics (EurSafe)
  25. Making bodies commensurate: The social construction of humans, animals, and microbes as objects of scientific study
    Kimberly L. Kelly · 2016 · UA Campus Repository (The University of Arizona)
  26. History of Experimental Stroke Research
    Victoria E. O’Collins · 2017 · Springer series in translational stroke research
  27. Design and analysis of biomedical studies
    Merete Kjær Hansen · 2015
  28. Development of imaging methods for the lithium-pilocarpine model of epilepsy
    Ben A. Duffy · 2014 · UCL Discovery (University College London)
  29. The Economics of Reproducibility in
    Leonard P. Freedman, Iain Cockburn, Timothy S. Simcoe · 2015
  30. Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
    Brandon Dixon · 2016 · The Scholars Repository - LLU (Loma Linda University)
  31. Future of Regulatory Safety Assessments
    Gerd Bode, Petra Starck-Lantova · 2018 · Springer eBooks
  32. Decision letter: Four erroneous beliefs thwarting more trustworthy research
    2019 · eLife
  33. What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression
    H. Hunter, D. de Gracia Hahn, Amedine Duret, Y. Im, Q. Cheah, Jiawen Dong, M. Fairey, Clarissa Hjalmarsson, Alice Li, Hong Lim et al. · 2019 · bioRxiv
  34. Research Integrity: A primer on research involving animals
    Nikki Osborne · 2019
  35. Limitations and Flaws of Preclinical Pulmonary Hypertension Studies
    Tsukasa Shimauchi, François Potus, Sébastien Bonnet, Steeve Provencher, Roxane Paulin, Olivier Boucherat · 2020 · Advances in Pulmonary Hypertension
  36. The Solution to Science's Replication Crisis
    Bruce Knuteson · 2016 · RePEc: Research Papers in Economics
  37. Die Genehmigung von Tierversuchen nach Richtlinie 2010/63/EU – zentrale Konzepte zur Prüfung der „ethischen Vertretbarkeit“, ihre Funktion, praktische Schwierigkeiten und die Beschränkung ihrer „ethis...
    Matthias Eggel · 2021 · Nomos Verlagsgesellschaft mbH & Co. KG eBooks
  38. Claims and statistical inference in animal physical cognition research.
    Benjamin George Farrar, Drew Altschul, Julia Fischer, Joléne van der Mescht, Sarah Placì, Camille Aurélie Troisi, Alizée Vernouillet, Nicola Susan Clayton, Ljerka Ostojić · 2020
  39. Epicardial Delivery of Cardiosphere Derived Cells or Their Extracellular Vesicles in a Relevant Infarcted Swine Model: Safe, Easy but of Limited Effectiveness.
    Verónica Crisóstomo, Claudia Báez-Díaz, Virginia Blanco, Verónica Álvarez, Esther Lopez-Nieto, Juan Maestre, Antoni Bayés‐Genís, Carolina Gálvez‐Montón, Javier G. Casado, Francisco Miguel Sanchez-Margallo · 2021 · Research Square
  40. Leaps of logic: quantifying the behavioural relevance of hippocampal neurogenesis
    Stanley E. Lazic, Johannes Fuß, Peter Gass · 2014 · arXiv (Cornell University)
  41. Faculty Opinions recommendation of Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis.
    Paul W. Farquhar-Smith, Richard Gordon-Williams · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  42. Future of Regulatory Safety Assessments
    Gerd Bode, Petra Starck-Lantova · 2018 · Springer eBooks
  43. Faculty Opinions recommendation of Are all stem cells equal? Systematic review, evidence map, and meta-analyses of preclinical stem cell-based therapies for bronchopulmonary dysplasia.
    Vineet Bhandari · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  44. Letter to the Editor
    Ray Greek · 2014 · Metamedicine
  45. Full Issue PDF
    2020 · Advances in Pulmonary Hypertension
  46. Evaluating publication bias for clinical trials supporting new dermatologic drug approvals from 2003 to 2018
    Sairekha Ravichandran, Kathleen M. Mulligan, Harib H. Ezaldein, Jeffrey F. Scott · 2022 · Archives of Dermatological Research
  47. Recommended resources and online material for investigating neurological disorders and the use of animal models
    Rajkumar Rajendram, Vinood B. Patel, Daniel Gyamfi, Victor R. Preedy · 2022 · Elsevier eBooks
  48. Mouse Models of Ischemia
    David Clifford Henshall, Roger Pancoast Simon · 2011 · Royal Society of Chemistry eBooks
  49. Selection of animal models for drug efficacy
    Désirée H. Veening-Griffioen · 2023
  50. Critique
    Bradley Kenneth Weiner · 2023 · Springer eBooks
  51. Sample Size and Hypothesis Testing
    Penny S. Reynolds · 2023
  52. The Sample Size Problem in Animal‐Based Research
    Penny S. Reynolds · 2023 · Wiley eBooks
  53. Silk protein: an emerging biomaterial for tumor modeling
    Tuli Dey, Sarmistha Talukdar, Sukanya Gayan, Subhas Chandra Kundu · 2024 · Elsevier eBooks
  54. Estimating attrition of Sprague Dawley rats for the establishment of an oxygen-glucose deprivation model
    Rolando A. Gittens, Bernardino Denis, Rosa De Jesús · 2024 · Research Square
  55. Reporting of Animal Research Studies in Concordance with ARRIVE Guidelines in Indian Medical Journals
    Kavita Sawachia, Shubha Singhal, Ankita Mishra, Bhupinder Singh Kalra · 2021 · MAMC Journal of Medical Sciences
  56. Effect-Size Discrepancies in Literature Versus Raw Datasets from Experimental Spinal Cord Injury Studies: A CLIMBER Meta-Analysis
    Emma Iorio, Alireza Khanteymoori, Kenneth A. Fond, Anastasia Keller, Lex Maliga Davis, Jan Markus Schwab, Adam R. Ferguson, Abel Torres Espin, Ralf Watzlawick · 2024 · Neurotrauma Reports
  57. Scope Validity in Medicine: An Asset to the Epidemiologist’s Armoury
    Frank J. Wolters · 2024 · Philosophy and medicine
  58. Future of Regulatory Safety Assessment
    Gerd Bode, Petra Starck-Lantova, Peter-Juergen Kramer · 2024 · Springer eBooks
  59. Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis
    Spyridon Siafis, Nobuyuki Nomura, Johannes Schneider‐Thoma, Irene Bighelli, Alexandra Bannach‐Brown, Fiona Ramage, Francesca Tinsdeall, Ioannis Mantas, Sameer Jauhar, Sridhar Natesan et al. · 2025 · F1000Research
  60. CCR5 antagonists as neuroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis
    Ayni Sharif, Matthew Strider Jeffers, Dean A. Fergusson, Raj Bapuji, Stuart Gordon Nicholls, John Humphrey, Warren Johnston, Ed Mitchell, Mary-Ann Speirs, Laura Stronghill et al. · 2025 · eLife
  61. Arzneimittelanwendungen außerhalb oder vor der offiziellen Zulassung: ethische Herausforderungen von Off-Label-Use, Compassionate Use und individuellen Heilversuchen
    Holger Langhof, Daniel Strech · 2024 · Springer eBooks
  62. CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents: a preclinical systematic review and meta-analysis
    Ayni Sharif, Matthew Strider Jeffers, Dean A. Fergusson, Raj Bapuji, Stuart Gordon Nicholls, John Humphrey, Warren Johnston, Ed Mitchell, Mary-Ann Speirs, Laura Stronghill et al. · 2025 · eLife
  63. In reply to the letter to the editor regarding “Bayesian evaluation of phage therapy efficacy against multidrug-resistant Acinetobacter Baumannii”
    Momna Arooj Malik, Sobia Manzoor, Javed Ashraf · 2025 · International Journal of Antimicrobial Agents
  64. Incorporating farm animal models for the study of neuropsychiatric diseases: Expansion of the possibilities
    Alexandra K Dwulit, Rajendra A. Morey, F. Josef van der Staay · 2025 · Cognitive Affective & Behavioral Neuroscience
  65. Volumetric MRI and FDG-PET hypometabolism biomarkers of frontotemporal dementia: protocol for a systematic review and meta-analysis
    Taylor J Solomon, Ana Antonic‐Baker, Lorena Romero, Benjamin Sinclair, Terence John O'Brien, Lucy E. Vivash · 2025 · BMJ Open
  66. Additional file 3 of Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol
    M. Laflamme, Hourmazd Haghbayan, Lalu, Manoj M., Zarychanski, Ryan, François Lauzier, Amélie Boutin, Macleod, Malcolm R., Dean A. Fergusson, Moore, Lynne, Olivier Costerousse et al. · 2021 · Figshare
  67. Additional file 1 of Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol
    M. Laflamme, Hourmazd Haghbayan, Lalu, Manoj M., Zarychanski, Ryan, François Lauzier, Boutin, Amélie, Macleod, Malcolm R., Dean A. Fergusson, Moore, Lynne, Olivier Costerousse et al. · 2021 · Figshare
  68. Additional file 1 of Meta-analysis of preclinical measures of efficacy in immune checkpoint blockade therapies and comparison to clinical efficacy estimates
    Juan Miguel Tenorio-Pedraza, Jörg Lippert, Rolf Burghaus, Christian Scheerans · 2023 · Figshare
  69. Additional file 2 of Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol
    M. Laflamme, Hourmazd Haghbayan, Lalu, Manoj M., Zarychanski, Ryan, François Lauzier, Boutin, Amélie, Macleod, Malcolm R., Dean A. Fergusson, Moore, Lynne, Olivier Costerousse et al. · 2021 · Figshare
  70. Can cell-based therapies bridge the gap between research and reality in the treatment of myocarditis? A systematic review and meta-analysis
    U. Yakhshimurodov, K. Yamashita, S. Komukai, B. Isomitdinov, Takuji Kawamura, S. Saito, Shigeru Miyagawa · 2026 · Regenerative Therapy
  71. Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study
    Carolyne Jie Huang, Samuel Pawel, Kimberley Elaine Wever, Benjamin Victor Ineichen, Rachel Heyard · 2026 · eLife
  72. Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study
    Carolyne Jie Huang, Samuel Pawel, Kimberley Elaine Wever, Benjamin Victor Ineichen, Rachel Heyard · 2026 · eLife
  73. Effect of adhesive removal methods on the shear bond strength of reconditioned orthodontic brackets: An updated systematic review and meta-analysis of in vitro studies
    Jamal Jabr, Nadia Bahlouli, Hamdi Jmal, Nicolas Nassar, Ahmed A. Holiel, Roland Kmeid, Rim Bourgi, Naji Kharouf · 2026 · International Journal of Adhesion and Adhesives
  74. A call for preregistration of in vitro research
    Céline Heinl, Nuno Henrique Franco, Bettina Bert, Katherina Siewert, Dania Movia, Edlira Aruçi, Carina Ladeira, Ahmed Y. Sanin, Winfried Neuhaus, Ulf D. Kahlert et al. · 2026 · EMBO Reports
  75. Stroke-Related Animal Models: Methodologies, Applications, and Translational Perspectives
    Chenglong Shi, Mengyuan Xu, Yanmei Li, Lei Zhao, Haitao Xu, Lei Xian, Zhenyu Wang, Longjie Qin, Xiao‐Li Min · 2026 · Journal of Visualized Experiments
  76. Neuroprotective Agents for Photoreceptor Rescue Following Experimental Retinal Detachment in Rodents: A Systematic Review
    Konstantinos G Baroutis, Dimitris Baroutis, Ioanna Ploumi, Maria Anna Bantounou, Maria Emfietzoglou, Irini Chatziralli, Ilias Georgalas, Panagiotis Theodossiadis, Joan W. Miller, Demetrios G. Vavvas · 2026 · Investigative Ophthalmology & Visual Science
  77. Beneficial effects of the novel first-in-class compound DX243 on ischemic outcomes following in vitro and in vivo models of stroke
    Quentin Marlier, Alexia Boreux, Arnaud Rives, Dario Mosca, Helene Michaux, Louisa Schmitz, P Attali, Stephane Silvente, Philippe Pierre Lefebvre, Brigitte Malgrange et al. · 2026 · Frontiers in Stroke
  78. Glucagon-like Peptide-1 Receptor Agonists as Modulators of Pain-Related Mechanisms: A Systematic Review of Experimental and Translational Evidence
    Sebastián Eustaquio Martín Pérez, Isidro Miguel Martín Pérez · 2026 · Rheumato
  79. A robust and reproducible automated MRI pipeline for quantifying tissue outcomes after experimental stroke in multi-center preclinical networks
    Kirsten M. Lynch, Ryan P. Cabeen, Andreia Morais, Xuyan Jin, Erendiz Tarakci, Jessica Lamb, Basavaraju G. Sanganahalli, Jelena M. Mihailović, Yamileck Olivas-Garcia, David B. Berry et al. · 2026 · Imaging Neuroscience
  80. Reporting and transparency in laboratory animal science: Past achievements, present concerns and future directions
    Penny S. Reynolds, Esther J. Pearl · 2026 · Laboratory Animals
  81. Effects of curcumin on inflammatory and oxidative stress related markers in rat models of experimental arthritis: a systematic review and meta-analysis
    Hongxiang Duan, Ying Liu, Kantapich Kongpol, Anuchit Phanumartwiwath · 2026 · Inflammopharmacology
  82. From pathology to network failure: a Question–Model–Outcome framework for interpreting animal models of AD-related and dementia-relevant mechanisms
    Umut Şimşekçi, Yıldırım Cesaretli · 2026 · Frontiers in Aging Neuroscience
  83. Effects of Naringenin on Diabetic Nephropathy: A Systematic Review and Meta‐Analysis of Rodent Studies
    Yuzhu Qu, Jie Chen, Ling Yue, Xinyue Zhang, Kongmei Ou, Yiting Wang, Runjia He, Benxiang He · 2026 · Food Science & Nutrition
  84. Genetic and pharmacological modulation of metabotropic glutamate receptors and cognition in animal models: A systematic review
    Sunjun Huh, Kohei Yamada, Saki Homma, Takahide Etani, Ryoma Kani, Tony Kaku, Keisuke Saito, Amaki Tsukazaki, Takanori Saka, Ayuka Takase et al. · 2026 · Research Square
  85. Therapeutic Potential of Allicin in Multi-System Inflammatory Diseases
    Jieyou Zhao, Jiawen Zhao, Zhaoyang Li, Nana Cheng, Chenhao Feng, Yunjia Song, Xütao Sun · 2026 · Current Issues in Molecular Biology
  86. Neuroprotective effects and mechanistic insights of sinomenine in ischemic stroke: a systematic review and meta-analysis of preclinical animal studies
    Xiaoqun Li, Lulu Wen, Yun Du, Xinzuo Qin, Junyi Zhou, Ningyu Xue, Xinyue Fan, Haiyu Zhao, Miao Qu · 2026 · Frontiers in Pharmacology
  87. Multilaboratory, Blinded, Randomized Trial of Five Cerebroprotectants in Ischemic Stroke
    Cenk Ayata, Anil Kumar Chauhan, David Charles Hess, Bingren R. Hu, Enrique C. C Leira, Lauren Hachmann Sansing, Huaxin Sheng, Takahiko Imai, Xuyan Jin, Sanem A Aykan et al. · 2026 · Circulation Research
  88. Allele-Stratified Activity of RAS Inhibitors in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Exploratory Meta-Analysis
    Munahil Muhammad, Aisha Al Khinji, Mayasa Al-Ansari, Najlaa Al-Marri, Shahad Al-Shaheen, Dhafer Malouche · 2026 · Cancers
  89. Efficacy and neuroprotective effects of tetramethylpyrazine in animal models of spinal cord injury: a systematic review, meta-analysis, and exploratory machine-learning study
    Shaocong Li, Sichong Qiu, Qiqi Tang, Junxiao Ren, Zewei Zhao, Xiangjin Wang, Xiaohong Fan · 2026 · Frontiers in Pharmacology
  90. The validity and translatability of preclinical animal research
    Pandora Pound · 2026 · Elsevier eBooks
  91. Safety within REACH? a transition analysis for the European Commission roadmap to animal-free safety assessment of industrial chemicals
    Love Hansell, L. Bastos, Kelsey Beltz, Merel J. Ritskes-Hoitinga, Thomas Härtung, Julia Pochat, Anne van der Veen, I.J. Visseren-Hamakers, Justine Watkins, Howard White · 2026 · Elsevier eBooks
  92. Pitfalls, common errors, and false interpretation
    Mohammed Gumaa, David I. Lewis, Menha Swellam · 2026 · Elsevier eBooks
  93. Antidepressant effects of artemisinin and its derivatives: a systematic review and meta-analysis of randomized controlled animal studies
    Yuan Tian, Haiping Zhang, Xu Zhang, Luyao Wang · 2026 · Frontiers in Pharmacology
  94. Polyethylene Microplastics and Cardiometabolic Mitochondrial-Redox Dysfunction in Preclinical Rodent Models: A Systematic Review and Meta-Analysis of Bioenergetic and Oxidative Stress Outcomes Across Target Organs
    Samuel Abiodun Kehinde, Wai Phyo Lin, Pinanong Na-Phatthalung, Siriwan Kantisin, Saira Naz, Mariana Teles, Sasitorn Chusri · 2026 · Cardiovascular Toxicology
  95. Marine-Derived Natural Compounds in Respiratory Diseases: A Systematic Review of Preclinical Mechanisms, Clinical Evidence, and Translational Gaps
    Valentina Lazzara, Andrea Perri, Alessandra Pandolfo, Paola Pinto, Giustino Carlino, Stefania La Grutta, Elisabetta Pace, Giusy Daniela Albano, Velia Malizia · 2026 · Marine Drugs
  96. Molecular Targeting of the Peripheral Nerve–Tumor Axis in Extracranial Solid Cancers: Eight Signaling Systems, One Effect—Systematic Review and Multilevel Meta-Analysis
    Diana Rodica Tudoraşcu, Cristin Constantin Vere, Mihai Petrescu, Ana-Maria Ciurea, Razvan Cosmin Pana, Alexandra Oltea Dan, Elena Anca Târtea, Andrei Greșiță, Diana-Ruxandra Hădăreanu, Cosmin Vasile Obleagă et al. · 2026 · International Journal of Molecular Sciences
  97. From worms to therapeutics: Helminth-derived immunomodulatory proteins and peptides as potential therapeutics for inflammatory diseases
    Hatem A. Elshabrawy, Hossam M. Ashour · 2026 · Molecular Therapy
  98. NRF2 signalling in environmental metal and metalloid neurotoxicity: distinguishing stress responses from functional neuroprotection
    Bolaji Samuel Mesole, Uthman Ademola Yusuf, Alfred Omachonu Okpanachi, Rademene Sunday Oria, Flavien Nsoni Bumbangi · 2026 · Frontiers in Toxicology