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Cited by 156Neural dynamics and brain functionPhysiological and biochemical adaptationsNeurobiology and Insect Physiology Research

Precise temperature compensation of phase in a rhythmic motor pattern

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Tang, Lamont S., Goeritz, Marie L., Caplan, Jonathan S., Taylor, Adam L., Fisek, Mehmet, Marder, Eve·2010·PLoS Biology
DOI 10.1371/journal.pbio.1000469PMC PMC2930868
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Abstract

Most animal species are cold-blooded, and their neuronal circuits must maintain function despite environmental temperature fluctuations. The central pattern generating circuits that produce rhythmic motor patterns depend on the orderly activation of circuit neurons. We describe the effects of temperature on the pyloric rhythm of the stomatogastric ganglion of the crab, Cancer borealis. The pyloric rhythm is a triphasic motor pattern in which the Pyloric Dilator (PD), Lateral Pyloric (LP), and Pyloric (PY) neurons fire in a repeating sequence. While the frequency of the pyloric rhythm increased about 4-fold (Q(10) approximately 2.3) as the temperature was shifted from 7 degrees C to 23 degrees C, the phase relationships of the PD, LP, and PY neurons showed almost perfect temperature compensation. The Q(10)'s of the input conductance, synaptic currents, transient outward current (I(A)), and the hyperpolarization-activated inward current (I(h)), all of which help determine the phase of LP neuron activity, ranged from 1.8 to 4. We studied the effects of temperature in >1,000 computational models (with different sets of maximal conductances) of a bursting neuron and the LP neuron. Many bursting models failed to monotonically increase in frequency as temperature increased. Temperature compensation of LP neuron phase was facilitated when model neurons' currents had Q(10)'s close to 2. Together, these data indicate that although diverse sets of maximal conductances may be found in identified neurons across animals, there may be strong evolutionary pressure to restrict the Q(10)'s of the processes that contribute to temperature compensation of neuronal circuits.

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  • In initial studies of the effects of temperature on the pyloric rhythm of crabs, the rhythm increased in frequency in a permissive range, but then crashed or lost function at temperatures above 25-28°C.

    “In our initial studies of the effects of temperature on the pyloric rhythm of crabs, we found that the rhythm increased in frequency in a permissive range, but then 'crashed' or lost function at temperatures above 25-28 • C [41, 65,66].”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [41]

    The Results section, “Effects of Temperature on the Pyloric Rhythm” (page unavailable), reports that the crab pyloric rhythm increased about fourfold in frequency as temperature rose from 7°C to 23°C. It does not report a crash or loss of function above 25–28°C; the biological recordings described here stop at 23°C. (LLM, conf=0.88)

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Authors
Tang, L. S., Goeritz, M. L., Caplan, J. S., Taylor, A. L., Fisek, M., & Marder, E.
Affiliations
Brandeis University (US)
Corresponding author
Marder, Eve
ORCID
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2010-08-31
Volume
8
Issue
8
Pages
e1000469
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.1000469
PMC
PMC2930868
OpenAlex
W1985995409
Cited by
156
References
1
Citations by year
2026: 8 · 2025: 10 · 2024: 22 · 2023: 11 · 2022: 16 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 12 · 2014: 14 · 2013: 7 · 2012: 6
FWCI
3.70
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Brandeis Institutional Repository (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (5p01ns044232-10)
  • National Institute of Mental Health (MH 46742, R37MH046742, R01MH046742)
  • National Institute of Neurological Disorders and Stroke (P01 NS-044232, 2P01 NS-044232)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
temperature compensation, pyloric rhythm, stomatogastric ganglion, Cancer borealis, central pattern generator, Q10, pyloric dilator neuron, lateral pyloric neuron, maximal conductance, ectotherms
MeSH terms
Animals, Brachyura, Motor Activity, Motor Neurons, Synaptic Transmission, Periodicity, Pylorus, Temperature, Ganglia, Invertebrate

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