The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
X Chromosome Reactivation Initiates in Nascent Primordial Germ Cells in Mice
Open accessAbstract
During primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X reactivation is thought to take place over a short period of time just before initiation of meiosis. Here, we show that the cessation of Xist expression commences in nascent PGCs, and re-expression of some X-linked genes begins in newly formed PGCs. The X reactivation process was not complete in E14.5 PGCs, indicating that X reactivation in developing PGCs occurs over a prolonged period. These results set the reactivation timing much earlier than previously thought and suggest that X reactivation may involve slow passive steps.
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Citations
Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Cited by
The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells
Seisenberger, S., Andrews, S., Krueger, F., Arand, J., Walter, J., Santos, F., Popp, C., Thienpont, B., Dean, W., & Reik, W. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.001 · Cited by 973
Epigenetic events in mammalian germ-cell development: reprogramming and beyond
Sasaki, H., & Matsui, Y. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2295 · Cited by 871
A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development
Tang, W. W. C., Dietmann, S., Irie, N., Leitch, H. G., Floros, V. I., Bradshaw, C. R., Hackett, J. A., Chinnery, P. F., & Surani, M. A. (2015) · Cell · doi:10.1016/j.cell.2015.04.053 · Cited by 670
Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells
Saitou, M., Kagiwada, S., & Kurimoto, K. (2012) · Development · doi:10.1242/dev.050849 · Cited by 414
Epigenetic reprogramming in mice and humans: From fertilization to primordial germ cell development
Singh, A., Rappolee, D. A., & Ruden, D. M. (2023) · Cells · doi:10.3390/cells12141874 · Cited by 50
Metadata
- Authors
- Sugimoto, M., & Abe, K.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-07-27
- Volume
- 3
- Issue
- 7
- Pages
- e116
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2020957347
- Cited by
- 214
- References
- 1
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sugimoto, M., & Abe, K. (2007). X Chromosome Reactivation Initiates in Nascent Primordial Germ Cells in Mice. PLoS Genetics. https://doi.org/10.1371/journal.pgen.0030116
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
