The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Adaptations to Climate in Candidate Genes for Common Metabolic Disorders
Open accessAbstract
Evolutionary pressures due to variation in climate play an important role in shaping phenotypic variation among and within species and have been shown to influence variation in phenotypes such as body shape and size among humans. Genes involved in energy metabolism are likely to be central to heat and cold tolerance. To test the hypothesis that climate shaped variation in metabolism genes in humans, we used a bioinformatics approach based on network theory to select 82 candidate genes for common metabolic disorders. We genotyped 873 tag SNPs in these genes in 54 worldwide populations (including the 52 in the Human Genome Diversity Project panel) and found correlations with climate variables using rank correlation analysis and a newly developed method termed Bayesian geographic analysis. In addition, we genotyped 210 carefully matched control SNPs to provide an empirical null distribution for spatial patterns of allele frequency due to population history alone. For nearly all climate variables, we found an excess of genic SNPs in the tail of the distributions of the test statistics compared to the control SNPs, implying that metabolic genes as a group show signals of spatially varying selection. Among our strongest signals were several SNPs (e.g., LEPR R109K, FABP2 A54T) that had previously been associated with phenotypes directly related to cold tolerance. Since variation in climate may be correlated with other aspects of environmental variation, it is possible that some of the signals that we detected reflect selective pressures other than climate. Nevertheless, our results are consistent with the idea that climate has been an important selective pressure acting on candidate genes for common metabolic disorders.
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Cites
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Cited by
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“In the future, therefore, we expect to see more success at identifying phenotypes or pathways that are enriched for selection signals [4,18,34,72,73], which will also bolster the support for the action of selection in general.”
Self-citationSequencing pools of individuals — mining genome-wide polymorphism data without big funding
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Self-citationUsing Environmental Correlations to Identify Loci Underlying Local Adaptation
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Self-citationDetecting Natural Selection in Genomic Data
Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133526 · Cited by 694
Metadata
- Authors
- Hancock, A. M., Witonsky, D. B., Gordon, A. S., Eshel, G., Pritchard, J. K., Coop, G., & Di Rienzo, A.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-02-15
- Volume
- 4
- Issue
- 2
- Pages
- e32
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W1992146473
- Cited by
- 272
- References
- 99
- FWCI
- 14.24
- Type
- journal article
- Language
- en
- Open access
- gold
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