The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes
Open accessAbstract
The natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest. In humans, five different numts cause genetic disease and a dozen human loci are polymorphic for the presence of numts, underscoring the rapid rate at which mitochondrial sequences reach the nucleus over evolutionary time. In the laboratory and in nature, numts enter the nuclear DNA via non-homolgous end joining (NHEJ) at double-strand breaks (DSBs). The frequency of numt insertions among 85 sequenced eukaryotic genomes reveal that numt content is strongly correlated with genome size, suggesting that the numt insertion rate might be limited by DSB frequency. Polymorphic numts in humans link maternally inherited mitochondrial genotypes to nuclear DNA haplotypes during the past, offering new opportunities to associate nuclear markers with mitochondrial markers back in time.
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Cites
Rapid evolution of animal mitochondrial DNA
Brown, W. M., George, M., & Wilson, A. C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.4.1967 · Cited by 3,439
Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
Timmis, J. N., Ayliffe, M. A., Huang, C. Y., & Martin, W. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1271 · Cited by 1,568
Self-citationMitochondrial DNA sequences of primates: tempo and mode of evolution
Brown, W. M., Prager, E. M., Wang, A., & Wilson, A. C. (1982) · Journal of Molecular Evolution · doi:10.1007/bf01734101 · Cited by 1,554
Mitochondrial pseudogenes: evolution's misplaced witnesses
Bensasson, D. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(01)02151-6 · Cited by 1,142
Song, H., Buhay, J. E., Whiting, M. F., & Crandall, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803076105 · Cited by 1,034
Nuclear integrations: challenges for mitochondrial DNA markers
Zhang, D.-X., & Hewitt, G. M. (1996) · Trends in Ecology & Evolution · doi:10.1016/0169-5347(96)10031-8 · Cited by 931
Gould, S. B., Waller, R. F., & McFadden, G. I. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092915 · Cited by 634
Transposable elements and the evolution of genome size in eukaryotes
Kidwell, M. G. (2002) · Genetica · doi:10.1023/a:1016072014259 · Cited by 634
Lopez, J. V., Yuhki, N., Masuda, R., Modi, W., & O'Brien, S. J. (1994) · Journal of Molecular Evolution · doi:10.1007/bf00163806 · Cited by 615
Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation
Tovar, J., León-Avila, G., Sánchez, L. B., Sutak, R., Tachezy, J., van der Giezen, M., Hernández, M., Müller, M., & Lucocq, J. M. (2003) · Nature · doi:10.1038/nature01945 · Cited by 608
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Biochemistry and Evolution of Anaerobic Energy Metabolism in Eukaryotes
Müller, M., Mentel, M., van Hellemond, J. J., Henze, K., Woehle, C., Gould, S. B., Yu, R.-Y., van der Giezen, M., Tielens, A. G. M., & Martin, W. F. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05024-11 · Cited by 838
Self-citationHuman mitochondrial DNA: roles of inherited and somatic mutations
Schon, E. A., DiMauro, S., & Hirano, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3275 · Cited by 757
Origins and Recombination of the Bacterial-Sized Multichromosomal Mitochondrial Genome of Cucumber
Alverson, A. J., Rice, D. W., Dickinson, S., Barry, K., & Palmer, J. D. (2011) · The Plant Cell · doi:10.1105/tpc.111.087189 · Cited by 347
Mitochondrial DNA variation and cancer
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Metadata
- Authors
- Hazkani-Covo, E., Zeller, R. M., & Martin, W.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-02-12
- Volume
- 6
- Issue
- 2
- Pages
- e1000834
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2052850516
- Cited by
- 629
- References
- 87
- FWCI
- 42.93
- Type
- journal article
- Language
- en
- Open access
- gold
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