The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells
Open accessAbstract
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are largely unknown. We have carried out whole-genome bisulfite sequencing (BS-Seq) and RNA-Seq across key stages from E6.5 epiblast to E16.5 PGCs. Global loss of methylation takes place during PGC expansion and migration with evidence for passive demethylation, but sequences that carry long-term epigenetic memory (imprints, CpG islands on the X chromosome, germline-specific genes) only become demethylated upon entry of PGCs into the gonads. The transcriptional profile of PGCs is tightly controlled despite global hypomethylation, with transient expression of the pluripotency network, suggesting that reprogramming and pluripotency are inextricably linked. Our results provide a framework for the understanding of the epigenetic ground state of pluripotency in the germline.
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Global erasure of DNA methylation in primordial germ cells does not cause widespread transcriptional activation.
“For example, global erasure of DNA methylation in primordial germ cells (PGCs) does not lead to widespread transcriptional activation (16, 17)”
From Dynamic DNA methylation: In the right place at the right time (2018) · cites this paper as [16]
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BackgroundMethodInfluentialPotential functional roles of DNA demethylation intermediates
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- Authors
- Seisenberger, S., Andrews, S., Krueger, F., Arand, J., Walter, J., Santos, F., Popp, C., Thienpont, B., Dean, W., & Reik, W.
- Affiliations
- Babraham Institute (GB)
- Saarland University (DE)
- Corresponding author
- Reik, Wolf
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 48
- Issue
- 6
- Pages
- 849-862
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3533687
- OpenAlex
- W2071365780
- Cited by
- 973
- References
- 66
- Citations by year
- 2026: 47 · 2025: 55 · 2024: 46 · 2023: 57 · 2022: 77 · 2021: 63 · 2020: 62 · 2019: 93 · 2018: 83 · 2017: 82 · 2016: 80 · 2015: 91 · 2014: 71 · 2013: 63 · 2012: 2
- FWCI
- 29.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (095645)
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- DNA methylation reprogramming, primordial germ cells, epigenetic reprogramming, passive demethylation, germline, pluripotency, epiblast, CpG islands, transcriptional regulation, mouse embryo development
- MeSH terms
- Animals, Female, Germ Cells, Germ Layers, Male, Mice, Inbred C57BL, Transcription, Genetic, X Chromosome, Genome, Sequence Analysis, DNA, Genomic Imprinting, CpG Islands, DNA Methylation, Mice, Transcriptome
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