Evaluation of excess significance bias in animal studies of neurological diseases
Tsilidis, Konstantinos K., Panagiotou, Orestis A., Sena, Emily S., Aretouli, Eleni, Evangelou, Evangelos, Howells, David W., Salman, Rustam Al-Shahi, Macleod, Malcolm R. +1 more·2013·PLoS Biology
Cited by (295)
Items 201–295 of 295
- Reproducibility in Biomedical ResearchKevin Mullane, Michael J. Curtis, Michael J. Williams · 2017 · Elsevier eBooks
- Association between apical periodontitis and brain inflammation: a systematic review from animals and human studiesJulia da Conceição Francisquini, Luan Felipe Toro, Renato Gomes Azevedo, Gestter Willian Lattari Tessarin · 2025 · Odontology
- Persistent organic pollutants: Neurotoxic mechanisms and insights from organoid modelsZiyu Ji, Liqun Chen, Dong Ming · 2026 · Toxicology
- Therapeutic interventions for childhood cancer: An umbrella review of randomized evidenceGeorgios Lavasidis, Georgios Markozannes, Orestis A. Panagiotou, Nikolaos A. Trikalinos, Eleni Th. Petridou, Kirsten R. Voorhies, Evangelia Ntzani · 2021 · Critical Reviews in Oncology/Hematology
- How to End Selective Reporting in Animal ResearchGerben ter Riet, L.M. Bouter · 2016 · Methods and principles in medicinal chemistry
- Reproducibility crisis, the scientific method, and the quality of published studies: Untangling the knotThiago F. A. França, José María Monserrat · 2019 · Learned Publishing
- Animal Models and the Search for Drug Treatments for Traumatic Brain InjuryPandora Pound · 2020 · Advances in neuroethics
- Families’ experiences with medical research for pediatric rare diseases : a qualitative ethnographic study of parents and children participating in clinical trials for Duchenne muscular dystrophy (DMD)Christopher J. Condin · 2014 · cIRcle (University of British Columbia)
- Challenges of Conducting Risk‐Benefit Analysis of Early Phase Clinical Trials: Results of a National Survey of IRB ChairsChristine M. Baugh, Dragana Bolcic‐Jankovic, Mark Fedyk, Mark A. Yarborough, Spencer Phillips Hey, Insoo Hyun, Jonathan Kimmelman, Eric G. Campbell · 2025 · Ethics & Human Research
- Connecting the dots in neuroscience research: The future of evidence synthesisKaitlyn Hair, María Arroyo-Araujo, Sofija Vojvodić, Maria Economou, Charis Wong, Francesca Tinsdeall, Sean Smith, Torsten Rackoll, Emily S. Sena, Sarah McCann · 2024 · Experimental Neurology
- Reporting preclinical gene therapy studies in the field of Niemann-Pick type C disease according to the ARRIVE guidelinesCharlotte Laurfelt Munch Rasmussen, Annette Burkhart, Torben Moos, Louiza Bohn Thomsen · 2025 · Orphanet Journal of Rare Diseases
- Neglecting the null: the pitfalls of underreporting negative results in preclinical researchWilliam Foster, Samantha Putos · 2014 · University of Ottawa Journal of Medicine
- Are there relevant animal models to set research priorities in LUTD? ICI‐RS 2019Karl‐Erik Andersson, Lori Ann Birder, Christopher Chermansky, Russ Chess‐Williams, Christopher Henry Fry · 2020 · Neurourology and Urodynamics
- Supportive interventions for childhood cancer: An umbrella review of randomized evidenceGeorgios Lavasidis, Georgios Markozannes, Kirsten R. Voorhies, Nikolaos A. Trikalinos, Eleni Th. Petridou, Orestis A. Panagiotou, Evangelia Ntzani · 2022 · Critical Reviews in Oncology/Hematology
- Future of Regulatory Safety AssessmentGerd Bode, Petra Starck-Lantova, Peter-Juergen Kramer · 2023 · Springer eBooks
- Neural Enhancement for Independent LivingRichard G. Carson · 2015 · Journal of Motor Behavior
- Bad Science: Cause and ConsequenceSteve Elliott · 2016 · Journal of Pharmaceutical Sciences
- Animal studies produce many false positivesHeidi K. Ledford · 2013 · Nature
- A survey of researchers’ attitudes to preregistration in animal research reveals multiple perceived barriers to adoptionCristina Priboi, Boris Mayer, Evie Vergauwe, Bernice S. Elger, Hanno Würbel · 2026 · PLoS Biology
- La experimentación animal y el progreso de la medicinaJoan M.V. Pons, Gaietà Permanyer-Miralda, Jordi Camı́, Joan Rodés · 2014 · Medicina Clínica
- Data sharing and re‐use as a moral imperative in animal researchI. Bjerke · 2024 · European Journal of Neuroscience
- The effects of cinnamon on patients with metabolic diseases: an umbrella review of meta-analyses of randomized controlled trialsHaobo Gou, Ling Zhong, Qiuya Wei, Yong Fan · 2025 · Frontiers in Nutrition
- Long non-coding RNAs for osteosarcoma in the mouse: a meta-analysisShaopu Hu, Junli Chang, Yimian Li, Wenyi Wang, Edward C. Zou, Mengyao Guo, Qi Wu Shi, Yongjun Wang, Yanping Yang · 2017 · Oncotarget
- Preclinical Research: A Rise or DawnSadananda Rao Manjunath · 2018 · Pharmacy & Pharmacology International Journal
- Amyloid in the ageing brain: New frameworks and perspectivesSally Hunter, Carol Brayne · 2021 · Aging Brain
- Discovery reliabilityA. Hånell · 2019 · Journal of Cerebral Blood Flow and Metabolism
- Researchers‘ perspectives on preregistration in animal researchCristina Priboi, Boris Mayer, Evie Vergauwe, Bernice S. Elger, Hanno Würbel · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- A Systematic Assessment of Drug Repurposing Efforts Against COVID‐19: Limited Successes and Key ChallengesAndreas Riedel, Peter Ruth, Markus W. Loeffler, Nicolai Stransky · 2025 · Journal of Clinical Pharmacy and Therapeutics
- Prof Benchie and Dr Athena—A modern tragedy…Malcolm Robert Macleod · 2015 · Evidence-based Preclinical Medicine
- Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for StrokeS. McCann, E. Sena, G. Currie, M. Macleod, D. Howells · 2017 · Springer series in translational stroke research
- Potenziale und Grenzen des EBM-Paradigmas in den GesundheitswissenschaftenMartin Langanke, Stefan Kirschke · 2017 · Springer eBooks
- Future of Regulatory Safety AssessmentsGerd Bode, Petra Starck-Lantova · 2020 · Springer eBooks
- How to Avoid Bumping into the Translational RoadblockMalcolm Robert Macleod, Emily S. Sena · 2016 · Neuromethods
- Publication BiasR. Barker Bausell · 2021
- Association of Animal Models in the Field of Translational Medicine: Prediction and ValidationDebora Bizzaro · 2022 · Handbook of Animal Models and its Uses in Cancer Research
- Threats to Benefits: Assessing Knowledge Production in Nonhuman Models of Human Neuropsychiatric DisordersCarolyn P. Neuhaus · 2022 · The Hastings Center Report
- Association of Animal Models in the Field of Translational Medicine: Prediction and ValidationDebora Bizzaro · 2023 · Handbook of Animal Models and its Uses in Cancer Research
- The structure of non-human cognitive neuroscience: an epistemological critiqueFrancisco Almeida · 2019 · Reviews in the Neurosciences
- Neurological, Psychiatric, and Psychological Implications of the COVID-19 Pandemic: Protocol for a Large-Scale Umbrella Review of Observational StudiesTa‐Chuan Yeh, Chih‐Sung Liang, Chia‐Kuang Tsai, Marco Solmi, Beny Lafer, Ping‐Tao Tseng, Chih‐Wei Hsu, Pao‐Yen Lin, Joseph Firth, Brendon Stubbs et al. · 2022 · International Journal of Environmental Research and Public Health
- Meta‐analysis of the effects of anti‐migraine therapeutics in the rat trigeminovascular nociception model as a tool for design optimizationA. Dolgorukova, E. Protsenko, J. Isaeva, Victoria Gagloeva, E. Verbitskaya, R. Berkovich, A. Sokolov · 2023 · European Journal of Neuroscience
- The Solution to Science's Replication CrisisBruce Knuteson · 2016 · SSRN Electronic Journal
- Researcher Conduct Determines Data ReliabilityMark N. Wass, Larry Ray, Martin Michaelis · 2018 · Preprints.org
- Economically rational sample-size choice and irreproducibility.Oliver Braganza · 2019 · arXiv (Cornell University)
- Author response: Four erroneous beliefs thwarting more trustworthy researchMark A. Yarborough, Robert Nadon, David Karlin · 2019 · eLife
- Valid statistical approaches for clustered data: A Monte Carlo simulation studyKristen A. McLaurin, Amanda Jane Fairchild, Dexin Shi, Rosemarie M. Booze, Charles F. Mactutus · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Faculty Opinions recommendation of No raw data, no science: another possible source of the reproducibility crisis.Wladek Minor, David R. Cooper · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- A dynamic balance between neuronal death and clearance after acute brain injuryTrevor Balena, Kyle P. Lillis, Negah Rahmati, Fatemeh Bahari, Volodymyr I. Dzhala, Eugene Berdichevsky, Kevin J. Staley · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Research in Laboratory Animal and Comparative MedicineJ. Mark Cline, Thomas B. Clarkson · 2015 · Elsevier eBooks
- Counterproductive biasMonica Hoyos Flight · 2013 · Nature reviews. Neuroscience
- A (mini) pill for stroke?Malcolm Robert Macleod · 2014 · Brain
- Why Is There a Disparity in Reporting Preclinical Studies?Tom Valeo · 2014 · Neurology Today
- Is animal research sufficiently evidence based to be a cornerstone of biomedical research? Public acceptance of the use of animals in biomedical research is conditional on it producing benefits for humans. Pandora Pound and Michael Bracken argue that the benefits remain unproved and may divert funds from research that is more relevant to doctors and their patientsPandora Pound · 2014
- SHIGEYUKI MATSUI, MARC BUYSE, RICHARD SIMON, EDS. Design and Analysis of Clinical Trials for Predictive Medicine. Boca Raton: CRC PressOrestis A. Panagiotou · 2017 · Biometrics
- Practical statistical considerations for investigating anti-tumor treatments in miceDavid Lee Gold, Lixin Lang, Kim E. Zerba · 2018 · Journal of Applied Statistics
- Future of Regulatory Safety AssessmentsGerd Bode, Petra Starck-Lantova · 2018 · Springer eBooks
- Decision letter: Four erroneous beliefs thwarting more trustworthy research2019 · eLife
- What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regressionH. Hunter, D. de Gracia Hahn, Amedine Duret, Y. Im, Q. Cheah, Jiawen Dong, M. Fairey, Clarissa Hjalmarsson, Alice Li, Hong Lim et al. · 2019 · bioRxiv
- Evaluation of a Meta-Analysis of Ambient Air Quality as a Risk Factor for Asthma ExacerbationWarren B. Kindzierski, S. Stanley Young, Terry G. Meyer, John Dale Dunn · 2021 · Journal of Respiration
- The Solution to Science's Replication CrisisBruce Knuteson · 2016 · RePEc: Research Papers in Economics
- Reproducibility Crisis in Science: A Discussion of the Disregard of ARRIVE Guidelines and Other Shortfalls of Pre-Clinical Research ReportingChristopher Knox · 2020 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Leaps of logic: quantifying the behavioural relevance of hippocampal neurogenesisStanley E. Lazic, Johannes Fuß, Peter Gass · 2014 · arXiv (Cornell University)
- Future of Regulatory Safety AssessmentsGerd Bode, Petra Starck-Lantova · 2018 · Springer eBooks
- Faculty Opinions recommendation of No raw data, no science: another possible source of the reproducibility crisis.Jean‐Louis Mergny · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- NotesFran Quigley · 2018 · Cornell University Press eBooks
- Meta-analysis of the effects of clinically-effective therapeutics in the preclinical migraine model as a tool for design optimisationAntonina Dolgorukova, Ekaterina Protsenko, Julia Isaeva, Victoria Gagloeva, Elena V. Verbitskaya, Alexey Y. Sokolov · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- CritiqueBradley Kenneth Weiner · 2023 · Springer eBooks
- Friendship2023 · Duke University Press eBooks
- Postscript2023 · Duke University Press eBooks
- Solicitude2023 · Duke University Press eBooks
- Scrupulousness2023 · Duke University Press eBooks
- Poem-Like Tolls 12023 · Duke University Press eBooks
- Works Cited2023 · Duke University Press eBooks
- Poem-Like Tolls 32023 · Duke University Press eBooks
- Double Binds of Science2023 · Duke University Press eBooks
- Curation2023 · Duke University Press eBooks
- Fors2023 · Duke University Press eBooks
- Labyrinth Life2023 · Duke University Press eBooks
- Poem-Like Tolls 22023 · Duke University Press eBooks
- Notes2023 · Duke University Press eBooks
- Agreement of farm animal behaviour and welfare studies with the ARRIVE Essential 10J. Calderón-Amor, D. Luna, T. Tadich · 2023 · Research Ethics
- Effect-Size Discrepancies in Literature Versus Raw Datasets from Experimental Spinal Cord Injury Studies: A CLIMBER Meta-AnalysisEmma Iorio, Alireza Khanteymoori, Kenneth A. Fond, Anastasia Keller, Lex Maliga Davis, Jan Markus Schwab, Adam R. Ferguson, Abel Torres Espin, Ralf Watzlawick · 2024 · Neurotrauma Reports
- Future of Regulatory Safety AssessmentGerd Bode, Petra Starck-Lantova, Peter-Juergen Kramer · 2024 · Springer eBooks
- Why too much biomedical research is often undeserving of the public’s trustMark A. Yarborough · 2025 · Frontiers in Genetics
- Data CollectionDavid Kaplan · 2025 · Springer eBooks
- Additional file 1 of Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviewsMentis, Alexios-Fotios A., Efthimios Dardiotis, Vasiliki Efthymiou, Chrousos, George P. · 2021 · Figshare
- Additional file 2 of Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviewsMentis, Alexios-Fotios A., Efthimios Dardiotis, Vasiliki Efthymiou, Chrousos, George P. · 2021 · Figshare
- Additional file 1 of Homelessness and health-related outcomes: an umbrella review of observational studies and randomized controlled trialsFornaro, Michele, Elena Dragioti, De Prisco, Michele, Martina Billeci, Anna Maria Mondin, Raffaella Calati, Lee Smith, Simon Hatcher, Mark Kaluzienski, Jess G. Fiedorowicz et al. · 2022 · Figshare
- Additional file 3 of Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviewsMentis, Alexios-Fotios A., Efthimios Dardiotis, Vasiliki Efthymiou, Chrousos, George P. · 2021 · Figshare
- Identifying risk factors of young-onset dementia and evaluating evidence hierarchy: a meta-analysis and umbrella reviewJiayu Zhang, Dandan Yang, Jian Liang, Yin Hu, Liping Rao, Jun Huang, Qijun Wu, Bo Jiang · 2026 · The Journal of Prevention of Alzheimer s Disease
- The role of sex hormones in neurological and functional recovery following spinal cord injury in females: a systematic review of the literatureEma Vidaković, Elisabeth Bamberg, Björn Zörner, Kathleen Ostheim, Beatrice Minder, Sue Bertschy, Juergen Pannek, Petra Stute, Marija Glisic · 2026 · Spinal Cord
- Neuroprotective Agents for Photoreceptor Rescue Following Experimental Retinal Detachment in Rodents: A Systematic ReviewKonstantinos G Baroutis, Dimitris Baroutis, Ioanna Ploumi, Maria Anna Bantounou, Maria Emfietzoglou, Irini Chatziralli, Ilias Georgalas, Panagiotis Theodossiadis, Joan W. Miller, Demetrios G. Vavvas · 2026 · Investigative Ophthalmology & Visual Science
- Effects of curcumin on inflammatory and oxidative stress related markers in rat models of experimental arthritis: a systematic review and meta-analysisHongxiang Duan, Ying Liu, Kantapich Kongpol, Anuchit Phanumartwiwath · 2026 · Inflammopharmacology
- The validity and translatability of preclinical animal researchPandora Pound · 2026 · Elsevier eBooks
- Safety within REACH? a transition analysis for the European Commission roadmap to animal-free safety assessment of industrial chemicalsLove Hansell, L. Bastos, Kelsey Beltz, Merel J. Ritskes-Hoitinga, Thomas Härtung, Julia Pochat, Anne van der Veen, I.J. Visseren-Hamakers, Justine Watkins, Howard White · 2026 · Elsevier eBooks
- Untitled work2015 · PubMed Central