The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis
Open accessAbstract
Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD) and periodontitis. Both diseases are associated with similar risk factors and are characterized by a chronic inflammatory process. In a candidate-gene association study, we identify an association of a genetic susceptibility locus shared by both diseases. We confirm the known association of two neighboring linkage disequilibrium regions on human chromosome 9p21.3 with CHD and show the additional strong association of these loci with the risk of aggressive periodontitis. For the lead SNP of the main associated linkage disequilibrium region, rs1333048, the odds ratio of the autosomal-recessive mode of inheritance is 1.99 (95% confidence interval 1.33-2.94; P = 6.9 x 10(-4)) for generalized aggressive periodontitis, and 1.72 (1.06-2.76; P = 2.6 x 10(-2)) for localized aggressive periodontitis. The two associated linkage disequilibrium regions map to the sequence of the large antisense noncoding RNA ANRIL, which partly overlaps regulatory and coding sequences of CDKN2A/CDKN2B. A closely located diabetes-associated variant was independent of the CHD and periodontitis risk haplotypes. Our study demonstrates that CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases.
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Inflammation and Atherosclerosis
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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
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Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
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Genomewide Association Analysis of Coronary Artery Disease
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A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
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Cited by
Risk factors for periodontal disease
Genco, R. J., & Borgnakke, W. S. (2013) · Periodontology 2000 · doi:10.1111/j.1600-0757.2012.00457.x · Cited by 1,232
Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases
Schenkein, H. A., & Loos, B. G. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12060 · Cited by 454
Self-citationKebschull, M., Demmer, R. T., & Papapanou, P. N. (2010) · Journal of Dental Research · doi:10.1177/0022034510375281 · Cited by 429
Genetics of Coronary Artery Disease
McPherson, R., & Tybjaerg-Hansen, A. (2016) · Circulation Research · doi:10.1161/circresaha.115.306566 · Cited by 371
Jepsen, K., & Jepsen, S. (2016) · Periodontology 2000 · doi:10.1111/prd.12121 · Cited by 306
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Metadata
- Authors
- Schaefer, A. S., Richter, G. M., Groessner-Schreiber, B., Noack, B., Nothnagel, M., Mokhtari, N.-E. E., Loos, B. G., Jepsen, S., & Schreiber, S.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-02-13
- Volume
- 5
- Issue
- 2
- Pages
- e1000378
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2168454329
- Cited by
- 236
- References
- 13
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- gold
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- Schaefer, A. S., Richter, G. M., Groessner-Schreiber, B., Noack, B., Nothnagel, M., Mokhtari, N.-E. E., Loos, B. G., Jepsen, S., & Schreiber, S. (2009). Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1000378
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