Functional segregation of cortical regions underlying speech timing and articulation
Open accessAbstract
Spoken language is a central part of our everyday lives, but the precise roles that individual cortical regions play in the production of speech are often poorly understood. To address this issue, we focally lowered the temperature of distinct cortical regions in awake neurosurgical patients, and we relate this perturbation to changes in produced speech sequences. Using this method, we confirm that speech is highly lateralized, with the vast majority of behavioral effects seen on the left hemisphere. We then use this approach to demonstrate a clear functional dissociation between nearby cortical speech sites. Focal cooling of pars triangularis/pars opercularis (Broca's region) and the ventral portion of the precentral gyrus (speech motor cortex) resulted in the manipulation of speech timing and articulation, respectively. Our results support a class of models that have proposed distinct processing centers underlying motor sequencing and execution for speech.
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Broca's area plays a role in normal speech production.
“We do not question the role that Broca’s area has been shown to play in normal speech production”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Long et al., 2016
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- Authors
- Long, M. A., Katlowitz, K. A., Svirsky, M. A., Clary, R. C., Byun, T. M., Majaj, N., Oya, H., Howard, M. A., & Greenlee, J. D. W.
- Affiliations
- NYU Langone Health (US)
- New York University (US)
- University of Iowa (US)
- Corresponding author
- Long, Michael A.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 89
- Issue
- 6
- Pages
- 1187-1193
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4833207
- OpenAlex
- W2278011264
- Cited by
- 151
- References
- 59
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 19 · 2023: 12 · 2022: 16 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 7
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC015260, K23DC009589, DC009589, DC004290, R01DC004290)
- National Institute of Neurological Disorders and Stroke (NS075044, R56NS075044, R01NS075044)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- speech production, speech timing, articulation, cortical lateralization, Broca's area, precentral gyrus, functional segregation, motor sequencing, speech motor control
- MeSH terms
- Adult, Aged, Biophysics, Brain Mapping, Brain Neoplasms, Cold Temperature, Electric Stimulation, Epilepsy, Female, Humans, Functional Laterality, Male, Middle Aged, Motor Cortex, Sound Spectrography, Speech, Speech Articulation Tests, Time Factors, Wakefulness, Broca Area
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